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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DUSP4

Summary for DUSP4

Gene information	Gene symbol	DUSP4
	Ensembl ID	ENSG00000120875
	Entrez ID	1846
	Gene name	dual specificity phosphatase 4
	Synonyms	HVH2\|MKP-2\|TYP
	Gene type	protein_coding
	UniProtAcc	Q13115

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Dataset with differentially expressed gene: DUSP4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.815613	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.431871	3.08e-44
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.27796	3.16e-04
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.769444	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.615315	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	0.707447	3.43e-04
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.671479	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	-0.282067	1.25e-27
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.416256	1.31e-08
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-1.3961	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-1.51467	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	1.24534	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.957783	1.52e-37
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.626345	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.706222	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.395855	2.14e-23
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.644519	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.537861	1.32e-34
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.555465	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.890435	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.517284	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.79416	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.569708	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.763748	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.550114	0.00e+00

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Expression of DUSP4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DUSP4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DUSP4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DUSP4	hsa-miR-4728-5p	98.5567	NM_057158
DUSP4	hsa-miR-6785-5p	98.4676	NM_057158
DUSP4	hsa-miR-149-3p	96.936	NM_057158
DUSP4	hsa-miR-6883-5p	96.936	NM_057158
DUSP4	hsa-miR-6876-3p	94.4658	NM_057158
DUSP4	hsa-miR-626	93.6216	NM_057158
DUSP4	hsa-miR-491-3p	93.2611	NM_057158
DUSP4	hsa-miR-4801	90.8124	NM_057158
DUSP4	hsa-miR-6857-3p	90.8088	NM_001394
DUSP4	hsa-miR-137-3p	89.2505	NM_001394
DUSP4	hsa-miR-4668-5p	88.5902	NM_001394
DUSP4	hsa-miR-498-5p	88.282	NM_001394
DUSP4	hsa-miR-4731-3p	88.161	NM_057158
DUSP4	hsa-miR-6830-5p	88.0086	NM_057158
DUSP4	hsa-miR-1249-5p	87.9367	NM_001394
DUSP4	hsa-miR-3663-3p	86.7024	NM_001394
DUSP4	hsa-miR-4533	85.3836	NM_001394
DUSP4	hsa-miR-6797-5p	84.8541	NM_001394
DUSP4	hsa-miR-3668	84.6207	NM_001394
DUSP4	hsa-miR-3942-5p	84.4396	NM_001394
DUSP4	hsa-miR-4703-5p	84.4396	NM_001394
DUSP4	hsa-miR-4714-5p	82.4973	NM_057158
DUSP4	hsa-miR-3913-3p	81.571	NM_057158
DUSP4	hsa-miR-8065	81.1361	NM_057158
DUSP4	hsa-miR-6818-3p	80.1112	NM_057158

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Motifs and transcription factors (TFs) regulating DUSP4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DUSP4	taipale__POU6F2_DBD_WTAATKAGCTMATTAW	POU6F2 (directAnnotation).
DUSP4	transfac_pro__M06353	ZNF782 (directAnnotation).
DUSP4	transfac_pro__M02015	FOXA3 (directAnnotation).
DUSP4	transfac_pro__M05794	ZNF621 (directAnnotation).
DUSP4	transfac_pro__M06834	PEG3 (directAnnotation).
DUSP4	hocomoco__FOXP3_HUMAN.H11MO.0.D	FOXP3 (directAnnotation).
DUSP4	transfac_pro__M05347	NR2C1 (directAnnotation).
DUSP4	transfac_pro__M00742	FOXJ1 (directAnnotation).
DUSP4	metacluster_179.4	MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2A; MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2C; MEF2C; MEF2C; MEF2C; MEF2C; MEF2C; MEF2C; MEF2C; MEF2D; MEF2D; MEF2D; MEF2D; MEF2D; MEF2D (directAnnotation). MEF2A; MEF2A; MEF2C; MEF2D; MEF2D; MYEF2 (inferredBy_Orthology).
DUSP4	metacluster_4.3	SMAD1; SOX10; SOX15; SOX18; SOX2; SOX2; SOX2; SOX3; SOX3; SOX4; SOX4; SOX4; SOX4; SOX6; SOX9; SOX9 (directAnnotation). NANOG; NANOGP8; SOX10; SOX11; SOX11; SOX17; SOX4; SOX6; SOX6; SOX9 (inferredBy_Orthology).
DUSP4	taipale_tf_pairs__CUX1_TBX21_TMACACCYAATA_CAP_repr	CUX1; TBX21 (directAnnotation).
DUSP4	tfdimers__MD00318	HNF4A; HNF4G; NR2F1; NR2F2; PAX4 (directAnnotation).
DUSP4	tfdimers__MD00411	ELF5; YY1 (directAnnotation).
DUSP4	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
DUSP4	transfac_pro__M04886	ETS1 (directAnnotation).
DUSP4	transfac_pro__M05682	ZNF25 (directAnnotation).
DUSP4	transfac_public__M00209	NFYA; NFYB; NFYC (directAnnotation).
DUSP4	transfac_pro__M05427	ZNF516 (directAnnotation).
DUSP4	metacluster_79.16	PRDM15; PRDM15 (inferredBy_Orthology).
DUSP4	kznf__ZSCAN29_TF_Evolution_PBM	ZSCAN29 (directAnnotation).
DUSP4	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
DUSP4	transfac_pro__M05731	ZNF660 (directAnnotation).
DUSP4	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
DUSP4	transfac_pro__M01886	NFATC3 (directAnnotation).
DUSP4	transfac_pro__M01861	ATF1 (directAnnotation).
DUSP4	transfac_pro__M07448	ZBED1 (directAnnotation).
DUSP4	metacluster_111.5	E4F1; E4F1 (directAnnotation).
DUSP4	transfac_pro__M06776	ZNF214 (directAnnotation).
DUSP4	kznf__CTCF_Transfac.7_Transfac	CTCF (directAnnotation).
DUSP4	tfdimers__MD00071	CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; SOX10 (directAnnotation).
DUSP4	tfdimers__MD00465	CRX; IKZF1 (directAnnotation).
DUSP4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
DUSP4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DUSP4	cisbp__M00249	WT1 (directAnnotation).
DUSP4	cisbp__M00809	PRDM11 (inferredBy_Orthology).
DUSP4	hdpi__NRL	NRL (directAnnotation).
DUSP4	transfac_pro__M02898	SMAD3 (directAnnotation).
DUSP4	transfac_pro__M01122	ZNF219 (directAnnotation).
DUSP4	dbtfbs__HIC1_HEK293_ENCSR803GYT_merged_N1	HIC1 (directAnnotation).
DUSP4	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
DUSP4	kznf__ZBTB12_Schmitges2016_RCADE	ZBTB12 (directAnnotation).
DUSP4	transfac_pro__M06383	ZNF629 (inferredBy_Orthology).
DUSP4	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
DUSP4	transfac_public__M00040	ATF2 (directAnnotation).
DUSP4	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
DUSP4	transfac_pro__M07436	WT1 (directAnnotation).
DUSP4	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
DUSP4	transfac_pro__M07329	SP7 (directAnnotation).
DUSP4	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
DUSP4	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."