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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: SP3

Summary for SP3

Gene information	Gene symbol	SP3
	Ensembl ID	ENSG00000172845
	Entrez ID	6670
	Gene name	Sp3 transcription factor
	Synonyms	SPR-2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.459442	8.04e-43
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.285867	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.299083	1.12e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.31849	0.00e+00

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Expression of SP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SP3	hsa-miR-493-5p	99.9387	NM_001017371
SP3	hsa-miR-8063	99.3786	NM_001017371
SP3	hsa-miR-6733-3p	99.2623	NM_001172712
SP3	hsa-miR-223-3p	99.0186	NM_001172712
SP3	hsa-miR-4282	98.9365	NM_001017371
SP3	hsa-miR-4698	98.9175	NM_001017371
SP3	hsa-miR-154-3p	98.7357	NM_001017371
SP3	hsa-miR-487a-3p	98.7357	NM_001017371
SP3	hsa-miR-4716-5p	98.6346	NM_001172712
SP3	hsa-miR-200b-5p	98.5343	NM_001172712
SP3	hsa-miR-200a-5p	98.5343	NM_001172712
SP3	hsa-miR-1305	98.1813	NM_001017371
SP3	hsa-let-7c-3p	97.9674	NM_001017371
SP3	hsa-let-7a-2-3p	97.9674	NM_001017371
SP3	hsa-let-7g-3p	97.9674	NM_001017371
SP3	hsa-miR-4753-3p	97.8845	NM_001172712
SP3	hsa-miR-524-5p	97.7346	NM_001017371
SP3	hsa-miR-4659a-3p	97.7131	NM_001017371
SP3	hsa-miR-4659b-3p	97.7131	NM_001017371
SP3	hsa-miR-497-3p	97.5486	NM_001017371
SP3	hsa-miR-4511	97.4997	NM_001172712
SP3	hsa-miR-338-5p	97.1143	NM_001017371
SP3	hsa-miR-520d-5p	96.92	NM_001017371
SP3	hsa-miR-548c-3p	96.9104	NM_001017371
SP3	hsa-miR-2681-5p	96.8143	NM_001017371
SP3	hsa-miR-548ar-3p	96.7758	NM_001172712
SP3	hsa-miR-7856-5p	96.6171	NM_001172712
SP3	hsa-miR-4676-3p	96.3896	NM_001172712
SP3	hsa-miR-452-5p	96.3896	NM_001172712
SP3	hsa-miR-892c-3p	96.3896	NM_001172712
SP3	hsa-miR-548az-3p	96.3378	NM_001172712
SP3	hsa-miR-548bc	95.7944	NM_001172712
SP3	hsa-miR-548a-3p	95.7944	NM_001172712
SP3	hsa-miR-548f-3p	95.7944	NM_001172712
SP3	hsa-miR-548e-3p	95.7944	NM_001172712
SP3	hsa-miR-12136	94.7485	NM_001017371
SP3	hsa-miR-607	94.6618	NM_001017371
SP3	hsa-miR-488-3p	94.6215	NM_001017371
SP3	hsa-miR-3680-3p	94.404	NM_001017371
SP3	hsa-miR-7159-3p	94.2059	NM_001172712
SP3	hsa-miR-6809-3p	94.0525	NM_001172712
SP3	hsa-miR-182-5p	93.96	NM_001017371
SP3	hsa-miR-6792-3p	93.944	NM_001017371
SP3	hsa-miR-507	93.4394	NM_001172712
SP3	hsa-miR-153-5p	93.3277	NM_001172712
SP3	hsa-miR-548t-3p	92.9933	NM_001172712
SP3	hsa-miR-548ap-3p	92.9933	NM_001172712
SP3	hsa-miR-548aa	92.9933	NM_001172712
SP3	hsa-miR-410-3p	92.8543	NM_001017371
SP3	hsa-miR-4697-3p	92.6845	NM_001172712

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Motifs and transcription factors (TFs) regulating SP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SP3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SP3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SP3	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
SP3	metacluster_182.10	ZFX (directAnnotation).
SP3	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SP3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SP3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
SP3	hdpi__TIMELESS	TIMELESS (directAnnotation).
SP3	metacluster_191.5	SPDEF (inferredBy_Orthology).
SP3	hdpi__TP73	TP73 (directAnnotation).
SP3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SP3	hdpi__ELF2	ELF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
SP3	metacluster_3.11	up	Malignant cells	GSE138267	NA
SP3	metacluster_3.7	up	Malignant cells	GSE138267	NA
SP3	metacluster_3.4	up	Malignant cells	GSE138267	NA
SP3	transfac_pro__M00665	down	Malignant cells	GSE199333	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."