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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC50

Summary for CCDC50

Gene information	Gene symbol	CCDC50
	Ensembl ID	ENSG00000152492
	Entrez ID	152137
	Gene name	coiled-coil domain containing 50
	Synonyms	C3orf6\|DFNA44\|Ymer
	Gene type	protein_coding
	UniProtAcc	Q8IVM0

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Dataset with differentially expressed gene: CCDC50

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.515877	2.77e-36
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.305921	3.69e-37
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.42259	1.87e-21
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.383491	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-1.56525	7.63e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.482662	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	pDCs	-0.954526	4.49e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	1.05592	3.94e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.459938	2.25e-16

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Expression of CCDC50 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC50

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC50

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC50	hsa-miR-539-5p	97.4462	NM_174908
CCDC50	hsa-miR-5011-5p	95.6375	NM_174908
CCDC50	hsa-miR-3646	94.4092	NM_174908
CCDC50	hsa-miR-335-3p	94.1737	NM_174908
CCDC50	hsa-miR-190a-3p	93.812	NM_174908
CCDC50	hsa-miR-218-5p	93.6644	NM_174908
CCDC50	hsa-miR-4668-5p	93.3935	NM_174908
CCDC50	hsa-miR-153-3p	92.5499	NM_174908
CCDC50	hsa-miR-216b-5p	92.529	NM_174908
CCDC50	hsa-miR-183-3p	92.4076	NM_174908
CCDC50	hsa-miR-3714	91.9136	NM_174908
CCDC50	hsa-miR-12123	91.7835	NM_174908
CCDC50	hsa-miR-203a-3p	91.6468	NM_174908
CCDC50	hsa-miR-103a-3p	91.0474	NM_174908
CCDC50	hsa-miR-107	91.0474	NM_174908
CCDC50	hsa-miR-605-5p	89.7858	NM_174908
CCDC50	hsa-miR-186-5p	89.4261	NM_174908
CCDC50	hsa-miR-6809-3p	89.2639	NM_174908
CCDC50	hsa-miR-8057	88.663	NM_174908
CCDC50	hsa-miR-5692a	87.2393	NM_174908
CCDC50	hsa-miR-767-5p	87.2007	NM_174908
CCDC50	hsa-miR-9-5p	86.9985	NM_174908
CCDC50	hsa-miR-559	86.9149	NM_174908
CCDC50	hsa-miR-3910	86.203	NM_174908
CCDC50	hsa-miR-548ad-5p	86.0446	NM_174908
CCDC50	hsa-miR-548h-5p	86.0446	NM_174908
CCDC50	hsa-miR-548b-5p	86.0446	NM_174908
CCDC50	hsa-miR-548c-5p	86.0446	NM_174908
CCDC50	hsa-miR-548aq-5p	86.0446	NM_174908
CCDC50	hsa-miR-548ae-5p	86.0446	NM_174908
CCDC50	hsa-miR-548ap-5p	86.0446	NM_174908
CCDC50	hsa-miR-548a-5p	86.0446	NM_174908
CCDC50	hsa-miR-548i	86.0446	NM_174908
CCDC50	hsa-miR-548ar-5p	86.0446	NM_174908
CCDC50	hsa-miR-548bb-5p	86.0446	NM_174908
CCDC50	hsa-miR-548as-5p	86.0446	NM_174908
CCDC50	hsa-miR-548j-5p	86.0446	NM_174908
CCDC50	hsa-miR-548d-5p	86.0446	NM_174908
CCDC50	hsa-miR-548o-5p	86.0446	NM_174908
CCDC50	hsa-miR-548ay-5p	86.0446	NM_174908
CCDC50	hsa-miR-548am-5p	86.0446	NM_174908
CCDC50	hsa-miR-548ab	86.0446	NM_174908
CCDC50	hsa-miR-548au-5p	86.0446	NM_174908
CCDC50	hsa-miR-548w	86.0446	NM_174908
CCDC50	hsa-miR-548y	86.0446	NM_174908
CCDC50	hsa-miR-548ak	86.0446	NM_174908
CCDC50	hsa-miR-520b-5p	85.5089	NM_174908
CCDC50	hsa-miR-519a-2-5p	85.5089	NM_174908
CCDC50	hsa-miR-548c-3p	85.4474	NM_174908
CCDC50	hsa-miR-153-5p	85.3436	NM_174908

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Motifs and transcription factors (TFs) regulating CCDC50

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC50	transfac_public__M00114	CREB1 (directAnnotation).
CCDC50	transfac_pro__M09767	ASCL1 (directAnnotation).
CCDC50	transfac_pro__M06749	ZNF222 (directAnnotation).
CCDC50	transfac_pro__M06524	ZNF721 (directAnnotation).
CCDC50	hdpi__NRL	NRL (directAnnotation).
CCDC50	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CCDC50	hdpi__FEZF2	FEZF2 (directAnnotation).
CCDC50	transfac_pro__M07310	SP5 (directAnnotation).
CCDC50	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CCDC50	metacluster_155.11	SPZ1 (directAnnotation).
CCDC50	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CCDC50	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
CCDC50	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
CCDC50	transfac_pro__M02089	E2F3 (directAnnotation).
CCDC50	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CCDC50	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CCDC50	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CCDC50	metacluster_19.9	AHR; AHR; SREBF1; SREBF1; SREBF2; SREBF2 (directAnnotation). SREBF1 (inferredBy_Orthology).
CCDC50	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).
CCDC50	cisbp__M00809	PRDM11 (inferredBy_Orthology).
CCDC50	transfac_pro__M02898	SMAD3 (directAnnotation).
CCDC50	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CCDC50	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CCDC50	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
CCDC50	transfac_pro__M01122	ZNF219 (directAnnotation).
CCDC50	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CCDC50	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CCDC50	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CCDC50	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CCDC50	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CCDC50	transfac_pro__M07329	SP7 (directAnnotation).
CCDC50	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
CCDC50	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CCDC50	cisbp__M07938	E2F1 (directAnnotation).
CCDC50	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CCDC50	transfac_pro__M07436	WT1 (directAnnotation).
CCDC50	metacluster_3.14	WT1; WT1 (directAnnotation).
CCDC50	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CCDC50	transfac_pro__M01837	KLF11 (directAnnotation).
CCDC50	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CCDC50	transfac_pro__M04817	ZBTB33 (directAnnotation).
CCDC50	swissregulon__hs__KLF6	KLF6 (directAnnotation).
CCDC50	transfac_pro__M00716	ZBTB14 (directAnnotation).
CCDC50	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CCDC50	metacluster_163.2	ZNF682 (directAnnotation).
CCDC50	transfac_pro__M04916	TAF1 (directAnnotation).
CCDC50	transfac_pro__M00938	E2F1 (directAnnotation).
CCDC50	transfac_pro__M02090	E2F4 (directAnnotation).
CCDC50	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CCDC50	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."