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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RALGPS2

Summary for RALGPS2

Gene information	Gene symbol	RALGPS2
	Ensembl ID	ENSG00000116191
	Entrez ID	55103
	Gene name	Ral GEF with PH domain and SH3 binding motif 2
	Synonyms	FLJ10244\|FLJ25604\|KIAA0351
	Gene type	protein_coding
	UniProtAcc	Q86X27

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Dataset with differentially expressed gene: RALGPS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.399729	7.01e-45
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.693935	2.91e-30
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.491995	4.15e-06
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.566302	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	1.32455	4.26e-03
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.278198	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.455589	0.00e+00

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Expression of RALGPS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RALGPS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RALGPS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RALGPS2	hsa-miR-454-3p	98.1452	NM_152663
RALGPS2	hsa-miR-3942-3p	97.9448	NM_152663
RALGPS2	hsa-miR-4760-3p	97.7626	NM_152663
RALGPS2	hsa-miR-944	96.8852	NM_152663
RALGPS2	hsa-miR-21-5p	96.8039	NM_152663
RALGPS2	hsa-miR-5002-5p	96.4679	NM_152663
RALGPS2	hsa-miR-590-5p	96.0857	NM_152663
RALGPS2	hsa-miR-301a-3p	95.9653	NM_152663
RALGPS2	hsa-miR-4295	95.9653	NM_152663
RALGPS2	hsa-miR-130a-3p	95.9653	NM_152663
RALGPS2	hsa-miR-3666	95.9653	NM_152663
RALGPS2	hsa-miR-301b-3p	95.9653	NM_152663
RALGPS2	hsa-miR-130b-3p	95.9653	NM_152663
RALGPS2	hsa-miR-5579-3p	95.6286	NM_152663
RALGPS2	hsa-miR-603	95.2111	NM_152663
RALGPS2	hsa-miR-670-5p	95.1772	NM_152663
RALGPS2	hsa-miR-520f-3p	95.0889	NM_152663
RALGPS2	hsa-miR-130b-5p	94.4475	NM_152663
RALGPS2	hsa-miR-12136	94.0926	NM_152663
RALGPS2	hsa-miR-345-3p	93.7061	NM_152663
RALGPS2	hsa-miR-4671-3p	93.4243	NM_152663
RALGPS2	hsa-miR-7-2-3p	93.1496	NM_152663
RALGPS2	hsa-miR-7-1-3p	93.1496	NM_152663
RALGPS2	hsa-miR-590-3p	92.7307	NM_152663
RALGPS2	hsa-miR-3692-3p	92.0725	NM_152663
RALGPS2	hsa-miR-222-5p	91.5466	NM_152663
RALGPS2	hsa-miR-8073	91.1428	NM_152663
RALGPS2	hsa-miR-221-5p	91.1428	NM_152663
RALGPS2	hsa-miR-524-5p	90.7802	NM_152663
RALGPS2	hsa-miR-520d-5p	90.7802	NM_152663
RALGPS2	hsa-miR-548au-3p	90.7192	NM_152663
RALGPS2	hsa-miR-33a-3p	90.6922	NM_152663
RALGPS2	hsa-miR-2052	90.0832	NM_152663
RALGPS2	hsa-miR-6758-3p	89.7771	NM_152663
RALGPS2	hsa-miR-4482-3p	89.7519	NM_152663
RALGPS2	hsa-miR-4753-3p	89.5992	NM_152663
RALGPS2	hsa-miR-4422	89.3613	NM_152663
RALGPS2	hsa-miR-3671	89.1149	NM_152663
RALGPS2	hsa-miR-5683	88.9854	NM_152663
RALGPS2	hsa-miR-3658	88.4238	NM_152663
RALGPS2	hsa-miR-18b-3p	88.2559	NM_152663
RALGPS2	hsa-miR-3182	87.913	NM_152663
RALGPS2	hsa-miR-6835-3p	87.1467	NM_152663
RALGPS2	hsa-miR-130a-5p	86.7707	NM_152663
RALGPS2	hsa-miR-377-3p	86.7093	NM_152663
RALGPS2	hsa-miR-4668-3p	86.387	NM_152663
RALGPS2	hsa-miR-153-3p	85.9959	NM_152663
RALGPS2	hsa-miR-1273h-3p	85.9395	NM_152663
RALGPS2	hsa-miR-3714	85.2365	NM_152663
RALGPS2	hsa-miR-888-5p	85.2343	NM_152663

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Motifs and transcription factors (TFs) regulating RALGPS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RALGPS2	transfac_pro__M07397	ZNF148 (directAnnotation).
RALGPS2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RALGPS2	cisbp__M07938	E2F1 (directAnnotation).
RALGPS2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RALGPS2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
RALGPS2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RALGPS2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RALGPS2	transfac_pro__M01837	KLF11 (directAnnotation).
RALGPS2	hdpi__TP73	TP73 (directAnnotation).
RALGPS2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
RALGPS2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RALGPS2	jaspar__MA0748.2	YY2 (directAnnotation).
RALGPS2	swissregulon__hs__KLF6	KLF6 (directAnnotation).
RALGPS2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
RALGPS2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RALGPS2	transfac_pro__M01175	ZBTB7B (directAnnotation).
RALGPS2	transfac_pro__M00716	ZBTB14 (directAnnotation).
RALGPS2	jaspar__MA1122.1	TFDP1 (directAnnotation).
RALGPS2	transfac_pro__M07297	MAZ (directAnnotation).
RALGPS2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
RALGPS2	metacluster_163.2	ZNF682 (directAnnotation).
RALGPS2	transfac_pro__M04916	TAF1 (directAnnotation).
RALGPS2	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
RALGPS2	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
RALGPS2	transfac_pro__M00938	E2F1 (directAnnotation).
RALGPS2	transfac_pro__M02090	E2F4 (directAnnotation).
RALGPS2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RALGPS2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
RALGPS2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RALGPS2	transfac_pro__M01303	SP1 (directAnnotation).
RALGPS2	transfac_pro__M05731	ZNF660 (directAnnotation).
RALGPS2	transfac_pro__M06539	ZNF483 (directAnnotation).
RALGPS2	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
RALGPS2	transfac_pro__M06661	ZNF426 (directAnnotation).
RALGPS2	taipale__ZNF524_full_ACCCTTGAACCC_repr	ZNF524 (directAnnotation).
RALGPS2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RALGPS2	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
RALGPS2	transfac_pro__M06491	ZNF770 (inferredBy_Orthology).
RALGPS2	metacluster_155.21	ZNF454; ZNF454 (directAnnotation).
RALGPS2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_1	ELK1; GCM1 (directAnnotation).
RALGPS2	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
RALGPS2	transfac_pro__M06811	ZNF528 (directAnnotation).
RALGPS2	taipale__CUX1_DBD_ATCRATNNNNNATCRAT_repr	CUX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."