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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: YWHAB

Summary for YWHAB

Gene information	Gene symbol	YWHAB
	Ensembl ID	ENSG00000166913
	Entrez ID	7529
	Gene name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
	Synonyms	YWHAA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: YWHAB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.426338	3.69e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.6425	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.394367	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.428473	2.94e-44
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.383803	2.03e-12
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.318168	4.07e-17
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.406157	3.16e-15
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.451435	2.19e-11
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.296099	9.72e-09
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.317261	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.279669	1.18e-05
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.45788	7.11e-06
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.335449	1.71e-14
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.424819	9.87e-09
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.430272	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.373858	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.25501	7.18e-21
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.409524	1.95e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.506584	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.13016	4.76e-05
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.316207	1.75e-27
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.33829	9.88e-17
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.326044	1.97e-17
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.313687	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.256233	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.418445	1.27e-36
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.723774	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.482078	0.00e+00

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Expression of YWHAB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YWHAB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating YWHAB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YWHAB	hsa-miR-9983-3p	98.1971	NM_003404
YWHAB	hsa-miR-129-5p	97.3579	NM_003404
YWHAB	hsa-miR-148b-3p	95.0157	NM_003404
YWHAB	hsa-miR-152-3p	95.0157	NM_003404
YWHAB	hsa-miR-148a-3p	95.0157	NM_003404
YWHAB	hsa-miR-5690	94.7121	NM_003404
YWHAB	hsa-miR-216a-3p	94.151	NM_003404
YWHAB	hsa-miR-128-3p	94.151	NM_003404
YWHAB	hsa-miR-4682	93.8995	NM_003404
YWHAB	hsa-miR-205-3p	93.7323	NM_003404
YWHAB	hsa-miR-490-5p	93.6321	NM_003404
YWHAB	hsa-miR-3681-3p	93.2324	NM_003404
YWHAB	hsa-miR-873-3p	93.0818	NM_003404
YWHAB	hsa-miR-708-3p	92.6066	NM_003404
YWHAB	hsa-miR-12117	92.1581	NM_003404
YWHAB	hsa-miR-7974	91.7661	NM_003404
YWHAB	hsa-miR-4677-3p	91.4948	NM_003404
YWHAB	hsa-miR-4719	91.1419	NM_003404
YWHAB	hsa-miR-4291	90.6123	NM_003404
YWHAB	hsa-miR-4753-3p	88.4726	NM_003404
YWHAB	hsa-miR-8485	88.3335	NM_003404
YWHAB	hsa-miR-5094	87.8062	NM_003404
YWHAB	hsa-miR-636	87.7427	NM_003404
YWHAB	hsa-miR-670-3p	86.9231	NM_003404
YWHAB	hsa-miR-146a-5p	86.2651	NM_003404
YWHAB	hsa-miR-7153-5p	86.2651	NM_003404
YWHAB	hsa-miR-146b-5p	86.2651	NM_003404
YWHAB	hsa-miR-11399	86.1115	NM_003404
YWHAB	hsa-miR-7152-5p	85.3309	NM_003404
YWHAB	hsa-miR-4255	85.0102	NM_003404
YWHAB	hsa-miR-3920	84.4926	NM_003404
YWHAB	hsa-miR-7844-5p	84.0188	NM_003404
YWHAB	hsa-miR-4789-3p	83.8989	NM_003404
YWHAB	hsa-miR-3617-5p	83.5218	NM_003404
YWHAB	hsa-miR-641	83.5218	NM_003404
YWHAB	hsa-miR-3661	83.2536	NM_003404
YWHAB	hsa-miR-3074-5p	82.973	NM_003404
YWHAB	hsa-miR-200c-3p	82.663	NM_003404
YWHAB	hsa-miR-200b-3p	82.663	NM_003404
YWHAB	hsa-miR-429	82.663	NM_003404
YWHAB	hsa-miR-27b-3p	82.3732	NM_003404
YWHAB	hsa-miR-27a-3p	82.3732	NM_003404
YWHAB	hsa-miR-9985	82.3732	NM_003404
YWHAB	hsa-miR-4282	82.1589	NM_003404
YWHAB	hsa-miR-4778-5p	81.9221	NM_003404
YWHAB	hsa-miR-6511a-5p	81.8845	NM_003404
YWHAB	hsa-miR-1910-3p	81.8845	NM_003404
YWHAB	hsa-miR-1200	81.8537	NM_003404
YWHAB	hsa-miR-670-5p	81.7526	NM_003404
YWHAB	hsa-miR-466	81.5234	NM_003404

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Motifs and transcription factors (TFs) regulating YWHAB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YWHAB	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
YWHAB	swissregulon__hs__SPI1	SPI1 (directAnnotation).
YWHAB	transfac_pro__M02269	FEV (directAnnotation).
YWHAB	homer__ACAGGATGTGGT_ETS_RUNX	RUNX1 (directAnnotation).
YWHAB	tfdimers__MD00066	ELF1 (directAnnotation).
YWHAB	metacluster_2.4	ZIM3; ZIM3; ZIM3; ZIM3 (directAnnotation).
YWHAB	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
YWHAB	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
YWHAB	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
YWHAB	jaspar__MA0748.2	YY2 (directAnnotation).
YWHAB	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
YWHAB	transfac_pro__M06280	ZFP69 (directAnnotation).
YWHAB	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
YWHAB	swissregulon__hs__ETV6	ETV6 (directAnnotation).
YWHAB	metacluster_183.3	EHF; ELF3; FLI1; SPIB (directAnnotation). EHF; EHF; ELF2; ELF3; ELF4; ELF5; ERG; ERG; ETV3; ETV6; FLI1; SPI1; SPI1 (inferredBy_Orthology).
YWHAB	metacluster_183.4	ETS1 (inferredBy_Orthology).
YWHAB	transfac_pro__M00655	ETV4 (directAnnotation).
YWHAB	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
YWHAB	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
YWHAB	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
YWHAB	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
YWHAB	cisbp__M00249	WT1 (directAnnotation).
YWHAB	transfac_pro__M01122	ZNF219 (directAnnotation).
YWHAB	metacluster_151.2	ZNF23 (directAnnotation).
YWHAB	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
YWHAB	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
YWHAB	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
YWHAB	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
YWHAB	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
YWHAB	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
YWHAB	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
YWHAB	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
YWHAB	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
YWHAB	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
YWHAB	transfac_pro__M01253	CNOT3 (directAnnotation).
YWHAB	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
YWHAB	metacluster_3.10	KLF2; KLF4 (directAnnotation).
YWHAB	jaspar__MA1721.1	ZNF93 (directAnnotation).
YWHAB	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
YWHAB	transfac_pro__M01199	TRIM28 (directAnnotation).
YWHAB	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
YWHAB	tfdimers__MD00391	KLF4 (directAnnotation).
YWHAB	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
YWHAB	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
YWHAB	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
YWHAB	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
YWHAB	cisbp__M00968	MTF2 (directAnnotation).
YWHAB	transfac_pro__M12697	ZNF142 (directAnnotation).
YWHAB	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
YWHAB	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
YWHAB	"Copper"	DB09130	small molecule
YWHAB	"Phenethyl Isothiocyanate"	DB12695	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."