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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SSH2

Summary for SSH2

Gene information	Gene symbol	SSH2
	Ensembl ID	ENSG00000141298
	Entrez ID	85464
	Gene name	slingshot protein phosphatase 2
	Synonyms	KIAA1725
	Gene type	protein_coding
	UniProtAcc	Q76I76

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Dataset with differentially expressed gene: SSH2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.319133	8.72e-29
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.360663	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.345153	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.413854	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.261872	2.81e-05
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.342593	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.538475	1.44e-27
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.268915	3.45e-39
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	0.378257	2.09e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.487732	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.259584	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.314901	0.00e+00

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Expression of SSH2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SSH2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SSH2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SSH2	hsa-miR-3662	99.2719	NM_001282129
SSH2	hsa-miR-4698	98.483	NM_001282129
SSH2	hsa-miR-3686	97.8047	NM_033389
SSH2	hsa-miR-4533	96.8481	NM_001282129
SSH2	hsa-miR-4736	96.8119	NM_001282129
SSH2	hsa-miR-493-5p	96.6943	NM_001282129
SSH2	hsa-miR-5195-3p	96.576	NM_001282129
SSH2	hsa-miR-145-5p	96.576	NM_001282129
SSH2	hsa-miR-8485	96.2371	NM_033389
SSH2	hsa-miR-132-3p	96.2038	NM_001282129
SSH2	hsa-miR-212-3p	96.2038	NM_001282129
SSH2	hsa-miR-548an	96.1241	NM_001282129
SSH2	hsa-miR-3202	95.7185	NM_033389
SSH2	hsa-miR-6808-5p	95.6368	NM_001282129
SSH2	hsa-miR-1207-5p	95.6228	NM_001282129
SSH2	hsa-miR-4272	95.0431	NM_001282129
SSH2	hsa-miR-4763-3p	94.9951	NM_001282129
SSH2	hsa-miR-6893-5p	94.3978	NM_001282129
SSH2	hsa-miR-940	94.2436	NM_001282129
SSH2	hsa-miR-1297	93.9917	NM_001282129
SSH2	hsa-miR-1252-3p	93.6564	NM_033389
SSH2	hsa-miR-105-5p	93.5947	NM_033389
SSH2	hsa-miR-7853-5p	93.5947	NM_033389
SSH2	hsa-miR-938	93.4631	NM_001282129
SSH2	hsa-miR-6876-5p	93.057	NM_001282129
SSH2	hsa-miR-4476	93.057	NM_001282129
SSH2	hsa-miR-3910	92.8566	NM_001282130
SSH2	hsa-miR-26a-5p	92.4024	NM_001282129
SSH2	hsa-miR-26b-5p	92.4024	NM_001282129
SSH2	hsa-miR-8063	92.3914	NM_001282129
SSH2	hsa-miR-4282	92.2573	NM_033389
SSH2	hsa-miR-365b-3p	92.1844	NM_001282129
SSH2	hsa-miR-365a-3p	92.1844	NM_001282129
SSH2	hsa-miR-20a-5p	91.9329	NM_001282129
SSH2	hsa-miR-106b-5p	91.9329	NM_001282129
SSH2	hsa-miR-526b-3p	91.6001	NM_001282129
SSH2	hsa-miR-4465	91.4591	NM_001282129
SSH2	hsa-miR-3616-3p	91.0639	NM_033389
SSH2	hsa-miR-3148	91.0544	NM_001282129
SSH2	hsa-miR-3194-3p	91.0166	NM_001282129
SSH2	hsa-miR-12123	90.959	NM_001282129
SSH2	hsa-miR-548aj-3p	90.6249	NM_033389
SSH2	hsa-miR-548x-3p	90.6249	NM_033389
SSH2	hsa-miR-7150	90.5721	NM_001282129
SSH2	hsa-miR-30e-5p	90.4522	NM_001282129
SSH2	hsa-miR-30d-5p	90.4522	NM_001282129
SSH2	hsa-miR-30b-5p	90.4522	NM_001282129
SSH2	hsa-miR-30a-5p	90.4522	NM_001282129
SSH2	hsa-miR-30c-5p	90.4522	NM_001282129
SSH2	hsa-miR-93-5p	90.2532	NM_001282129

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Motifs and transcription factors (TFs) regulating SSH2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SSH2	metacluster_84.2	RARA (directAnnotation).
SSH2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SSH2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
SSH2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SSH2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SSH2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SSH2	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
SSH2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SSH2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
SSH2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SSH2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
SSH2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
SSH2	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
SSH2	tfdimers__MD00151	CHURC1 (directAnnotation).
SSH2	tfdimers__MD00391	KLF4 (directAnnotation).
SSH2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
SSH2	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
SSH2	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
SSH2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SSH2	transfac_pro__M01973	PLAG1 (directAnnotation).
SSH2	transfac_pro__M12697	ZNF142 (directAnnotation).
SSH2	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
SSH2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SSH2	transfac_pro__M01303	SP1 (directAnnotation).
SSH2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SSH2	metacluster_3.14	WT1; WT1 (directAnnotation).
SSH2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SSH2	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
SSH2	transfac_public__M00491	PATZ1 (directAnnotation).
SSH2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SSH2	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
SSH2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
SSH2	transfac_pro__M07397	ZNF148 (directAnnotation).
SSH2	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
SSH2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
SSH2	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
SSH2	metacluster_172.26	ZSCAN29 (directAnnotation).
SSH2	transfac_pro__M06857	ZNF611 (directAnnotation).
SSH2	taipale_tf_pairs__CUX1_TBX21_NTCACACMNNNATCRATN_CAP_repr	CUX1; TBX21 (directAnnotation).
SSH2	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
SSH2	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
SSH2	metacluster_123.4	IRX3; ZNF157 (directAnnotation).
SSH2	transfac_pro__M06534	ZNF563 (directAnnotation).
SSH2	metacluster_155.34	PRDM4 (directAnnotation).
SSH2	taipale_tf_pairs__ETV2_RFX5_NACTTCCGGYNNNNGCAACSN_CAP_repr	ETV2; RFX5 (directAnnotation).
SSH2	transfac_pro__M05993	ZNF711 (directAnnotation).
SSH2	metacluster_131.3	ZNF436 (inferredBy_Orthology).
SSH2	jaspar__MA0131.2	HINFP (directAnnotation).
SSH2	transfac_pro__M05737	ZNF699 (directAnnotation).
SSH2	tfdimers__MD00364	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."