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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AFF4

Summary for AFF4

Gene information	Gene symbol	AFF4
	Ensembl ID	ENSG00000072364
	Entrez ID	27125
	Gene name	ALF transcription elongation factor 4
	Synonyms	AF5Q31\|MCEF
	Gene type	protein_coding
	UniProtAcc	Q9UHB7

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Dataset with differentially expressed gene: AFF4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.272523	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.290452	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.267124	5.69e-06
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.277734	4.04e-06
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.929145	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.308238	1.28e-43
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.489158	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.376508	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.345875	2.78e-19
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.302417	4.66e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.283259	6.20e-42
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.399578	1.31e-25

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Expression of AFF4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AFF4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AFF4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AFF4	hsa-miR-5692a	99.9664	NM_014423
AFF4	hsa-miR-519e-5p	99.9244	NM_014423
AFF4	hsa-miR-515-5p	99.9244	NM_014423
AFF4	hsa-miR-128-3p	99.7864	NM_014423
AFF4	hsa-miR-216a-3p	99.7864	NM_014423
AFF4	hsa-miR-3681-3p	99.6833	NM_014423
AFF4	hsa-miR-27b-3p	99.6737	NM_014423
AFF4	hsa-miR-9985	99.6737	NM_014423
AFF4	hsa-miR-27a-3p	99.6737	NM_014423
AFF4	hsa-miR-5700	99.4946	NM_014423
AFF4	hsa-miR-519d-5p	99.3325	NM_014423
AFF4	hsa-miR-5011-5p	99.2501	NM_014423
AFF4	hsa-miR-203a-3p	98.8974	NM_014423
AFF4	hsa-miR-3148	98.8299	NM_014423
AFF4	hsa-miR-548c-3p	98.6608	NM_014423
AFF4	hsa-miR-3065-5p	98.5592	NM_014423
AFF4	hsa-miR-607	98.4352	NM_014423
AFF4	hsa-miR-642a-3p	98.4304	NM_014423
AFF4	hsa-miR-642b-3p	98.4304	NM_014423
AFF4	hsa-miR-3671	98.3971	NM_014423
AFF4	hsa-miR-3692-3p	98.3389	NM_014423
AFF4	hsa-miR-4328	97.5988	NM_014423
AFF4	hsa-miR-5695	97.0675	NM_014423
AFF4	hsa-miR-6762-3p	97.0654	NM_014423
AFF4	hsa-miR-410-3p	96.6708	NM_014423
AFF4	hsa-miR-6833-5p	96.5798	NM_014423
AFF4	hsa-miR-513a-3p	95.5749	NM_014423
AFF4	hsa-miR-513c-3p	95.5749	NM_014423
AFF4	hsa-miR-550b-3p	95.2509	NM_014423
AFF4	hsa-miR-548m	95.2209	NM_014423
AFF4	hsa-miR-1225-3p	94.7639	NM_014423
AFF4	hsa-miR-4797-5p	94.7064	NM_014423
AFF4	hsa-miR-3145-3p	94.6882	NM_014423
AFF4	hsa-miR-4272	94.593	NM_014423
AFF4	hsa-miR-95-5p	94.5341	NM_014423
AFF4	hsa-miR-4429	94.3171	NM_014423
AFF4	hsa-miR-320c	94.3171	NM_014423
AFF4	hsa-miR-320b	94.3171	NM_014423
AFF4	hsa-miR-320a-3p	94.3171	NM_014423
AFF4	hsa-miR-320d	94.3171	NM_014423
AFF4	hsa-miR-5590-3p	94.2648	NM_014423
AFF4	hsa-miR-3606-3p	94.0311	NM_014423
AFF4	hsa-let-7c-3p	93.7228	NM_014423
AFF4	hsa-miR-196a-1-3p	93.4664	NM_014423
AFF4	hsa-miR-142-5p	93.4619	NM_014423
AFF4	hsa-miR-421	93.3889	NM_014423
AFF4	hsa-miR-5004-3p	93.3474	NM_014423
AFF4	hsa-miR-4766-5p	93.1558	NM_014423
AFF4	hsa-miR-5197-3p	93.0396	NM_014423
AFF4	hsa-miR-4743-3p	92.8393	NM_014423

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Motifs and transcription factors (TFs) regulating AFF4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AFF4	transfac_pro__M07436	WT1 (directAnnotation).
AFF4	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
AFF4	metacluster_3.14	WT1; WT1 (directAnnotation).
AFF4	metacluster_19.9	AHR; AHR; SREBF1; SREBF1; SREBF2; SREBF2 (directAnnotation). SREBF1 (inferredBy_Orthology).
AFF4	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).
AFF4	cisbp__M00809	PRDM11 (inferredBy_Orthology).
AFF4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
AFF4	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
AFF4	transfac_public__M00114	CREB1 (directAnnotation).
AFF4	transfac_pro__M01122	ZNF219 (directAnnotation).
AFF4	dbtfbs__HIC1_HEK293_ENCSR803GYT_merged_N1	HIC1 (directAnnotation).
AFF4	kznf__EGR2_Barrera2016.1_PBM	EGR2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."