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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SNX10

Summary for SNX10

Gene information	Gene symbol	SNX10
	Ensembl ID	ENSG00000086300
	Entrez ID	29887
	Gene name	sorting nexin 10
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9Y5X0

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Dataset with differentially expressed gene: SNX10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.881752	8.98e-07
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.261414	2.38e-14
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.591904	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.423033	4.69e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.581659	2.93e-07
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Mono/Macro	-0.250082	1.58e-32
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.429877	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.27149	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.534248	5.55e-29
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.58357	0.00e+00

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Expression of SNX10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SNX10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SNX10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SNX10	hsa-miR-4799-5p	97.7164	NM_001199837
SNX10	hsa-miR-582-5p	95.7427	NM_001199837
SNX10	hsa-miR-551b-5p	95.0944	NM_001199837
SNX10	hsa-miR-4263	95.0631	NM_001318199
SNX10	hsa-miR-7152-5p	93.4119	NM_001199837
SNX10	hsa-miR-513a-5p	93.1738	NM_001199837
SNX10	hsa-miR-4775	91.3665	NM_001199837
SNX10	hsa-miR-27b-3p	91.3413	NM_001199837
SNX10	hsa-miR-9985	91.3413	NM_001199837
SNX10	hsa-miR-27a-3p	91.3413	NM_001199837
SNX10	hsa-miR-30e-5p	90.2722	NM_001318199
SNX10	hsa-miR-30c-5p	90.2722	NM_001318199
SNX10	hsa-miR-30a-5p	90.2722	NM_001318199
SNX10	hsa-miR-30b-5p	90.2722	NM_001318199
SNX10	hsa-miR-30d-5p	90.2722	NM_001318199
SNX10	hsa-miR-576-5p	89.2994	NM_001318199
SNX10	hsa-miR-3658	88.5329	NM_001199837
SNX10	hsa-miR-802	88.2622	NM_001199837
SNX10	hsa-miR-6509-5p	87.0214	NM_001199837
SNX10	hsa-miR-7161-5p	86.4114	NM_001199837
SNX10	hsa-miR-548u	85.5258	NM_001199837
SNX10	hsa-miR-587	85.5065	NM_001318199
SNX10	hsa-miR-942-5p	82.2885	NM_001199837
SNX10	hsa-miR-627-3p	81.748	NM_001318199
SNX10	hsa-miR-4495	81.3464	NM_001318199
SNX10	hsa-miR-570-3p	81.1114	NM_001199837
SNX10	hsa-miR-33a-3p	81.0661	NM_001199837
SNX10	hsa-miR-6504-3p	80.0803	NM_001199837
SNX10	hsa-miR-10399-5p	80.0803	NM_001199837

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Motifs and transcription factors (TFs) regulating SNX10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SNX10	metacluster_22.19	NFE2 (directAnnotation).
SNX10	metacluster_22.32	NFE2L2 (directAnnotation).
SNX10	metacluster_147.3	MGA; MGA; TBX1; TBX15; TBX15; TBX18; TBX19; TBX20; TBX20; TBX20; TBX21; TBX22; ZNF18; ZNF18; ZNF18; ZNF18 (directAnnotation). MGA; TBX21 (inferredBy_Orthology).
SNX10	kznf__ZNF547_Imbeault2017_OM_MEME	ZNF547 (directAnnotation).
SNX10	metacluster_22.36	BACH2 (directAnnotation).
SNX10	transfac_pro__M05612	ZNF189 (directAnnotation).
SNX10	transfac_pro__M06042	ZNF208 (directAnnotation).
SNX10	transfac_public__M00208	NFKB1; RELA (directAnnotation).
SNX10	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
SNX10	transfac_pro__M06402	ZNF493 (directAnnotation).
SNX10	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
SNX10	metacluster_22.20	MAFG (directAnnotation).
SNX10	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
SNX10	metacluster_22.17	NFE2 (directAnnotation).
SNX10	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
SNX10	metacluster_22.25	NFE2L2 (directAnnotation).
SNX10	metacluster_22.18	BACH2 (inferredBy_Orthology).
SNX10	metacluster_31.7	FOXO1; FOXO3; FOXO6 (directAnnotation).
SNX10	tfdimers__MD00031	MYB; ZEB1 (directAnnotation).
SNX10	transfac_pro__M05897	ZNF561 (directAnnotation).
SNX10	transfac_pro__M05613	ZNF35 (directAnnotation).
SNX10	transfac_pro__M06007	ZNF69 (directAnnotation).
SNX10	kznf__ZNF785_Imbeault2017_OM_MEME	ZNF785 (directAnnotation).
SNX10	cisbp__M02096	ANHX (directAnnotation).
SNX10	transfac_pro__M06070	ZNF732 (directAnnotation).
SNX10	transfac_pro__M05453	ZBTB26 (directAnnotation).
SNX10	swissregulon__hs__ZNF784	ZNF784 (directAnnotation).
SNX10	transfac_pro__M06712	ZNF287 (directAnnotation).
SNX10	metacluster_134.6	FOXF1; FOXG1; ZNF74 (directAnnotation). FOXG1 (inferredBy_Orthology).
SNX10	tfdimers__MD00295	EBF1; STAT6 (directAnnotation).
SNX10	kznf__ZNF445_Imbeault2017_OM_MEME	ZNF445 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."