Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE186960 | Panc1 cell line | Cell line | Pancreatic cancer | Pancreatic ductal adenocarcinoma (PDAC) | Chemotherapy | gemcitabine | NA | Malignant cells | -0.594461 | 0.00e+00 |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | post | Mono/Macro | 0.265504 | 0.00e+00 |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | post | cDCs | 0.57869 | 1.32e-12 |
GSE212217 | patients | Peripheral blood mononuclear cells | Endometrial cancer | Epigenetic MMRd endometrial carcinoma | Immunotherapy | pembrolizumab | post | Mono/Macro | -0.362657 | 0.00e+00 |
GSE212217 | patients | Peripheral blood mononuclear cells | Endometrial cancer | Epigenetic MMRd endometrial carcinoma | Immunotherapy | pembrolizumab | post | Plasma cells | -0.33802 | 3.92e-03 |
GSE212217 | patients | Peripheral blood mononuclear cells | Endometrial cancer | Epigenetic MMRd endometrial carcinoma | Immunotherapy | pembrolizumab | post | cDCs | -0.374265 | 3.40e-18 |
GSE212217 | patients | Peripheral blood mononuclear cells | Endometrial cancer | Epigenetic MMRd endometrial carcinoma | Immunotherapy | pembrolizumab | pre | Mono/Macro | -0.288152 | 0.00e+00 |
GSE212217 | patients | Peripheral blood mononuclear cells | Endometrial cancer | Epigenetic MMRd endometrial carcinoma | Immunotherapy | pembrolizumab | pre | cDCs | -0.497926 | 9.82e-23 |
GSE212217 | patients | Peripheral blood mononuclear cells | Endometrial cancer | Epigenetic MMRd endometrial carcinoma | Immunotherapy | pembrolizumab | pre | pDCs | -0.44926 | 2.61e-07 |
GSE197268_Tisa-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | tisa-cel (CAR-T) | pre | CD4+ T cells | 0.305553 | 8.38e-43 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Malignant cells | 0.538283 | 9.84e-25 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | -0.780651 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
SNHG5 | transfac_pro__M05792 | ZFP2 (directAnnotation). |
SNHG5 | metacluster_198.5 | TCFL5; TCFL5 (directAnnotation). |
SNHG5 | transfac_pro__M05916 | ZNF407 (directAnnotation). |
SNHG5 | transfac_pro__M06500 | ZNF614 (directAnnotation). |
SNHG5 | transfac_pro__M06834 | PEG3 (directAnnotation). |
SNHG5 | taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth | IRF6 (directAnnotation). |
SNHG5 | transfac_pro__M05609 | SALL3 (directAnnotation). |
SNHG5 | tfdimers__MD00146 | ARID3A; EBF1 (directAnnotation). |
SNHG5 | taipale_tf_pairs__TEAD4_SOX6_NNACAATNNNNNNGAATGY_CAP_repr | SOX6; TEAD4 (directAnnotation). |
SNHG5 | jaspar__MA0702.2 | LMX1A (directAnnotation). |
SNHG5 | transfac_pro__M07356 | EPAS1 (directAnnotation). |
SNHG5 | homer__NVCACGTG_NPAS | NPAS2 (inferredBy_Orthology). |
SNHG5 | transfac_pro__M06786 | ZNF646 (directAnnotation). |
SNHG5 | transfac_pro__M06149 | ZNF132 (directAnnotation). |
SNHG5 | transfac_pro__M07043 | HIF1A (directAnnotation). |
SNHG5 | kznf__ZFP90_Imbeault2017_RP_RCADE | ZFP90 (directAnnotation). |
SNHG5 | transfac_pro__M05877 | ZNF467 (inferredBy_Orthology). |
SNHG5 | metacluster_128.2 | BHLHE40; HES1; HES1; HES1; HES1; HES1; HES2; HES5; HES5; HES5; HES7; HES7; HEY1; HEY1; HEY1; HEY1; HEY1; HEY1; HEY2; HEY2; HEY2; HEY2; HEY2; HEY2; HEY2; HIF1A; MGA; MYC; MYCN; SOHLH2 (directAnnotation). BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; HELT; HELT; HES1; HES1; HES1; HES1; HES2; HES2; HES3; HES3; HES4; HES4; HES5; HES5; HES5; HES5; HES5; HES5; HES5; HES5; HES5; HES5; HES6; HES6; HES7; HES7; HES7; HEY1; HEY1; HEY2; HEY2; HEY2; HEY2; HEYL; HEYL; HEYL; HEYL; HEYL; HEYL; HEYL; HEYL; HEYL; HIF1A; MAX; MLX; MNT; TFEC; TFEC (inferredBy_Orthology). |
SNHG5 | transfac_pro__M05561 | HIC2 (inferredBy_Orthology). |
SNHG5 | cisbp__M01738 | BHLHE40 (inferredBy_Orthology). |
SNHG5 | cisbp__M00938 | MAX (directAnnotation). |
SNHG5 | metacluster_19.11 | MTF1 (directAnnotation). |
SNHG5 | hocomoco__ZBT14_HUMAN.H11MO.0.C | ZBTB14 (directAnnotation). |
SNHG5 | transfac_pro__M05451 | ZNF541 (directAnnotation). |
SNHG5 | taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSN_CAP_repr | E2F3; TBX21 (directAnnotation). |
SNHG5 | taipale_tf_pairs__TEAD4_HES7_RCATTCCNNCRCGYGYN_CAP_repr | HES7; TEAD4 (directAnnotation). |
SNHG5 | transfac_pro__M08005 | TCFL5 (inferredBy_Orthology). |
SNHG5 | tfdimers__MD00110 | FOXG1; FOXO1; PITX3 (directAnnotation). |
SNHG5 | jaspar__MA1995.1 | NPAS4 (inferredBy_Orthology). |
SNHG5 | transfac_pro__M01797 | SIRT6 (directAnnotation). |
SNHG5 | cisbp__M01863 | ZNF711 (inferredBy_Orthology). |
SNHG5 | metacluster_178.8 | ZNF366 (directAnnotation). |
SNHG5 | transfac_pro__M06143 | ZNF16 (directAnnotation). |
SNHG5 | jaspar__MA1460.1 | YY1 (inferredBy_Orthology). |
SNHG5 | metacluster_71.1 | ARNT (directAnnotation). |
SNHG5 | transfac_pro__M05628 | ZNF735 (directAnnotation). |
SNHG5 | metacluster_155.7 | KLF8; ZSCAN1; ZSCAN1; ZSCAN4; ZSCAN4; ZSCAN4 (directAnnotation). |
SNHG5 | transfac_pro__M01269 | NR4A2 (directAnnotation). |
SNHG5 | hdpi__MLX | MLX (directAnnotation). |
SNHG5 | taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr | ERF; HES7 (directAnnotation). |
SNHG5 | jaspar__MA1509.1 | IRF6 (directAnnotation). |
SNHG5 | taipale_tf_pairs__ALX4_EOMES_NGYGYTAAYNNNNNNTNACACNN_CAP | ALX4; EOMES (directAnnotation). |
SNHG5 | metacluster_13.3 | ARNTL; ARNTL; ARNTL; ARNTL2; ASCL1; BHLHE40; BHLHE40; BHLHE41; CLOCK; CLOCK; HAND1; HAND2; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MAX; MITF; MITF; MITF; MNT; MNT; MXD1; MXD3; MXD4; MXD4; MXI1; MXI1; MXI1; MXI1; MXI1; MYC; MYC; MYC; MYC; MYC; MYC; MYC; MYC; MYC; MYC; MYC; MYC; MYCN; MYCN; MYCN; MYCN; MYF5; MYF6; MYOD1; MYOG; NHLH1; NPAS2; NPAS2; TAL1; TAL2; TCF12; TCF3; TCF4; TFE3; TFE3; TFE3; TFEB; TFEB; TFEC; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2 (directAnnotation). ARNTL; CLOCK; CLOCK; MAX; MAX; MAX; MAX; MAX; MYC; MYC; MYC; MYC; NPAS2; USF2 (inferredBy_Orthology). |
SNHG5 | transfac_pro__M06312 | ZNF79 (directAnnotation). |
SNHG5 | transfac_pro__M02012 | HIF1A (directAnnotation). |
SNHG5 | jaspar__MA1106.1 | HIF1A (directAnnotation). |
SNHG5 | nitta__Ets98B_TTCTAG20NTA_KI_TAMCGGATGC_m2_c4 | SPDEF (inferredBy_Orthology). |
SNHG5 | metacluster_10.18 | MAX (directAnnotation). |
SNHG5 | taipale_tf_pairs__HOXB2_ETV7_NSCGGAARNNNNNMATTAN_CAP_repr | ETV7; HOXB2 (directAnnotation). |
SNHG5 | transfac_pro__M05567 | OVOL1 (inferredBy_Orthology). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |