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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANP32A

Summary for ANP32A

Gene information	Gene symbol	ANP32A
	Ensembl ID	ENSG00000140350
	Entrez ID	8125
	Gene name	acidic nuclear phosphoprotein 32 family member A
	Synonyms	C15orf1\|I1PP2A\|LANP\|MAPM\|mapmodulin\|PHAPI\|PP32
	Gene type	protein_coding
	UniProtAcc	P39687

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Dataset with differentially expressed gene: ANP32A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.340451	2.35e-21
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.600149	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	NK cells	0.331515	4.16e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.322387	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.266209	7.61e-15
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.755129	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.416881	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.846666	3.43e-04
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.370708	3.12e-19
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.393848	3.47e-14
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.380421	1.16e-16
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.392969	3.69e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.419823	0.00e+00

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Expression of ANP32A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANP32A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANP32A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANP32A	hsa-miR-939-3p	93.2933	NM_006305
ANP32A	hsa-miR-5683	92.85	NM_006305
ANP32A	hsa-miR-6783-5p	89.183	NM_006305
ANP32A	hsa-miR-1185-1-3p	88.9776	NM_006305
ANP32A	hsa-miR-1185-2-3p	88.9776	NM_006305
ANP32A	hsa-let-7f-2-3p	88.9776	NM_006305
ANP32A	hsa-miR-149-5p	87.8155	NM_006305
ANP32A	hsa-miR-6798-5p	87.519	NM_006305
ANP32A	hsa-miR-2115-3p	87.519	NM_006305
ANP32A	hsa-miR-4659a-3p	83.2628	NM_006305
ANP32A	hsa-miR-4659b-3p	83.2628	NM_006305
ANP32A	hsa-miR-568	81.7279	NM_006305
ANP32A	hsa-miR-548au-3p	81.0902	NM_006305
ANP32A	hsa-miR-449a	81.0902	NM_006305
ANP32A	hsa-miR-34a-5p	81.0902	NM_006305
ANP32A	hsa-miR-211-3p	80.802	NM_006305
ANP32A	hsa-miR-3136-3p	80.2324	NM_006305
ANP32A	hsa-miR-7155-3p	80.2324	NM_006305
ANP32A	hsa-miR-589-3p	80.0901	NM_006305

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Motifs and transcription factors (TFs) regulating ANP32A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANP32A	transfac_pro__M04848	TAF1 (directAnnotation).
ANP32A	jaspar__MA0502.2	NFYB (directAnnotation).
ANP32A	transfac_pro__M02089	E2F3 (directAnnotation).
ANP32A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ANP32A	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ANP32A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ANP32A	transfac_pro__M00430	E2F1 (directAnnotation).
ANP32A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ANP32A	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ANP32A	transfac_pro__M07329	SP7 (directAnnotation).
ANP32A	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
ANP32A	cisbp__M07938	E2F1 (directAnnotation).
ANP32A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ANP32A	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ANP32A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ANP32A	transfac_pro__M07436	WT1 (directAnnotation).
ANP32A	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ANP32A	transfac_pro__M01837	KLF11 (directAnnotation).
ANP32A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ANP32A	transfac_pro__M07310	SP5 (directAnnotation).
ANP32A	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ANP32A	transfac_pro__M04817	ZBTB33 (directAnnotation).
ANP32A	swissregulon__hs__KLF6	KLF6 (directAnnotation).
ANP32A	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
ANP32A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ANP32A	transfac_pro__M01175	ZBTB7B (directAnnotation).
ANP32A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ANP32A	transfac_pro__M07297	MAZ (directAnnotation).
ANP32A	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ANP32A	metacluster_163.2	ZNF682 (directAnnotation).
ANP32A	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
ANP32A	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
ANP32A	transfac_pro__M00938	E2F1 (directAnnotation).
ANP32A	transfac_pro__M02090	E2F4 (directAnnotation).
ANP32A	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."