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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SAR1A

Summary for SAR1A

Gene information	Gene symbol	SAR1A
	Ensembl ID	ENSG00000079332
	Entrez ID	56681
	Gene name	secretion associated Ras related GTPase 1A
	Synonyms	SAR1\|Sara\|SARA1
	Gene type	protein_coding
	UniProtAcc	Q9NR31

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Dataset with differentially expressed gene: SAR1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.829814	6.96e-13
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.270435	2.11e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.383646	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.301362	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.650277	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.438982	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.263284	3.39e-07
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.318079	3.19e-07
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.463542	1.54e-44
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.480432	0.00e+00

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Expression of SAR1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SAR1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SAR1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SAR1A	hsa-miR-4531	98.049	NM_001142648
SAR1A	hsa-miR-5189-5p	95.2482	NM_001142648
SAR1A	hsa-miR-3187-5p	95.2482	NM_001142648
SAR1A	hsa-miR-612	95.2482	NM_001142648
SAR1A	hsa-miR-6860	95.2482	NM_001142648
SAR1A	hsa-miR-1285-3p	95.2482	NM_001142648
SAR1A	hsa-miR-1206	94.6277	NM_001142648
SAR1A	hsa-miR-6853-3p	94.4145	NM_001142648
SAR1A	hsa-miR-4516	93.6276	NM_001142648
SAR1A	hsa-miR-34c-5p	91.9632	NM_001142648
SAR1A	hsa-miR-449b-5p	91.9632	NM_001142648
SAR1A	hsa-miR-449a	90.4986	NM_001142648
SAR1A	hsa-miR-34a-5p	90.4986	NM_001142648
SAR1A	hsa-miR-455-3p	90.2551	NM_001142648
SAR1A	hsa-miR-525-5p	89.5803	NM_001142648
SAR1A	hsa-miR-520a-5p	89.5803	NM_001142648
SAR1A	hsa-miR-4434	89.1652	NM_001142648
SAR1A	hsa-miR-5703	89.1652	NM_001142648
SAR1A	hsa-miR-4779	88.7081	NM_001142648
SAR1A	hsa-miR-7845-5p	88.4427	NM_001142648
SAR1A	hsa-miR-3925-3p	88.3835	NM_001142648
SAR1A	hsa-miR-196a-1-3p	88.3315	NM_001142648
SAR1A	hsa-miR-6824-5p	88.0164	NM_001142648
SAR1A	hsa-miR-6783-5p	87.4646	NM_001142648
SAR1A	hsa-miR-12124	87.2768	NM_001142648
SAR1A	hsa-miR-548e-5p	86.6148	NM_001142648
SAR1A	hsa-miR-4776-5p	84.5115	NM_001142648
SAR1A	hsa-miR-3919	84.2687	NM_001142648
SAR1A	hsa-miR-198	84.1509	NM_001142648
SAR1A	hsa-miR-590-3p	83.5811	NM_001142648
SAR1A	hsa-miR-513a-3p	83.5398	NM_001142648
SAR1A	hsa-miR-513c-3p	83.5398	NM_001142648
SAR1A	hsa-miR-6815-3p	83.0582	NM_001142648
SAR1A	hsa-miR-12136	82.0776	NM_001142648
SAR1A	hsa-miR-548ax	82.0461	NM_001142648
SAR1A	hsa-miR-548ao-5p	82.0461	NM_001142648
SAR1A	hsa-miR-3606-3p	81.0182	NM_001142648
SAR1A	hsa-miR-544a	80.4941	NM_001142648
SAR1A	hsa-miR-4306	80.1855	NM_001142648

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Motifs and transcription factors (TFs) regulating SAR1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SAR1A	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
SAR1A	swissregulon__hs__ELF2	ELF2 (directAnnotation).
SAR1A	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SAR1A	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
SAR1A	cisbp__M08198	ELF1 (directAnnotation).
SAR1A	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
SAR1A	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SAR1A	swissregulon__hs__ELK1	ELK1 (directAnnotation).
SAR1A	metacluster_183.4	ETS1 (inferredBy_Orthology).
SAR1A	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
SAR1A	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
SAR1A	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
SAR1A	jaspar__MA1483.2	ELF2 (directAnnotation).
SAR1A	transfac_pro__M01299	MECP2 (directAnnotation).
SAR1A	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
SAR1A	jaspar__MA1708.1	ETV7 (directAnnotation).
SAR1A	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
SAR1A	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SAR1A	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
SAR1A	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
SAR1A	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."