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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: RCAN3

Summary for RCAN3

Gene informationGene symbol

RCAN3

Ensembl ID

ENSG00000117602

Entrez ID

11123

Gene nameRCAN family member 3
SynonymsDSCR1L2
Gene typeprotein_coding
UniProtAcc

Q9UKA8


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Dataset with differentially expressed gene: RCAN3

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD4+ T cells0.287610.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD8+ T cells0.3760510.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells0.2784910.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreCD8+ T cells0.3645619.62e-12

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells-0.3887910.00e+00

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Expression of RCAN3 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to RCAN3

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RCAN3

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
RCAN3hsa-miR-224-3p95.0757NM_001251985
RCAN3hsa-miR-522-3p95.0757NM_001251985
RCAN3hsa-miR-4760-3p92.8237NM_001251979
RCAN3hsa-miR-2114-5p86.6144NM_001251985
RCAN3hsa-miR-6507-3p85.738NM_001251985
RCAN3hsa-miR-7159-5p85.3974NM_001251979
RCAN3hsa-miR-589-5p84.4485NM_001251979
RCAN3hsa-miR-5196-3p84.302NM_001251979
RCAN3hsa-miR-130583.2692NM_001251979
RCAN3hsa-miR-1226-5p82.994NM_001251979
RCAN3hsa-miR-513c-3p81.8241NM_001251979
RCAN3hsa-miR-513a-3p81.8241NM_001251979
RCAN3hsa-miR-4778-5p81.7342NM_001251979
RCAN3hsa-miR-7159-3p81.1305NM_001251979
RCAN3hsa-miR-3606-3p80.7452NM_001251979
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Motifs and transcription factors (TFs) regulating RCAN3

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
RCAN3kznf__ZNF311_Imbeault2017_RP_ChIP-seqZNF311 (directAnnotation).
RCAN3tfdimers__MD00364WT1 (directAnnotation).
RCAN3hdpi__GTF3C2GTF3C2 (directAnnotation).
RCAN3metacluster_198.3ZFP64 (directAnnotation).
RCAN3jaspar__MA1721.1ZNF93 (directAnnotation).
RCAN3transfac_pro__M08005TCFL5 (inferredBy_Orthology).
RCAN3kznf__ZNF548_Imbeault2017_OM_RCADEZNF548 (directAnnotation).
RCAN3metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RCAN3swissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
RCAN3hocomoco__EGR4_HUMAN.H11MO.0.DEGR4 (directAnnotation).
RCAN3kznf__ZNF571_Imbeault2017_OM_RCADEZNF571 (directAnnotation).
RCAN3transfac_pro__M03876ZBTB33 (directAnnotation).
RCAN3transfac_pro__M04646FOXN4 (directAnnotation).
RCAN3metacluster_126.2ZBTB4; ZBTB4 (directAnnotation).
RCAN3kznf__ZBTB14_Schmitges2016_RCADEZBTB14 (directAnnotation).
RCAN3kznf__ZNF2_Imbeault2017_OM_RCADEZNF2 (directAnnotation).
RCAN3kznf__ZNF383_Imbeault2017_OM_RCADEZNF383 (directAnnotation).
RCAN3taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
RCAN3transfac_pro__M07329SP7 (directAnnotation).
RCAN3transfac_pro__M04617ZBTB7A (directAnnotation).
RCAN3transfac_pro__M07436WT1 (directAnnotation).
RCAN3transfac_pro__M01858TFAP2B (directAnnotation).
RCAN3metacluster_66.4ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."