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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: AHR

Summary for AHR

Gene information	Gene symbol	AHR
	Ensembl ID	ENSG00000106546
	Entrez ID	196
	Gene name	aryl hydrocarbon receptor
	Synonyms	bHLHe76
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AHR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.447135	5.86e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.284939	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.310621	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.269743	7.37e-10
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.5869	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.763127	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.518284	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.03427	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.456232	0.00e+00

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Expression of AHR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AHR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AHR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AHR	hsa-miR-380-3p	99.8895	NM_001621
AHR	hsa-miR-548e-5p	99.3557	NM_001621
AHR	hsa-miR-5692a	98.9679	NM_001621
AHR	hsa-miR-4795-3p	98.5081	NM_001621
AHR	hsa-miR-374b-5p	98.4524	NM_001621
AHR	hsa-miR-411-3p	98.3261	NM_001621
AHR	hsa-miR-379-3p	98.3261	NM_001621
AHR	hsa-miR-4495	98.2923	NM_001621
AHR	hsa-miR-374a-5p	98.2347	NM_001621
AHR	hsa-miR-4666a-3p	97.8176	NM_001621
AHR	hsa-miR-5002-5p	97.2716	NM_001621
AHR	hsa-miR-186-5p	97.0465	NM_001621
AHR	hsa-miR-607	96.5077	NM_001621
AHR	hsa-miR-1305	95.9604	NM_001621
AHR	hsa-miR-12123	95.5733	NM_001621
AHR	hsa-miR-4316	95.2321	NM_001621
AHR	hsa-miR-8087	94.896	NM_001621
AHR	hsa-miR-3163	94.8169	NM_001621
AHR	hsa-miR-4775	94.7099	NM_001621
AHR	hsa-miR-4282	94.6747	NM_001621
AHR	hsa-miR-1827	94.4925	NM_001621
AHR	hsa-miR-142-5p	94.2969	NM_001621
AHR	hsa-miR-124-3p	93.9779	NM_001621
AHR	hsa-miR-506-3p	93.9779	NM_001621
AHR	hsa-let-7f-1-3p	93.4532	NM_001621
AHR	hsa-miR-98-3p	93.4532	NM_001621
AHR	hsa-let-7a-3p	93.4532	NM_001621
AHR	hsa-let-7b-3p	93.4532	NM_001621
AHR	hsa-miR-5590-3p	93.1381	NM_001621
AHR	hsa-miR-6505-5p	93.0638	NM_001621
AHR	hsa-miR-190a-3p	93.0255	NM_001621
AHR	hsa-miR-4328	92.8078	NM_001621
AHR	hsa-miR-381-3p	92.5024	NM_001621
AHR	hsa-miR-300	92.5024	NM_001621
AHR	hsa-miR-7-2-3p	92.2269	NM_001621
AHR	hsa-miR-7-1-3p	92.2269	NM_001621
AHR	hsa-miR-6831-5p	91.9423	NM_001621
AHR	hsa-miR-3927-3p	90.7596	NM_001621
AHR	hsa-miR-8066	90.2912	NM_001621
AHR	hsa-miR-577	90.2522	NM_001621
AHR	hsa-miR-126-5p	90.1936	NM_001621
AHR	hsa-miR-433-3p	89.9689	NM_001621
AHR	hsa-miR-4653-3p	89.743	NM_001621
AHR	hsa-miR-576-5p	89.7093	NM_001621
AHR	hsa-miR-3123	89.4489	NM_001621
AHR	hsa-miR-340-5p	88.9702	NM_001621
AHR	hsa-miR-3679-5p	88.8814	NM_001621
AHR	hsa-miR-302c-5p	88.8735	NM_001621
AHR	hsa-miR-6507-5p	88.7208	NM_001621
AHR	hsa-miR-4261	88.6686	NM_001621

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Motifs and transcription factors (TFs) regulating AHR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AHR	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
AHR	hdpi__TIMELESS	TIMELESS (directAnnotation).
AHR	transfac_pro__M04877	GTF3C2 (directAnnotation).
AHR	transfac_public__M00072	TFCP2 (directAnnotation).
AHR	tfdimers__MD00167	HIC1; MAFA (directAnnotation).
AHR	hdpi__HTATIP2	HTATIP2 (directAnnotation).
AHR	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
AHR	transfac_pro__M12634	ZBTB17 (directAnnotation).
AHR	tfdimers__MD00343	HIC1; TP53 (directAnnotation).
AHR	transfac_public__M00005	TFAP4 (directAnnotation).
AHR	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
AHR	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
AHR	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).
AHR	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
AHR	jaspar__MA0131.2	HINFP (directAnnotation).
AHR	metacluster_135.1	ZNF561 (directAnnotation).
AHR	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
AHR	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
AHR	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
AHR	jaspar__MA1650.1	ZBTB14 (directAnnotation).
AHR	transfac_pro__M02089	E2F3 (directAnnotation).
AHR	transfac_pro__M00322	MAX; MYC (directAnnotation).
AHR	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
AHR	transfac_public__M00114	CREB1 (directAnnotation).
AHR	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
AHR	taipale_tf_pairs__ERF_SREBF2_NNCACGTGACMGGAARNN_CAP_repr	ERF; SREBF2 (directAnnotation).
AHR	metacluster_175.5	IRX3; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP63; TP63; TP63; TP63; TP63; TP63; TP73; TP73; TP73; TP73; TP73; TP73 (directAnnotation). TP53; TP53; TP53; TP73 (inferredBy_Orthology).
AHR	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).
AHR	cisbp__M07938	E2F1 (directAnnotation).
AHR	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
AHR	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
AHR	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
AHR	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
AHR	cisbp__M04023	CREB1 (directAnnotation).
AHR	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
AHR	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
AHR	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
AHR	metacluster_111.5	E4F1; E4F1 (directAnnotation).
AHR	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
AHR	transfac_pro__M01864	ATF4 (directAnnotation).
AHR	transfac_pro__M08803	CREM (directAnnotation).
AHR	hdpi__RARA	RARA (directAnnotation).
AHR	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
AHR	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
AHR	hocomoco__FEV_HUMAN.H11MO.0.B	FEV (directAnnotation).
AHR	hdpi__HIP2	UBE2K (directAnnotation).
AHR	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
AHR	hdpi__PDLIM5	PDLIM5 (directAnnotation).
AHR	transfac_pro__M03846	SMAD5 (directAnnotation).
AHR	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
AHR	"1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine"	DB08624	small molecule
AHR	"Atorvastatin"	DB01076	small molecule
AHR	"beta-Naphthoflavone"	DB06732	small molecule
AHR	"Cantharidin"	DB12328	small molecule
AHR	"Carbendazim"	DB13009	small molecule
AHR	"Diosmin"	DB08995	small molecule
AHR	"Emodin"	DB07715	small molecule
AHR	"Epigallocatechin gallate"	DB12116	small molecule
AHR	"Flutamide"	DB00499	small molecule
AHR	"Ginseng"	DB01404	biotech
AHR	"Indigo"	DB16862	small molecule
AHR	"Indirubin"	DB12379	small molecule
AHR	"Indirubin-3'-monoxime"	DB02052	small molecule
AHR	"Kynurenic Acid"	DB11937	small molecule
AHR	"Leflunomide"	DB01097	small molecule
AHR	"Mexiletine"	DB00379	small molecule
AHR	"Nimodipine"	DB00393	small molecule
AHR	"Omeprazole"	DB00338	small molecule
AHR	"Quercetin"	DB04216	small molecule
AHR	"Resveratrol"	DB02709	small molecule
AHR	"Tapinarof"	DB06083	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."