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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SGK1

Summary for SGK1

Gene information	Gene symbol	SGK1
	Ensembl ID	ENSG00000118515
	Entrez ID	6446
	Gene name	serum/glucocorticoid regulated kinase 1
	Synonyms	SGK
	Gene type	protein_coding
	UniProtAcc	O00141

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Dataset with differentially expressed gene: SGK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.420529	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.579428	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.463561	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.288252	2.54e-12
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.383804	4.62e-07
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.343008	1.97e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.253822	2.63e-05
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.422244	9.59e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.738152	3.28e-41
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.339645	4.77e-09
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	-0.374591	2.87e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.915902	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.502619	5.87e-36
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Mono/Macro	-0.351675	7.81e-18
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	cDCs	-0.605971	1.05e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.65184	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.678798	0.00e+00

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Expression of SGK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SGK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SGK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SGK1	hsa-miR-323a-3p	99.7877	NM_001143676
SGK1	hsa-miR-548aw	99.2464	NM_001143676
SGK1	hsa-miR-4533	98.8096	NM_001143678
SGK1	hsa-miR-19a-3p	98.1206	NM_001143676
SGK1	hsa-miR-19b-3p	98.1206	NM_001143676
SGK1	hsa-miR-101-3p	96.9483	NM_001143676
SGK1	hsa-miR-365a-3p	96.616	NM_001143676
SGK1	hsa-miR-365b-3p	96.616	NM_001143676
SGK1	hsa-miR-200b-5p	95.3476	NM_001143676
SGK1	hsa-miR-200a-5p	95.3476	NM_001143676
SGK1	hsa-miR-506-3p	94.2668	NM_001143676
SGK1	hsa-miR-124-3p	94.2668	NM_001143676
SGK1	hsa-miR-141-5p	93.9324	NM_001143678
SGK1	hsa-miR-3160-5p	93.8904	NM_001143678
SGK1	hsa-miR-6715a-3p	93.6561	NM_001143676
SGK1	hsa-miR-3613-3p	93.3254	NM_001143676
SGK1	hsa-miR-29c-3p	92.664	NM_001143676
SGK1	hsa-miR-29a-3p	92.664	NM_001143676
SGK1	hsa-miR-29b-3p	92.664	NM_001143676
SGK1	hsa-miR-4666a-3p	92.0934	NM_001143676
SGK1	hsa-miR-4668-3p	91.8973	NM_001143678
SGK1	hsa-miR-299-5p	91.3171	NM_001143678
SGK1	hsa-miR-4696	89.9157	NM_001143676
SGK1	hsa-miR-5582-5p	89.8511	NM_001143676
SGK1	hsa-miR-15b-5p	89.2927	NM_001143676
SGK1	hsa-miR-16-5p	89.2927	NM_001143676
SGK1	hsa-miR-15a-5p	89.2927	NM_001143676
SGK1	hsa-miR-195-5p	89.2927	NM_001143676
SGK1	hsa-miR-10399-5p	89.2846	NM_001143676
SGK1	hsa-miR-6504-3p	89.2846	NM_001143676
SGK1	hsa-miR-3121-3p	88.4685	NM_001143676
SGK1	hsa-miR-5682	87.4737	NM_001143676
SGK1	hsa-miR-497-5p	86.1275	NM_001143676
SGK1	hsa-miR-6838-5p	86.1275	NM_001143676
SGK1	hsa-miR-424-5p	86.1275	NM_001143676
SGK1	hsa-miR-338-5p	85.7464	NM_001143676
SGK1	hsa-let-7g-3p	85.7412	NM_001143676
SGK1	hsa-let-7a-2-3p	85.7412	NM_001143676
SGK1	hsa-miR-518a-5p	85.6081	NM_001143676
SGK1	hsa-miR-527	85.6081	NM_001143676
SGK1	hsa-miR-133b	85.3598	NM_001143678
SGK1	hsa-miR-133a-3p	85.3598	NM_001143678
SGK1	hsa-miR-552-3p	84.9077	NM_001143676
SGK1	hsa-miR-4799-5p	84.3015	NM_001143678
SGK1	hsa-miR-520d-5p	84.0608	NM_001143676
SGK1	hsa-miR-524-5p	84.0608	NM_001143676
SGK1	hsa-miR-6818-5p	83.6569	NM_001143676
SGK1	hsa-miR-4789-3p	83.4627	NM_001143678
SGK1	hsa-miR-95-5p	83.3894	NM_001143678
SGK1	hsa-miR-329-5p	83.2371	NM_001143678

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Motifs and transcription factors (TFs) regulating SGK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SGK1	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
SGK1	cisbp__M00262	ARX (directAnnotation).
SGK1	transfac_pro__M01182	HINFP (directAnnotation).
SGK1	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
SGK1	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).
SGK1	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
SGK1	cisbp__M04023	CREB1 (directAnnotation).
SGK1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
SGK1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
SGK1	taipale_tf_pairs__FOXJ2_HOXB13_TTTWATNRNMAACA_CAP_repr	FOXJ2; HOXB13 (directAnnotation).
SGK1	cisbp__M01815	CEBPE (inferredBy_Orthology).
SGK1	transfac_pro__M06943	PBX3 (directAnnotation).
SGK1	transfac_pro__M05759	ZNF544 (directAnnotation).
SGK1	metacluster_47.1	E4F1; SPDEF; SPDEF (directAnnotation).
SGK1	transfac_pro__M06410	ZNF497 (directAnnotation).
SGK1	taipale_tf_pairs__GCM2_TEF_RTRCGGGNNNNTTACGTAA_CAP_repr	GCM2; TEF (directAnnotation).
SGK1	metacluster_134.1	ZFP69 (directAnnotation).
SGK1	swissregulon__mm__Sox5	SOX5 (inferredBy_Orthology).
SGK1	transfac_pro__M02830	ZSCAN26 (inferredBy_Orthology).
SGK1	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
SGK1	taipale_cyt_meth__CREB1_NRTGAYGCGTN_eDBD_meth_repr	CREB1 (directAnnotation).
SGK1	transfac_pro__M05707	ZNF239 (inferredBy_Orthology).
SGK1	transfac_public__M00285	NFE2L1 (directAnnotation).
SGK1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
SGK1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
SGK1	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).
SGK1	cisbp__M00809	PRDM11 (inferredBy_Orthology).
SGK1	transfac_pro__M06550	ZNF519 (directAnnotation).
SGK1	metacluster_22.32	NFE2L2 (directAnnotation).
SGK1	metacluster_22.25	NFE2L2 (directAnnotation).
SGK1	metacluster_22.28	BACH1 (directAnnotation).
SGK1	metacluster_22.19	NFE2 (directAnnotation).
SGK1	metacluster_22.29	NFE2 (directAnnotation).
SGK1	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
SGK1	hocomoco__PDX1_MOUSE.H11MO.0.B	PDX1 (inferredBy_Orthology).
SGK1	metacluster_22.17	NFE2 (directAnnotation).
SGK1	taipale_tf_pairs__HOXA4_RTMATTAN_HT	HOXA4 (directAnnotation).
SGK1	taipale_tf_pairs__GCM2_PITX1_RTRCGGGSGATTAN_CAP_repr	GCM2; PITX1 (directAnnotation).
SGK1	transfac_pro__M04950	EGR1 (directAnnotation).
SGK1	transfac_pro__M01249	EPAS1 (directAnnotation).
SGK1	transfac_pro__M04913	ZBTB7A (directAnnotation).
SGK1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
SGK1	taipale__MYBL2_DBD_AACCGTTAACGGNN	MYBL2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SGK1	"4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid"	DB08191	small molecule
SGK1	"Flavin mononucleotide"	DB03247	small molecule
SGK1	"[4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid"	DB07837	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."