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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RIPK2

Summary for RIPK2

Gene information	Gene symbol	RIPK2
	Ensembl ID	ENSG00000104312
	Entrez ID	8767
	Gene name	receptor interacting serine/threonine kinase 2
	Synonyms	CARD3\|CARDIAK\|RICK\|RIP2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RIPK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.986714	8.19e-07
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.280077	5.32e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.524502	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.442152	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.349722	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.657126	1.63e-18

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Expression of RIPK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RIPK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RIPK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RIPK2	hsa-miR-501-5p	98.3681	NM_003821
RIPK2	hsa-miR-6769a-5p	92.7253	NM_003821
RIPK2	hsa-miR-4659a-3p	91.5201	NM_003821
RIPK2	hsa-miR-4659b-3p	91.5201	NM_003821
RIPK2	hsa-miR-153-5p	91.5128	NM_003821
RIPK2	hsa-miR-6769b-5p	91.0445	NM_003821
RIPK2	hsa-miR-5582-3p	88.9254	NM_003821
RIPK2	hsa-miR-4756-3p	87.4266	NM_003821
RIPK2	hsa-miR-6782-3p	87.0523	NM_003821
RIPK2	hsa-miR-200c-3p	86.6713	NM_003821
RIPK2	hsa-miR-429	86.6713	NM_003821
RIPK2	hsa-miR-200b-3p	86.6713	NM_003821
RIPK2	hsa-miR-330-3p	82.1235	NM_003821

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Motifs and transcription factors (TFs) regulating RIPK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RIPK2	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
RIPK2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RIPK2	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
RIPK2	metacluster_144.13	HIC1; HIC1 (directAnnotation).
RIPK2	transfac_pro__M00514	ATF4 (directAnnotation).
RIPK2	transfac_pro__M00665	SP3 (directAnnotation).
RIPK2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RIPK2	transfac_pro__M02898	SMAD3 (directAnnotation).
RIPK2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
RIPK2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
RIPK2	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
RIPK2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
RIPK2	transfac_pro__M07329	SP7 (directAnnotation).
RIPK2	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
RIPK2	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
RIPK2	tfdimers__MD00297	POU5F1; ZEB1 (directAnnotation).
RIPK2	transfac_pro__M01239	RELA (directAnnotation).
RIPK2	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RIPK2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."