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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SETD5

Summary for SETD5

Gene information	Gene symbol	SETD5
	Ensembl ID	ENSG00000168137
	Entrez ID	55209
	Gene name	SET domain containing 5
	Synonyms	FLJ10707\|SETD5A
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SETD5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.272973	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.301769	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.285129	8.51e-35
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.438835	1.44e-38

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Expression of SETD5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SETD5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SETD5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SETD5	hsa-miR-6728-3p	98.3791	NM_001080517
SETD5	hsa-miR-30e-5p	97.8173	NM_001080517
SETD5	hsa-miR-144-3p	97.4586	NM_001080517
SETD5	hsa-miR-30d-5p	97.1934	NM_001080517
SETD5	hsa-miR-30b-5p	97.1934	NM_001080517
SETD5	hsa-miR-30c-5p	97.1934	NM_001080517
SETD5	hsa-miR-30a-5p	97.1934	NM_001080517
SETD5	hsa-miR-4704-3p	95.5743	NM_001080517
SETD5	hsa-miR-410-5p	95.1974	NM_001292043
SETD5	hsa-miR-323b-5p	94.9605	NM_001292043
SETD5	hsa-miR-494-5p	94.9605	NM_001292043
SETD5	hsa-miR-584-5p	94.3301	NM_001292043
SETD5	hsa-miR-132-3p	93.6531	NM_001080517
SETD5	hsa-miR-212-3p	93.6531	NM_001080517
SETD5	hsa-miR-577	93.0075	NM_001292043
SETD5	hsa-miR-4673	92.5425	NM_001080517
SETD5	hsa-miR-4645-5p	92.5425	NM_001080517
SETD5	hsa-miR-4437	92.2268	NM_001292043
SETD5	hsa-miR-194-5p	91.9336	NM_001080517
SETD5	hsa-miR-320e	91.0833	NM_001080517
SETD5	hsa-miR-10399-5p	90.5221	NM_001292043
SETD5	hsa-miR-6504-3p	90.5221	NM_001292043
SETD5	hsa-miR-27b-3p	89.7795	NM_001080517
SETD5	hsa-miR-9985	89.7795	NM_001080517
SETD5	hsa-miR-27a-3p	89.7795	NM_001080517
SETD5	hsa-miR-3622b-3p	89.1104	NM_001080517
SETD5	hsa-miR-3622a-3p	89.1104	NM_001080517
SETD5	hsa-miR-758-5p	88.8983	NM_001080517
SETD5	hsa-miR-196a-1-3p	88.5403	NM_001292043
SETD5	hsa-miR-545-5p	88.2087	NM_001080517
SETD5	hsa-miR-6826-3p	87.5846	NM_001080517
SETD5	hsa-miR-4731-5p	87.1509	NM_001292043
SETD5	hsa-miR-5692c	87.0064	NM_001292043
SETD5	hsa-miR-5692b	87.0064	NM_001292043
SETD5	hsa-miR-4325	86.6113	NM_001080517
SETD5	hsa-miR-8057	86.6086	NM_001292043
SETD5	hsa-miR-1912-5p	86.3734	NM_001080517
SETD5	hsa-miR-4533	85.6241	NM_001292043
SETD5	hsa-miR-548as-3p	85.4621	NM_001292043
SETD5	hsa-miR-3529-3p	85.4213	NM_001292043
SETD5	hsa-miR-3175	85.0572	NM_001292043
SETD5	hsa-miR-6796-5p	84.7588	NM_001292043
SETD5	hsa-miR-646	84.7147	NM_001080517
SETD5	hsa-miR-652-5p	84.2145	NM_001080517
SETD5	hsa-miR-519c-3p	84.0881	NM_001292043
SETD5	hsa-miR-519a-3p	84.0881	NM_001292043
SETD5	hsa-miR-519b-3p	84.0881	NM_001292043
SETD5	hsa-miR-4310	83.9966	NM_001292043
SETD5	hsa-miR-4494	82.9132	NM_001080517
SETD5	hsa-miR-7157-5p	82.2862	NM_001292043

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Motifs and transcription factors (TFs) regulating SETD5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SETD5	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
SETD5	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SETD5	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SETD5	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."