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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ZBTB43

Summary for ZBTB43

Gene information	Gene symbol	ZBTB43
	Ensembl ID	ENSG00000169155
	Entrez ID	23099
	Gene name	zinc finger and BTB domain containing 43
	Synonyms	FLJ22470\|KIAA0414\|ZBTB22B\|ZNF-X\|ZNF297B
	Gene type	protein_coding
	UniProtAcc	O43298

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Dataset with differentially expressed gene: ZBTB43

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.423308	4.96e-23
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.279564	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.34824	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.737707	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.317764	9.19e-08
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.33036	1.51e-18

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Expression of ZBTB43 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZBTB43

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZBTB43

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZBTB43	hsa-miR-5011-5p	99.2461	NM_014007
ZBTB43	hsa-miR-548p	99.1932	NM_001135776
ZBTB43	hsa-miR-543	99.1022	NM_001135776
ZBTB43	hsa-miR-1236-3p	98.4832	NM_001135776
ZBTB43	hsa-miR-190a-3p	97.7876	NM_014007
ZBTB43	hsa-miR-450b-5p	97.2111	NM_014007
ZBTB43	hsa-miR-6515-3p	97.1926	NM_001135776
ZBTB43	hsa-miR-524-5p	96.1628	NM_001135776
ZBTB43	hsa-miR-513b-5p	96.0566	NM_001135776
ZBTB43	hsa-miR-4719	95.9385	NM_001135776
ZBTB43	hsa-miR-520d-5p	95.6214	NM_001135776
ZBTB43	hsa-miR-10527-5p	95.2742	NM_001135776
ZBTB43	hsa-miR-4279	94.3181	NM_001135776
ZBTB43	hsa-miR-4718	93.9528	NM_001135776
ZBTB43	hsa-miR-1202	93.5077	NM_001135776
ZBTB43	hsa-miR-3972	93.5077	NM_001135776
ZBTB43	hsa-miR-3143	93.0913	NM_014007
ZBTB43	hsa-miR-208b-5p	92.8553	NM_014007
ZBTB43	hsa-miR-208a-5p	92.8553	NM_014007
ZBTB43	hsa-miR-562	92.761	NM_014007
ZBTB43	hsa-miR-548aa	92.6572	NM_014007
ZBTB43	hsa-miR-548ap-3p	92.6572	NM_014007
ZBTB43	hsa-miR-548t-3p	92.6572	NM_014007
ZBTB43	hsa-miR-582-3p	92.4935	NM_001135776
ZBTB43	hsa-miR-6782-3p	92.4824	NM_001135776
ZBTB43	hsa-miR-338-3p	92.2501	NM_001135776
ZBTB43	hsa-miR-4262	92.0331	NM_014007
ZBTB43	hsa-miR-222-5p	91.7264	NM_001135776
ZBTB43	hsa-miR-345-3p	91.6326	NM_001135776
ZBTB43	hsa-miR-6889-3p	90.846	NM_001135776
ZBTB43	hsa-miR-936	90.7851	NM_001135776
ZBTB43	hsa-miR-3120-3p	90.6622	NM_001135776
ZBTB43	hsa-miR-181d-5p	90.6416	NM_014007
ZBTB43	hsa-miR-181c-5p	90.6416	NM_014007
ZBTB43	hsa-miR-181a-5p	90.6416	NM_014007
ZBTB43	hsa-miR-181b-5p	90.6416	NM_014007
ZBTB43	hsa-miR-1976	90.1559	NM_014007
ZBTB43	hsa-miR-502-3p	90.0935	NM_001135776
ZBTB43	hsa-miR-501-3p	90.0935	NM_001135776
ZBTB43	hsa-miR-153-3p	88.3374	NM_001135776
ZBTB43	hsa-miR-4729	88.1864	NM_001135776
ZBTB43	hsa-miR-3622b-3p	87.0874	NM_014007
ZBTB43	hsa-miR-3622a-3p	87.0874	NM_014007
ZBTB43	hsa-miR-4999-5p	87.0585	NM_001135776
ZBTB43	hsa-miR-605-5p	87.05	NM_001135776
ZBTB43	hsa-miR-4456	86.7357	NM_014007
ZBTB43	hsa-miR-2054	86.6717	NM_014007
ZBTB43	hsa-miR-6529-3p	86.6612	NM_001135776
ZBTB43	hsa-miR-4276	85.3735	NM_014007
ZBTB43	hsa-miR-7856-5p	85.278	NM_014007

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Motifs and transcription factors (TFs) regulating ZBTB43

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZBTB43	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ZBTB43	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ZBTB43	hdpi__HIP2	UBE2K (directAnnotation).
ZBTB43	hdpi__NRL	NRL (directAnnotation).
ZBTB43	transfac_pro__M00430	E2F1 (directAnnotation).
ZBTB43	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZBTB43	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
ZBTB43	cisbp__M07938	E2F1 (directAnnotation).
ZBTB43	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ZBTB43	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ZBTB43	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ZBTB43	transfac_pro__M07436	WT1 (directAnnotation).
ZBTB43	transfac_pro__M01837	KLF11 (directAnnotation).
ZBTB43	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZBTB43	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ZBTB43	swissregulon__hs__KLF6	KLF6 (directAnnotation).
ZBTB43	transfac_pro__M00716	ZBTB14 (directAnnotation).
ZBTB43	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ZBTB43	metacluster_163.2	ZNF682 (directAnnotation).
ZBTB43	transfac_pro__M02090	E2F4 (directAnnotation).
ZBTB43	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ZBTB43	metacluster_131.7	down	Mono/Macro	GSE164551	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."