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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CTNNB1

Summary for CTNNB1

Gene information	Gene symbol	CTNNB1
	Ensembl ID	ENSG00000168036
	Entrez ID	1499
	Gene name	catenin beta 1
	Synonyms	armadillo\|beta-catenin\|CTNNB
	Gene type	protein_coding
	UniProtAcc	P35222

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Dataset with differentially expressed gene: CTNNB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.313128	3.58e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.507146	2.85e-30
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.72534	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.479031	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.323448	6.93e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.484839	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.427104	5.50e-37
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.502429	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.522709	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.844048	0.00e+00

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Expression of CTNNB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CTNNB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CTNNB1	Regulation by the Disease Microenvironment
CTNNB1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CTNNB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CTNNB1	hsa-miR-3613-3p	99.4048	NM_001904
CTNNB1	hsa-miR-3162-3p	98.2776	NM_001904
CTNNB1	hsa-miR-548g-5p	97.8671	NM_001904
CTNNB1	hsa-miR-548x-5p	97.8671	NM_001904
CTNNB1	hsa-miR-548aj-5p	97.8671	NM_001904
CTNNB1	hsa-miR-548f-5p	97.8671	NM_001904
CTNNB1	hsa-miR-183-3p	97.7022	NM_001904
CTNNB1	hsa-miR-3688-5p	97.3434	NM_001904
CTNNB1	hsa-miR-4496	97.0626	NM_001904
CTNNB1	hsa-miR-4999-5p	97.0069	NM_001904
CTNNB1	hsa-miR-885-5p	96.9401	NM_001904
CTNNB1	hsa-miR-561-3p	95.5993	NM_001904
CTNNB1	hsa-miR-1468-3p	94.4608	NM_001904
CTNNB1	hsa-miR-548aw	94.4351	NM_001904
CTNNB1	hsa-miR-548n	92.6437	NM_001904
CTNNB1	hsa-miR-4708-3p	92.2256	NM_001904
CTNNB1	hsa-miR-4776-5p	92.1847	NM_001904
CTNNB1	hsa-miR-4733-5p	92.0995	NM_001098210
CTNNB1	hsa-miR-6792-5p	92.021	NM_001904
CTNNB1	hsa-miR-3120-3p	91.9731	NM_001904
CTNNB1	hsa-let-7f-1-3p	91.5214	NM_001098210
CTNNB1	hsa-let-7a-3p	91.5214	NM_001098210
CTNNB1	hsa-miR-98-3p	91.5214	NM_001098210
CTNNB1	hsa-let-7b-3p	91.5214	NM_001098210
CTNNB1	hsa-miR-6512-5p	90.856	NM_001904
CTNNB1	hsa-miR-6513-5p	90.3899	NM_001098210
CTNNB1	hsa-miR-4503	90.346	NM_001098210
CTNNB1	hsa-miR-892c-5p	90.2004	NM_001098210
CTNNB1	hsa-miR-4418	89.6341	NM_001904
CTNNB1	hsa-miR-6807-3p	89.6341	NM_001904
CTNNB1	hsa-miR-509-5p	89.5753	NM_001904
CTNNB1	hsa-miR-217-5p	89.5753	NM_001904
CTNNB1	hsa-miR-509-3-5p	89.5753	NM_001904
CTNNB1	hsa-miR-891a-3p	88.5479	NM_001904
CTNNB1	hsa-miR-589-3p	88.2951	NM_001904
CTNNB1	hsa-miR-548t-5p	88.057	NM_001904
CTNNB1	hsa-miR-548az-5p	88.057	NM_001904
CTNNB1	hsa-miR-6715b-5p	87.497	NM_001904
CTNNB1	hsa-miR-4269	87.497	NM_001904
CTNNB1	hsa-miR-3619-3p	87.3016	NM_001904
CTNNB1	hsa-miR-642b-5p	86.6703	NM_001904
CTNNB1	hsa-miR-3119	86.343	NM_001904
CTNNB1	hsa-miR-6816-3p	86.0022	NM_001098209
CTNNB1	hsa-miR-10399-5p	85.0745	NM_001904
CTNNB1	hsa-miR-4643	84.852	NM_001904
CTNNB1	hsa-miR-3529-3p	84.8004	NM_001098210
CTNNB1	hsa-miR-545-3p	84.6479	NM_001904
CTNNB1	hsa-miR-495-5p	84.6325	NM_001904
CTNNB1	hsa-miR-214-3p	82.855	NM_001904
CTNNB1	hsa-miR-761	82.855	NM_001904

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Motifs and transcription factors (TFs) regulating CTNNB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CTNNB1	transfac_pro__M07397	ZNF148 (directAnnotation).
CTNNB1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
CTNNB1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CTNNB1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CTNNB1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CTNNB1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CTNNB1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CTNNB1	cisbp__M02645	ETS1 (directAnnotation).
CTNNB1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
CTNNB1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CTNNB1	cisbp__M08198	ELF1 (directAnnotation).
CTNNB1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CTNNB1	transfac_pro__M04748	GABPA (directAnnotation).
CTNNB1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CTNNB1	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
CTNNB1	jaspar__MA1708.1	ETV7 (directAnnotation).
CTNNB1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
CTNNB1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
CTNNB1	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
CTNNB1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CTNNB1	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
CTNNB1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
CTNNB1	taipale_tf_pairs__MYBL1_EOMES_NNSYGNCNAACNNNNNNCACRCNN_CAP_repr	EOMES; MYBL1 (directAnnotation).
CTNNB1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
CTNNB1	transfac_pro__M06135	ZNF28 (directAnnotation).
CTNNB1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CTNNB1	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
CTNNB1	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
CTNNB1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_1	ELK1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CTNNB1	"Urea"	DB03904	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."