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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SH3KBP1

Summary for SH3KBP1

Gene information	Gene symbol	SH3KBP1
	Ensembl ID	ENSG00000147010
	Entrez ID	30011
	Gene name	SH3 domain containing kinase binding protein 1
	Synonyms	CIN85
	Gene type	protein_coding
	UniProtAcc	Q96B97

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Dataset with differentially expressed gene: SH3KBP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.36254	1.70e-15
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.76048	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.30241	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.298997	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.25991	8.62e-12
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	-0.286542	1.85e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.295481	6.65e-06
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.299638	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.951563	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.256512	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.615046	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.884341	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.492088	6.09e-25
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.555337	3.25e-24
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.621439	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.546373	0.00e+00

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Expression of SH3KBP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SH3KBP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SH3KBP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SH3KBP1	hsa-miR-4757-5p	98.6449	NM_001024666
SH3KBP1	hsa-miR-6744-3p	98.6449	NM_001024666
SH3KBP1	hsa-miR-6809-3p	98.4918	NM_001184960
SH3KBP1	hsa-miR-4753-3p	98.2049	NM_001184960
SH3KBP1	hsa-miR-335-3p	97.9557	NM_001024666
SH3KBP1	hsa-miR-448	97.0072	NM_001024666
SH3KBP1	hsa-miR-96-5p	96.9482	NM_001024666
SH3KBP1	hsa-miR-548p	96.365	NM_001024666
SH3KBP1	hsa-miR-12133	96.2072	NM_001024666
SH3KBP1	hsa-miR-1271-5p	96.2072	NM_001024666
SH3KBP1	hsa-miR-539-5p	95.5771	NM_001024666
SH3KBP1	hsa-miR-7112-3p	94.6872	NM_001184960
SH3KBP1	hsa-miR-10527-5p	94.6306	NM_001024666
SH3KBP1	hsa-miR-4504	94.5216	NM_001024666
SH3KBP1	hsa-miR-520d-5p	94.0513	NM_001024666
SH3KBP1	hsa-miR-524-5p	94.0513	NM_001024666
SH3KBP1	hsa-miR-4775	93.7701	NM_001184960
SH3KBP1	hsa-miR-340-5p	93.494	NM_001184960
SH3KBP1	hsa-miR-8066	93.2759	NM_001184960
SH3KBP1	hsa-miR-8087	93.0978	NM_001184960
SH3KBP1	hsa-miR-1252-3p	92.9144	NM_001184960
SH3KBP1	hsa-miR-6885-3p	92.6859	NM_001184960
SH3KBP1	hsa-miR-4483	92.0912	NM_001184960
SH3KBP1	hsa-miR-182-5p	91.9409	NM_001024666
SH3KBP1	hsa-miR-1207-5p	91.8827	NM_001184960
SH3KBP1	hsa-miR-624-5p	91.7819	NM_001024666
SH3KBP1	hsa-miR-548c-3p	91.1239	NM_001024666
SH3KBP1	hsa-miR-585-5p	91.1015	NM_001024666
SH3KBP1	hsa-miR-4763-3p	90.8921	NM_001184960
SH3KBP1	hsa-miR-4279	90.7952	NM_001184960
SH3KBP1	hsa-miR-218-5p	90.7137	NM_001024666
SH3KBP1	hsa-miR-5700	90.519	NM_001024666
SH3KBP1	hsa-miR-548aj-5p	90.4551	NM_001024666
SH3KBP1	hsa-miR-548g-5p	90.4551	NM_001024666
SH3KBP1	hsa-miR-548x-5p	90.4551	NM_001024666
SH3KBP1	hsa-miR-548f-5p	90.4551	NM_001024666
SH3KBP1	hsa-miR-486-3p	89.3699	NM_001184960
SH3KBP1	hsa-miR-6842-3p	87.8153	NM_001024666
SH3KBP1	hsa-miR-1293	87.4335	NM_001184960
SH3KBP1	hsa-miR-432-3p	87.0845	NM_001184960
SH3KBP1	hsa-miR-548av-3p	87.0793	NM_001184960
SH3KBP1	hsa-miR-4282	86.8231	NM_001184960
SH3KBP1	hsa-miR-211-3p	86.5796	NM_001184960
SH3KBP1	hsa-miR-4505	86.5136	NM_001024666
SH3KBP1	hsa-miR-5787	86.5136	NM_001024666
SH3KBP1	hsa-miR-4470	86.3955	NM_001024666
SH3KBP1	hsa-miR-542-3p	86.173	NM_001024666
SH3KBP1	hsa-miR-513a-3p	86.0864	NM_001184960
SH3KBP1	hsa-miR-3606-3p	86.0864	NM_001184960
SH3KBP1	hsa-miR-513c-3p	86.0864	NM_001184960

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Motifs and transcription factors (TFs) regulating SH3KBP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SH3KBP1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SH3KBP1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
SH3KBP1	transfac_pro__M01303	SP1 (directAnnotation).
SH3KBP1	taipale_tf_pairs__MYBL1_ELF1_NMCCGGAACCGTTR_CAP_repr	ELF1; MYBL1 (directAnnotation).
SH3KBP1	metacluster_144.10	ZNF100 (directAnnotation).
SH3KBP1	transfac_pro__M01299	MECP2 (directAnnotation).
SH3KBP1	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
SH3KBP1	kznf__ZNF716_Imbeault2017_RP_RCADE	ZNF716 (directAnnotation).
SH3KBP1	metacluster_131.3	ZNF436 (inferredBy_Orthology).
SH3KBP1	metacluster_76.1	ZNF345; ZNF345 (directAnnotation). MYB; MYBL1 (inferredBy_Orthology).
SH3KBP1	transfac_pro__M06756	ZNF646 (directAnnotation).
SH3KBP1	transfac_pro__M05465	SNAI3 (inferredBy_Orthology).
SH3KBP1	transfac_pro__M06989	ZNF236 (directAnnotation).
SH3KBP1	transfac_pro__M04944	GABPA (directAnnotation).
SH3KBP1	transfac_pro__M06487	ZNF695 (directAnnotation).
SH3KBP1	transfac_pro__M05609	SALL3 (directAnnotation).
SH3KBP1	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
SH3KBP1	tfdimers__MD00303	ETS2; OTX1; OTX2 (directAnnotation).
SH3KBP1	swissregulon__hs__ZBTB7A	ZBTB7A (directAnnotation).
SH3KBP1	transfac_pro__M05421	MYNN (inferredBy_Orthology).
SH3KBP1	transfac_pro__M05915	ZBTB20 (directAnnotation).
SH3KBP1	transfac_pro__M04937	TCF12 (directAnnotation).
SH3KBP1	transfac_pro__M05524	ZNF362 (directAnnotation).
SH3KBP1	tfdimers__MD00010	TP53; TP63; TP73 (directAnnotation).
SH3KBP1	metacluster_182.5	HINFP (directAnnotation).
SH3KBP1	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
SH3KBP1	metacluster_7.6	ZBTB11 (directAnnotation).
SH3KBP1	transfac_pro__M06172	ZNF90 (directAnnotation).
SH3KBP1	jaspar__MA1489.1	FOXN3 (directAnnotation).
SH3KBP1	metacluster_26.3	ZNF232 (directAnnotation).
SH3KBP1	transfac_pro__M12556	ETV4 (directAnnotation).
SH3KBP1	metacluster_80.6	ZIC4 (directAnnotation).
SH3KBP1	metacluster_80.4	ZIC3 (directAnnotation).
SH3KBP1	kznf__ZNF445_Imbeault2017_OM_MEME	ZNF445 (directAnnotation).
SH3KBP1	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
SH3KBP1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
SH3KBP1	transfac_pro__M00655	ETV4 (directAnnotation).
SH3KBP1	transfac_pro__M03844	ELK4 (directAnnotation).
SH3KBP1	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
SH3KBP1	taipale_tf_pairs__TEAD4_CEBPD_NTTRCGYAANNNNNNRGWATGY_CAP	CEBPD; TEAD4 (directAnnotation).
SH3KBP1	jaspar__MA1509.1	IRF6 (directAnnotation).
SH3KBP1	metacluster_187.2	PRDM1; PRDM1; ZNF184 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."