Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RICTOR

Summary for RICTOR

Gene information	Gene symbol	RICTOR
	Ensembl ID	ENSG00000164327
	Entrez ID	253260
	Gene name	RPTOR independent companion of MTOR complex 2
	Synonyms	AVO3\|KIAA1999\|MGC39830\|PIA
	Gene type	protein_coding
	UniProtAcc	Q6R327

Top

Dataset with differentially expressed gene: RICTOR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.08744	3.54e-09
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.496513	3.18e-23
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.308315	7.49e-28
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.527458	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.368483	6.10e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.541535	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.383503	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.335198	1.48e-06
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.365208	1.53e-36

Top

Expression of RICTOR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to RICTOR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RICTOR	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating RICTOR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RICTOR	hsa-miR-4789-5p	99.9776	NM_001285439
RICTOR	hsa-let-7a-3p	99.971	NM_001285439
RICTOR	hsa-miR-98-3p	99.971	NM_001285439
RICTOR	hsa-let-7f-1-3p	99.971	NM_001285439
RICTOR	hsa-let-7b-3p	99.971	NM_001285439
RICTOR	hsa-miR-548c-3p	99.7005	NM_001285439
RICTOR	hsa-miR-4276	99.5583	NM_001285439
RICTOR	hsa-miR-142-3p	99.2991	NM_001285439
RICTOR	hsa-miR-4666a-3p	99.284	NM_001285439
RICTOR	hsa-miR-1185-1-3p	98.9256	NM_001285439
RICTOR	hsa-let-7f-2-3p	98.9256	NM_001285439
RICTOR	hsa-miR-1185-2-3p	98.9256	NM_001285439
RICTOR	hsa-miR-12124	98.8655	NM_001285439
RICTOR	hsa-miR-3188	98.577	NM_001285439
RICTOR	hsa-miR-3662	98.5635	NM_001285440
RICTOR	hsa-miR-659-3p	98.5461	NM_001285439
RICTOR	hsa-miR-19b-3p	98.1562	NM_001285439
RICTOR	hsa-miR-19a-3p	98.1562	NM_001285439
RICTOR	hsa-miR-4668-5p	97.9206	NM_001285439
RICTOR	hsa-miR-3680-3p	97.8941	NM_001285439
RICTOR	hsa-miR-5011-5p	97.8376	NM_001285440
RICTOR	hsa-miR-381-3p	96.7851	NM_001285439
RICTOR	hsa-miR-300	96.7851	NM_001285439
RICTOR	hsa-miR-448	96.7827	NM_001285439
RICTOR	hsa-miR-6733-5p	96.7304	NM_001285439
RICTOR	hsa-miR-6739-5p	96.7304	NM_001285439
RICTOR	hsa-miR-4482-3p	96.6257	NM_001285439
RICTOR	hsa-miR-5002-5p	96.3427	NM_001285439
RICTOR	hsa-miR-3161	96.1009	NM_001285440
RICTOR	hsa-miR-3646	96.0968	NM_001285440
RICTOR	hsa-miR-3613-3p	96.0017	NM_001285439
RICTOR	hsa-miR-6760-3p	95.7983	NM_001285440
RICTOR	hsa-miR-3153	95.7093	NM_001285439
RICTOR	hsa-miR-548an	95.4536	NM_001285439
RICTOR	hsa-miR-3065-5p	94.9932	NM_001285439
RICTOR	hsa-miR-323a-3p	94.9555	NM_001285440
RICTOR	hsa-miR-3973	94.7914	NM_001285440
RICTOR	hsa-miR-4677-3p	94.7189	NM_001285440
RICTOR	hsa-miR-218-5p	94.6922	NM_001285439
RICTOR	hsa-miR-4719	94.3368	NM_001285440
RICTOR	hsa-miR-342-3p	94.174	NM_001285440
RICTOR	hsa-miR-636	93.9818	NM_001285439
RICTOR	hsa-miR-582-5p	93.6859	NM_001285439
RICTOR	hsa-miR-96-5p	93.5479	NM_001285439
RICTOR	hsa-miR-12133	93.4461	NM_001285439
RICTOR	hsa-miR-1271-5p	93.4461	NM_001285439
RICTOR	hsa-miR-7159-3p	93.3463	NM_001285439
RICTOR	hsa-miR-5688	93.1342	NM_001285439
RICTOR	hsa-miR-1305	92.9704	NM_001285440
RICTOR	hsa-miR-7151-5p	92.7577	NM_001285440

Page: 1 2 3 4

Top

Motifs and transcription factors (TFs) regulating RICTOR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RICTOR	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RICTOR	cisbp__M00788	ZFY (inferredBy_Orthology).
RICTOR	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RICTOR	metacluster_175.1	ZNF283 (directAnnotation).
RICTOR	hdpi__ZNF304	ZNF304 (directAnnotation).
RICTOR	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RICTOR	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RICTOR	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RICTOR	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RICTOR	transfac_pro__M03806	ZBTB7C (directAnnotation).
RICTOR	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RICTOR	transfac_pro__M02913	SP140 (inferredBy_Orthology).
RICTOR	jaspar__MA0748.2	YY2 (directAnnotation).
RICTOR	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RICTOR	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RICTOR	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RICTOR	transfac_pro__M00430	E2F1 (directAnnotation).
RICTOR	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RICTOR	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
RICTOR	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
RICTOR	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
RICTOR	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RICTOR	hdpi__TIMELESS	TIMELESS (directAnnotation).
RICTOR	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RICTOR	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
RICTOR	metacluster_191.5	SPDEF (inferredBy_Orthology).
RICTOR	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RICTOR	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
RICTOR	hdpi__RARA	RARA (directAnnotation).
RICTOR	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RICTOR	hdpi__ELF2	ELF2 (directAnnotation).
RICTOR	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
RICTOR	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
RICTOR	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RICTOR	jaspar__MA1583.1	ZFP57 (directAnnotation).
RICTOR	transfac_pro__M02898	SMAD3 (directAnnotation).
RICTOR	hdpi__HTATIP2	HTATIP2 (directAnnotation).
RICTOR	jaspar__MA1721.1	ZNF93 (directAnnotation).
RICTOR	transfac_pro__M04916	TAF1 (directAnnotation).
RICTOR	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RICTOR	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
RICTOR	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RICTOR	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RICTOR	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
RICTOR	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
RICTOR	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RICTOR	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
RICTOR	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
RICTOR	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
RICTOR	tfdimers__MD00364	WT1 (directAnnotation).

Page: 1 2 3 4

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."