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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBXN4

Summary for UBXN4

Gene information	Gene symbol	UBXN4
	Ensembl ID	ENSG00000144224
	Entrez ID	23190
	Gene name	UBX domain protein 4
	Synonyms	KIAA0242\|UBXD2\|UBXDC1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: UBXN4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.325687	6.41e-22
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.330323	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.522475	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.324382	8.58e-04
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.367346	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.293657	6.47e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.466982	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.263156	1.18e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.873993	2.09e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.280726	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.304137	1.74e-14
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.373452	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.828082	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.348912	0.00e+00

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Expression of UBXN4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBXN4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBXN4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBXN4	hsa-miR-367-3p	95.2889	NM_014607
UBXN4	hsa-miR-25-3p	95.2889	NM_014607
UBXN4	hsa-miR-363-3p	95.2889	NM_014607
UBXN4	hsa-miR-92b-3p	95.1938	NM_014607
UBXN4	hsa-miR-32-5p	95.1938	NM_014607
UBXN4	hsa-miR-92a-3p	95.1938	NM_014607
UBXN4	hsa-miR-3682-5p	94.0062	NM_014607
UBXN4	hsa-miR-4311	93.3039	NM_014607
UBXN4	hsa-miR-2053	92.274	NM_014607
UBXN4	hsa-miR-656-5p	92.1527	NM_014607
UBXN4	hsa-miR-548x-3p	88.8355	NM_014607
UBXN4	hsa-miR-548aj-3p	88.8355	NM_014607
UBXN4	hsa-miR-519e-5p	88.481	NM_014607
UBXN4	hsa-miR-515-5p	88.481	NM_014607
UBXN4	hsa-miR-5190	87.798	NM_014607
UBXN4	hsa-miR-5003-3p	87.7592	NM_014607
UBXN4	hsa-miR-1228-3p	87.7226	NM_014607
UBXN4	hsa-miR-548ah-3p	86.7035	NM_014607
UBXN4	hsa-miR-548am-3p	86.7035	NM_014607
UBXN4	hsa-miR-548j-3p	86.7035	NM_014607
UBXN4	hsa-miR-548ae-3p	86.7035	NM_014607
UBXN4	hsa-miR-548aq-3p	86.7035	NM_014607
UBXN4	hsa-miR-5691	85.8242	NM_014607
UBXN4	hsa-miR-4288	85.4387	NM_014607
UBXN4	hsa-miR-4279	85.1986	NM_014607
UBXN4	hsa-miR-4762-3p	84.6121	NM_014607
UBXN4	hsa-miR-3925-3p	82.9838	NM_014607
UBXN4	hsa-miR-3668	81.7583	NM_014607
UBXN4	hsa-miR-4302	81.1275	NM_014607
UBXN4	hsa-miR-6805-3p	80.9268	NM_014607
UBXN4	hsa-miR-6891-3p	80.7437	NM_014607
UBXN4	hsa-miR-6824-5p	80.5019	NM_014607
UBXN4	hsa-miR-4700-5p	80.4973	NM_014607
UBXN4	hsa-miR-8089	80.4973	NM_014607
UBXN4	hsa-miR-4667-5p	80.4973	NM_014607

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Motifs and transcription factors (TFs) regulating UBXN4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBXN4	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
UBXN4	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
UBXN4	jaspar__MA1122.1	TFDP1 (directAnnotation).
UBXN4	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
UBXN4	tfdimers__MD00391	KLF4 (directAnnotation).
UBXN4	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
UBXN4	transfac_pro__M12697	ZNF142 (directAnnotation).
UBXN4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UBXN4	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
UBXN4	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
UBXN4	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
UBXN4	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
UBXN4	swissregulon__hs__ELK1	ELK1 (directAnnotation).
UBXN4	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
UBXN4	transfac_pro__M04862	NRF1 (directAnnotation).
UBXN4	transfac_pro__M04748	GABPA (directAnnotation).
UBXN4	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
UBXN4	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
UBXN4	transfac_pro__M06615	ZNF597 (directAnnotation).
UBXN4	metacluster_35.10	ZNF681; ZNF681 (directAnnotation).
UBXN4	transfac_pro__M06764	ZNF112 (directAnnotation).
UBXN4	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
UBXN4	transfac_pro__M06735	ZKSCAN7 (directAnnotation).
UBXN4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
UBXN4	hdpi__HIP2	UBE2K (directAnnotation).
UBXN4	hdpi__NRL	NRL (directAnnotation).
UBXN4	transfac_pro__M00430	E2F1 (directAnnotation).
UBXN4	transfac_pro__M07329	SP7 (directAnnotation).
UBXN4	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
UBXN4	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
UBXN4	transfac_pro__M01837	KLF11 (directAnnotation).
UBXN4	transfac_pro__M07310	SP5 (directAnnotation).
UBXN4	transfac_pro__M04817	ZBTB33 (directAnnotation).
UBXN4	swissregulon__hs__KLF6	KLF6 (directAnnotation).
UBXN4	transfac_pro__M00716	ZBTB14 (directAnnotation).
UBXN4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
UBXN4	metacluster_163.2	ZNF682 (directAnnotation).
UBXN4	transfac_pro__M04916	TAF1 (directAnnotation).
UBXN4	transfac_pro__M00938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."