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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: VPS13C

Summary for VPS13C

Gene informationGene symbol

VPS13C

Ensembl ID

ENSG00000129003

Entrez ID

54832

Gene namevacuolar protein sorting 13 homolog C
SynonymsBLTP5C|FLJ10381|FLJ20136|KIAA1421
Gene typeprotein_coding
UniProtAcc

Q709C8


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Dataset with differentially expressed gene: VPS13C

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD4+ T cells0.3623170.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreNK cells0.3364780.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro0.28110.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells0.3912250.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostMono/Macro-0.2703863.46e-36

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMalignant cells0.3187810.00e+00

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells0.2714720.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreB cells-0.6630691.85e-02

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.3087681.64e-19

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.4269940.00e+00

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Expression of VPS13C in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to VPS13C

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VPS13C

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
VPS13Chsa-miR-511-3p99.9872NM_001018088
VPS13Chsa-miR-5011-5p99.9868NM_001018088
VPS13Chsa-miR-190a-3p99.9228NM_001018088
VPS13Chsa-miR-29799.4034NM_018080
VPS13Chsa-miR-1213298.6794NM_001018088
VPS13Chsa-miR-6867-5p98.4061NM_018080
VPS13Chsa-miR-223-5p98.2883NM_018080
VPS13Chsa-miR-10527-5p97.4451NM_001018088
VPS13Chsa-miR-480396.917NM_018080
VPS13Chsa-miR-392496.0269NM_018080
VPS13Chsa-miR-56795.8669NM_018080
VPS13Chsa-miR-451b95.6221NM_017684
VPS13Chsa-miR-3613-3p95.3381NM_017684
VPS13Chsa-miR-548e-5p95.0611NM_001018088
VPS13Chsa-miR-6833-3p94.8656NM_017684
VPS13Chsa-miR-452194.4198NM_018080
VPS13Chsa-miR-410-3p93.8452NM_018080
VPS13Chsa-miR-4768-5p93.7582NM_017684
VPS13Chsa-miR-290993.2584NM_017684
VPS13Chsa-miR-218-5p92.9683NM_001018088
VPS13Chsa-miR-548x-3p92.3809NM_017684
VPS13Chsa-miR-548aj-3p92.3809NM_017684
VPS13Chsa-miR-7856-5p92.116NM_001018088
VPS13Chsa-miR-541-5p91.5386NM_001018088
VPS13Chsa-miR-3177-5p91.537NM_018080
VPS13Chsa-miR-431491.4904NM_017684
VPS13Chsa-miR-548j-3p91.403NM_017684
VPS13Chsa-miR-548ah-3p91.403NM_017684
VPS13Chsa-miR-548ae-3p91.403NM_017684
VPS13Chsa-miR-548am-3p91.403NM_017684
VPS13Chsa-miR-548aq-3p91.403NM_017684
VPS13Chsa-miR-4753-3p91.3707NM_017684
VPS13Chsa-miR-5692b90.5427NM_018080
VPS13Chsa-miR-5692c90.5427NM_018080
VPS13Chsa-miR-532-5p88.8471NM_017684
VPS13Chsa-miR-208a-3p88.8025NM_018080
VPS13Chsa-miR-1277-5p88.2319NM_018080
VPS13Chsa-miR-428288.1625NM_001018088
VPS13Chsa-miR-373-5p88.0319NM_001018088
VPS13Chsa-miR-371b-5p88.0319NM_001018088
VPS13Chsa-miR-616-5p88.0319NM_001018088
VPS13Chsa-miR-5007-3p87.983NM_017684
VPS13Chsa-miR-10397-5p87.8945NM_018080
VPS13Chsa-miR-561-3p87.5307NM_017684
VPS13Chsa-miR-450387.2155NM_017684
VPS13Chsa-miR-126-5p86.9933NM_018080
VPS13Chsa-miR-314885.8611NM_018080
VPS13Chsa-miR-4774-3p85.4115NM_018080
VPS13Chsa-miR-4477b85.4032NM_001018088
VPS13Chsa-miR-330-3p85.3408NM_017684
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Motifs and transcription factors (TFs) regulating VPS13C

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
VPS13Ccisbp__M00343PAX6 (directAnnotation).
VPS13Ctaipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAPETV5; HES7 (directAnnotation).
VPS13Ctaipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_reprHES7; TFAP2C (directAnnotation).
VPS13Ctransfac_pro__M12694ZFP14 (directAnnotation).
VPS13Cmetacluster_115.1NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
VPS13Ckznf__ZNF90_Imbeault2017_OM_RCADEZNF90 (directAnnotation).
VPS13Cswissregulon__hs__CHD1CHD1 (directAnnotation).
VPS13Ctransfac_pro__M02898SMAD3 (directAnnotation).
VPS13Ctransfac_pro__M07387ZBTB7A (directAnnotation).
VPS13Ckznf__ZNF2_Imbeault2017_RP_ChIP-seqZNF2 (directAnnotation).
VPS13Ccisbp__M00775ZBTB1 (inferredBy_Orthology).
VPS13Ctransfac_pro__M09837ZNF449 (directAnnotation).
VPS13Ctransfac_pro__M00430E2F1 (directAnnotation).
VPS13Chdpi__EBF1EBF1 (directAnnotation).
VPS13Cjaspar__MA1122.1TFDP1 (directAnnotation).
VPS13Ckznf__ZNF311_Imbeault2017_RP_ChIP-seqZNF311 (directAnnotation).
VPS13Chdpi__GTF3C2GTF3C2 (directAnnotation).
VPS13Cjaspar__MA1721.1ZNF93 (directAnnotation).
VPS13Ctransfac_pro__M08005TCFL5 (inferredBy_Orthology).
VPS13Ckznf__ZNF548_Imbeault2017_OM_RCADEZNF548 (directAnnotation).
VPS13Ctransfac_pro__M03876ZBTB33 (directAnnotation).
VPS13Ctransfac_pro__M04646FOXN4 (directAnnotation).
VPS13Cmetacluster_126.2ZBTB4; ZBTB4 (directAnnotation).
VPS13Ckznf__ZBTB14_Schmitges2016_RCADEZBTB14 (directAnnotation).
VPS13Ckznf__ZNF2_Imbeault2017_OM_RCADEZNF2 (directAnnotation).
VPS13Ckznf__ZNF383_Imbeault2017_OM_RCADEZNF383 (directAnnotation).
VPS13Ctaipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
VPS13Ctransfac_pro__M07329SP7 (directAnnotation).
VPS13Ctransfac_pro__M04617ZBTB7A (directAnnotation).
VPS13Ctransfac_pro__M07436WT1 (directAnnotation).
VPS13Cmetacluster_66.4ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
VPS13Ctransfac_pro__M04877GTF3C2 (directAnnotation).
VPS13Ccisbp__M01733CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
VPS13Ctransfac_public__M00005TFAP4 (directAnnotation).
VPS13Ctransfac_pro__M01238DEAF1 (inferredBy_Orthology).
VPS13Cmetacluster_135.1ZNF561 (directAnnotation).
VPS13Ctaipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_reprZBTB37 (directAnnotation).
VPS13Cmetacluster_35.2EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
VPS13Ctransfac_pro__M01783SP2 (directAnnotation).
VPS13Cdbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1ZBTB8A (directAnnotation).
VPS13Ctaipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_reprHES7; TFAP2C (directAnnotation).
VPS13Ctaipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAPETV5; HES7 (directAnnotation).
VPS13Ctransfac_pro__M07437ZBTB2 (directAnnotation).
VPS13Cmetacluster_15.2E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
VPS13Chomer__GGCGGGAARN_E2F6E2F6 (directAnnotation).
VPS13Chomer__NANTGCSGCA_Zfp57ZFP57 (directAnnotation).
VPS13Cmetacluster_3.11SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
VPS13Cmetacluster_15.3E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
VPS13Cmetacluster_3.7SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
VPS13Cmetacluster_3.14WT1; WT1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."