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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SRSF4

Summary for SRSF4

Gene information	Gene symbol	SRSF4
	Ensembl ID	ENSG00000116350
	Entrez ID	6429
	Gene name	serine and arginine rich splicing factor 4
	Synonyms	SFRS4\|SRP75
	Gene type	protein_coding
	UniProtAcc	Q08170

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Dataset with differentially expressed gene: SRSF4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.452694	9.48e-29
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.317912	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.333586	1.78e-10
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.351561	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.289906	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.281625	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.290733	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.34297	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.372256	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.255054	1.53e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.398721	1.14e-25
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.323283	6.04e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.535957	0.00e+00

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Expression of SRSF4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SRSF4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SRSF4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SRSF4	hsa-miR-548p	98.7162	NM_005626
SRSF4	hsa-miR-362-3p	96.2572	NM_005626
SRSF4	hsa-miR-329-3p	96.2572	NM_005626
SRSF4	hsa-miR-335-5p	95.6183	NM_005626
SRSF4	hsa-miR-627-3p	95.4456	NM_005626
SRSF4	hsa-miR-513b-5p	94.8133	NM_005626
SRSF4	hsa-miR-3163	91.978	NM_005626
SRSF4	hsa-miR-6849-3p	89.331	NM_005626
SRSF4	hsa-miR-147b-5p	88.1756	NM_005626
SRSF4	hsa-miR-6512-3p	87.9579	NM_005626
SRSF4	hsa-miR-6720-5p	87.9579	NM_005626
SRSF4	hsa-miR-8087	87.3469	NM_005626
SRSF4	hsa-miR-4296	86.61	NM_005626
SRSF4	hsa-miR-6828-5p	86.4905	NM_005626
SRSF4	hsa-miR-607	86.0265	NM_005626
SRSF4	hsa-let-7c-3p	86.0028	NM_005626
SRSF4	hsa-miR-4261	85.7926	NM_005626
SRSF4	hsa-miR-5003-5p	84.7711	NM_005626
SRSF4	hsa-miR-12123	84.5534	NM_005626
SRSF4	hsa-miR-30a-3p	82.0969	NM_005626
SRSF4	hsa-miR-30d-3p	82.0969	NM_005626
SRSF4	hsa-miR-30e-3p	82.0969	NM_005626
SRSF4	hsa-miR-139-5p	81.2615	NM_005626
SRSF4	hsa-miR-4755-3p	80.6553	NM_005626
SRSF4	hsa-miR-4696	80.3252	NM_005626

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Motifs and transcription factors (TFs) regulating SRSF4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SRSF4	transfac_pro__M02090	E2F4 (directAnnotation).
SRSF4	metacluster_45.4	E2F2 (directAnnotation).
SRSF4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SRSF4	metacluster_175.1	ZNF283 (directAnnotation).
SRSF4	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
SRSF4	cisbp__M00343	PAX6 (directAnnotation).
SRSF4	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
SRSF4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SRSF4	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
SRSF4	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
SRSF4	swissregulon__hs__KLF6	KLF6 (directAnnotation).
SRSF4	transfac_pro__M02898	SMAD3 (directAnnotation).
SRSF4	transfac_pro__M07387	ZBTB7A (directAnnotation).
SRSF4	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
SRSF4	transfac_pro__M00430	E2F1 (directAnnotation).
SRSF4	hdpi__EBF1	EBF1 (directAnnotation).
SRSF4	tfdimers__MD00364	WT1 (directAnnotation).
SRSF4	hdpi__GTF3C2	GTF3C2 (directAnnotation).
SRSF4	metacluster_198.3	ZFP64 (directAnnotation).
SRSF4	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
SRSF4	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SRSF4	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
SRSF4	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
SRSF4	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
SRSF4	transfac_pro__M05993	ZNF711 (directAnnotation).
SRSF4	transfac_pro__M06331	ZNF343 (directAnnotation).
SRSF4	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SRSF4	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
SRSF4	transfac_public__M00005	TFAP4 (directAnnotation).
SRSF4	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).
SRSF4	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
SRSF4	jaspar__MA0131.2	HINFP (directAnnotation).
SRSF4	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
SRSF4	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
SRSF4	metacluster_135.11	NR2C2 (directAnnotation).
SRSF4	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
SRSF4	transfac_pro__M07437	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SRSF4	"Artenimol"	DB11638	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."