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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAP1A

Summary for RAP1A

Gene information	Gene symbol	RAP1A
	Ensembl ID	ENSG00000116473
	Entrez ID	5906
	Gene name	RAP1A, member of RAS oncogene family
	Synonyms	KREV-1\|SMGP21
	Gene type	protein_coding
	UniProtAcc	P62834

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Dataset with differentially expressed gene: RAP1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.275866	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.410195	3.16e-10
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.555127	1.34e-02
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.714855	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.292724	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.25527	1.32e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.564686	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.253053	4.51e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.433752	0.00e+00

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Expression of RAP1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAP1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RAP1A	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RAP1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAP1A	hsa-miR-3163	99.9523	NM_001010935
RAP1A	hsa-miR-6715a-3p	99.8254	NM_001010935
RAP1A	hsa-miR-4747-5p	98.9892	NM_002884
RAP1A	hsa-miR-5196-5p	98.9892	NM_002884
RAP1A	hsa-miR-518a-5p	98.3451	NM_001010935
RAP1A	hsa-miR-527	98.3451	NM_001010935
RAP1A	hsa-miR-340-5p	97.5162	NM_001010935
RAP1A	hsa-miR-548l	96.3151	NM_001010935
RAP1A	hsa-miR-142-5p	95.9251	NM_002884
RAP1A	hsa-miR-5590-3p	95.9251	NM_002884
RAP1A	hsa-miR-23a-3p	95.9086	NM_001010935
RAP1A	hsa-miR-23c	95.9086	NM_001010935
RAP1A	hsa-miR-23b-3p	95.9086	NM_001010935
RAP1A	hsa-miR-12129	95.6744	NM_001010935
RAP1A	hsa-miR-636	95.4546	NM_001010935
RAP1A	hsa-miR-3613-3p	94.5105	NM_002884
RAP1A	hsa-miR-4503	94.3136	NM_002884
RAP1A	hsa-miR-1277-5p	93.9596	NM_002884
RAP1A	hsa-miR-550a-3p	93.8878	NM_001010935
RAP1A	hsa-miR-3662	93.009	NM_001010935
RAP1A	hsa-miR-3156-5p	92.7619	NM_002884
RAP1A	hsa-miR-373-5p	92.7111	NM_002884
RAP1A	hsa-miR-371b-5p	92.7111	NM_002884
RAP1A	hsa-miR-616-5p	92.7111	NM_002884
RAP1A	hsa-miR-6754-3p	92.0995	NM_001010935
RAP1A	hsa-miR-4528	91.5995	NM_002884
RAP1A	hsa-miR-4801	91.2358	NM_001010935
RAP1A	hsa-miR-4731-3p	91.1773	NM_001010935
RAP1A	hsa-miR-656-3p	91.117	NM_002884
RAP1A	hsa-miR-1228-3p	90.7608	NM_001010935
RAP1A	hsa-miR-6837-3p	90.6456	NM_001010935
RAP1A	hsa-miR-412-3p	90.6456	NM_001010935
RAP1A	hsa-miR-4473	90.5446	NM_001010935
RAP1A	hsa-miR-4666a-3p	90.0469	NM_001010935
RAP1A	hsa-miR-200c-5p	89.8327	NM_001010935
RAP1A	hsa-miR-149-5p	89.5808	NM_001010935
RAP1A	hsa-miR-9851-5p	89.4592	NM_001010935
RAP1A	hsa-miR-4282	89.3888	NM_002884
RAP1A	hsa-miR-5683	89.1312	NM_001010935
RAP1A	hsa-miR-670-3p	88.523	NM_002884
RAP1A	hsa-miR-29a-3p	88.4664	NM_001010935
RAP1A	hsa-miR-29b-3p	88.4664	NM_001010935
RAP1A	hsa-miR-29c-3p	88.4664	NM_001010935
RAP1A	hsa-miR-5692a	88.1874	NM_001010935
RAP1A	hsa-miR-4526	87.6377	NM_002884
RAP1A	hsa-miR-3660	87.6377	NM_002884
RAP1A	hsa-miR-526b-5p	87.3599	NM_002884
RAP1A	hsa-miR-579-3p	87.3235	NM_002884
RAP1A	hsa-miR-664b-3p	87.3235	NM_002884
RAP1A	hsa-miR-559	87.2388	NM_001010935

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Motifs and transcription factors (TFs) regulating RAP1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAP1A	transfac_pro__M04862	NRF1 (directAnnotation).
RAP1A	metacluster_81.7	CREB1 (directAnnotation).
RAP1A	transfac_pro__M00492	STAT1 (directAnnotation).
RAP1A	transfac_pro__M04848	TAF1 (directAnnotation).
RAP1A	swissregulon__hs__ELK1	ELK1 (directAnnotation).
RAP1A	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
RAP1A	metacluster_183.4	ETS1 (inferredBy_Orthology).
RAP1A	metacluster_26.9	ZNF354B (directAnnotation).
RAP1A	jaspar__MA1125.1	ZNF384 (directAnnotation).
RAP1A	transfac_pro__M06364	ZNF841 (directAnnotation).
RAP1A	metacluster_167.5	EHF; ELF5; NFATC3; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIC; SPIC; STAT5A (directAnnotation). ETS1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIC (inferredBy_Orthology).
RAP1A	kznf__ZNF540_Imbeault2017_RP_ChIP-seq	ZNF540 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."