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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP12

Summary for USP12

Gene information	Gene symbol	USP12
	Ensembl ID	ENSG00000152484
	Entrez ID	219333
	Gene name	ubiquitin specific peptidase 12
	Synonyms	USP12L1
	Gene type	protein_coding
	UniProtAcc	O75317

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Dataset with differentially expressed gene: USP12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.399272	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.720469	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.286398	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.910094	0.00e+00

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Expression of USP12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP12	hsa-miR-3148	97.3056	NM_182488
USP12	hsa-miR-6724-5p	96.406	NM_182488
USP12	hsa-miR-6773-5p	96.3665	NM_182488
USP12	hsa-let-7b-3p	94.1184	NM_182488
USP12	hsa-let-7f-1-3p	94.1184	NM_182488
USP12	hsa-let-7a-3p	94.1184	NM_182488
USP12	hsa-miR-98-3p	94.1184	NM_182488
USP12	hsa-miR-1827	94.0961	NM_182488
USP12	hsa-miR-381-3p	93.9447	NM_182488
USP12	hsa-miR-300	93.9447	NM_182488
USP12	hsa-miR-4699-3p	93.5233	NM_182488
USP12	hsa-miR-4666a-3p	92.8337	NM_182488
USP12	hsa-miR-130a-5p	92.6524	NM_182488
USP12	hsa-miR-12136	92.4788	NM_182488
USP12	hsa-miR-7106-3p	92.4612	NM_182488
USP12	hsa-miR-4762-3p	92.2682	NM_182488
USP12	hsa-miR-3675-3p	91.758	NM_182488
USP12	hsa-miR-9986	90.904	NM_182488
USP12	hsa-miR-1294	90.904	NM_182488
USP12	hsa-miR-548m	90.0406	NM_182488
USP12	hsa-miR-6820-3p	89.4555	NM_182488
USP12	hsa-miR-3164	89.4555	NM_182488
USP12	hsa-miR-656-3p	89.2185	NM_182488
USP12	hsa-miR-548n	88.277	NM_182488
USP12	hsa-miR-4795-3p	88.0788	NM_182488
USP12	hsa-miR-548l	88.072	NM_182488
USP12	hsa-miR-6830-5p	88.0548	NM_182488
USP12	hsa-miR-4775	87.9084	NM_182488
USP12	hsa-miR-6757-3p	87.2942	NM_182488
USP12	hsa-miR-3919	86.3166	NM_182488
USP12	hsa-miR-4771	86.0765	NM_182488
USP12	hsa-miR-5692a	85.6229	NM_182488
USP12	hsa-miR-4709-5p	85.5367	NM_182488
USP12	hsa-miR-651-3p	84.99	NM_182488
USP12	hsa-miR-32-3p	84.9558	NM_182488
USP12	hsa-miR-4476	84.6556	NM_182488
USP12	hsa-miR-6876-5p	84.6556	NM_182488
USP12	hsa-miR-8080	84.1711	NM_182488
USP12	hsa-miR-190a-3p	83.9449	NM_182488
USP12	hsa-miR-126-5p	83.7023	NM_182488
USP12	hsa-miR-6515-3p	83.5504	NM_182488
USP12	hsa-miR-20a-3p	83.3747	NM_182488
USP12	hsa-miR-6809-3p	83.301	NM_182488
USP12	hsa-miR-2110	83.0394	NM_182488
USP12	hsa-let-7c-3p	83.0032	NM_182488
USP12	hsa-miR-4524b-5p	82.9185	NM_182488
USP12	hsa-miR-4524a-5p	82.9185	NM_182488
USP12	hsa-miR-296-5p	82.5107	NM_182488
USP12	hsa-miR-365a-5p	82.4995	NM_182488
USP12	hsa-miR-365b-5p	82.4995	NM_182488

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Motifs and transcription factors (TFs) regulating USP12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP12	transfac_pro__M00514	ATF4 (directAnnotation).
USP12	transfac_pro__M00665	SP3 (directAnnotation).
USP12	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
USP12	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
USP12	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
USP12	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
USP12	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
USP12	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
USP12	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
USP12	transfac_pro__M07329	SP7 (directAnnotation).
USP12	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
USP12	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
USP12	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
USP12	metacluster_182.10	ZFX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."