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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADD3

Summary for ADD3

Gene information	Gene symbol	ADD3
	Ensembl ID	ENSG00000148700
	Entrez ID	120
	Gene name	adducin 3
	Synonyms	ADDL
	Gene type	protein_coding
	UniProtAcc	Q9UEY8

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Dataset with differentially expressed gene: ADD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.2872	3.14e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.28432	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.353531	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.356919	2.28e-06
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.260655	2.84e-37
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.383322	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.813616	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.297458	1.03e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.258574	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.462462	0.00e+00

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Expression of ADD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADD3	hsa-miR-5195-3p	99.3925	NM_001121
ADD3	hsa-miR-374a-5p	99.298	NM_019903
ADD3	hsa-miR-145-5p	99.2619	NM_001121
ADD3	hsa-miR-374b-5p	98.695	NM_019903
ADD3	hsa-miR-5011-5p	98.3966	NM_019903
ADD3	hsa-miR-7844-5p	96.9994	NM_001121
ADD3	hsa-miR-4424	96.3994	NM_001121
ADD3	hsa-miR-9983-3p	96.2468	NM_019903
ADD3	hsa-miR-627-3p	95.9921	NM_001121
ADD3	hsa-miR-1208	95.7662	NM_019903
ADD3	hsa-miR-182-5p	95.7429	NM_001121
ADD3	hsa-miR-892c-3p	95.4691	NM_019903
ADD3	hsa-miR-4676-3p	95.4691	NM_019903
ADD3	hsa-miR-452-5p	95.4691	NM_019903
ADD3	hsa-miR-4470	95.3051	NM_019903
ADD3	hsa-miR-4282	95.0785	NM_001121
ADD3	hsa-miR-365b-3p	94.6743	NM_001121
ADD3	hsa-miR-365a-3p	94.6743	NM_001121
ADD3	hsa-miR-129-5p	94.5298	NM_019903
ADD3	hsa-miR-5681b	93.626	NM_019903
ADD3	hsa-miR-190a-3p	93.5889	NM_019903
ADD3	hsa-miR-302c-5p	93.5596	NM_019903
ADD3	hsa-miR-6088	92.9992	NM_001121
ADD3	hsa-miR-143-3p	92.9992	NM_001121
ADD3	hsa-miR-4770	92.9992	NM_001121
ADD3	hsa-miR-4729	92.7387	NM_001121
ADD3	hsa-miR-4735-3p	92.6766	NM_001121
ADD3	hsa-miR-18a-5p	92.6766	NM_001121
ADD3	hsa-miR-18b-5p	92.6766	NM_001121
ADD3	hsa-miR-548c-3p	92.3303	NM_019903
ADD3	hsa-miR-4536-5p	92.0639	NM_001121
ADD3	hsa-miR-3143	91.8069	NM_019903
ADD3	hsa-miR-3129-3p	90.9675	NM_019903
ADD3	hsa-miR-5583-5p	90.9675	NM_019903
ADD3	hsa-miR-455-5p	90.6035	NM_001121
ADD3	hsa-miR-5582-3p	90.3288	NM_001121
ADD3	hsa-miR-548at-5p	89.2213	NM_001121
ADD3	hsa-miR-513a-5p	89.2044	NM_001121
ADD3	hsa-miR-10395-3p	88.8948	NM_001121
ADD3	hsa-miR-3668	88.07	NM_001121
ADD3	hsa-miR-4422	87.6961	NM_019903
ADD3	hsa-miR-4712-5p	87.6366	NM_001121
ADD3	hsa-miR-770-5p	87.6366	NM_001121
ADD3	hsa-miR-516b-5p	87.4801	NM_019903
ADD3	hsa-miR-3529-3p	87.4158	NM_001121
ADD3	hsa-miR-491-3p	87.3302	NM_019903
ADD3	hsa-miR-330-3p	87.0702	NM_001121
ADD3	hsa-miR-3692-3p	86.9709	NM_001121
ADD3	hsa-miR-3129-5p	86.8117	NM_001121
ADD3	hsa-miR-6502-5p	86.6408	NM_001121

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Motifs and transcription factors (TFs) regulating ADD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADD3	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
ADD3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ADD3	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ADD3	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ADD3	jaspar__MA0748.2	YY2 (directAnnotation).
ADD3	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
ADD3	transfac_pro__M01175	ZBTB7B (directAnnotation).
ADD3	transfac_pro__M07297	MAZ (directAnnotation).
ADD3	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ADD3	metacluster_163.2	ZNF682 (directAnnotation).
ADD3	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
ADD3	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
ADD3	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ADD3	transfac_pro__M01303	SP1 (directAnnotation).
ADD3	transfac_pro__M06772	ZNF780B (directAnnotation).
ADD3	metacluster_0.5	ZNF264 (directAnnotation).
ADD3	transfac_pro__M05829	ZNF627 (directAnnotation).
ADD3	taipale_tf_pairs__ETV2_FOXI1_RSCGGAANNRYMAACAN_CAP	ETV2; FOXI1 (directAnnotation).
ADD3	metacluster_155.13	ZNF135 (directAnnotation).
ADD3	transfac_pro__M05596	ZNF143 (directAnnotation).
ADD3	metacluster_139.9	TFE3 (inferredBy_Orthology).
ADD3	tfdimers__MD00406	NEUROD1 (directAnnotation).
ADD3	transfac_pro__M04913	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."