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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB1A

Summary for RAB1A

Gene information	Gene symbol	RAB1A
	Ensembl ID	ENSG00000138069
	Entrez ID	5861
	Gene name	RAB1A, member RAS oncogene family
	Synonyms	RAB1\|YPT1
	Gene type	protein_coding
	UniProtAcc	P62820

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Dataset with differentially expressed gene: RAB1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.459561	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.278316	5.64e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.48582	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.341478	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.475334	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.318289	3.49e-15
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.262128	4.42e-04
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.277801	4.73e-08
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.279338	1.58e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.380454	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.457125	1.92e-13

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Expression of RAB1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB1A	hsa-miR-3065-5p	98.7897	NM_004161
RAB1A	hsa-miR-7847-3p	96.6297	NM_004161
RAB1A	hsa-miR-200b-5p	96.5814	NM_004161
RAB1A	hsa-miR-200a-5p	96.5814	NM_004161
RAB1A	hsa-miR-338-5p	96.5078	NM_004161
RAB1A	hsa-miR-8485	94.7444	NM_004161
RAB1A	hsa-miR-4691-3p	94.4518	NM_004161
RAB1A	hsa-miR-3688-3p	93.3028	NM_004161
RAB1A	hsa-miR-3941	93.1886	NM_004161
RAB1A	hsa-miR-6514-3p	92.6025	NM_004161
RAB1A	hsa-miR-6894-5p	92.5468	NM_004161
RAB1A	hsa-miR-192-3p	92.2738	NM_004161
RAB1A	hsa-miR-1323	91.9732	NM_004161
RAB1A	hsa-miR-937-5p	91.2154	NM_004161
RAB1A	hsa-miR-195-3p	90.2494	NM_004161
RAB1A	hsa-miR-16-2-3p	90.2494	NM_004161
RAB1A	hsa-miR-3606-5p	89.5441	NM_004161
RAB1A	hsa-miR-4742-5p	89.152	NM_004161
RAB1A	hsa-miR-101-3p	88.8976	NM_004161
RAB1A	hsa-miR-4799-5p	88.116	NM_004161
RAB1A	hsa-miR-335-3p	88.0602	NM_004161
RAB1A	hsa-miR-548o-3p	87.87	NM_004161
RAB1A	hsa-miR-19b-3p	87.321	NM_004161
RAB1A	hsa-miR-19a-3p	87.321	NM_004161
RAB1A	hsa-miR-3678-3p	86.9134	NM_004161
RAB1A	hsa-miR-5579-3p	86.8034	NM_004161
RAB1A	hsa-miR-618	86.7952	NM_004161
RAB1A	hsa-miR-6507-5p	86.514	NM_004161
RAB1A	hsa-miR-1912-5p	86.4688	NM_004161
RAB1A	hsa-miR-12126	86.0769	NM_004161
RAB1A	hsa-miR-205-3p	85.0579	NM_004161
RAB1A	hsa-miR-664a-3p	84.6098	NM_004161
RAB1A	hsa-miR-10522-5p	84.2927	NM_004161
RAB1A	hsa-miR-1184	83.8851	NM_004161
RAB1A	hsa-miR-4698	83.3206	NM_004161
RAB1A	hsa-miR-2467-3p	83.2729	NM_004161
RAB1A	hsa-miR-4677-3p	83.2079	NM_004161
RAB1A	hsa-miR-301a-5p	81.8993	NM_004161
RAB1A	hsa-miR-301b-5p	81.8993	NM_004161
RAB1A	hsa-miR-449b-3p	81.7669	NM_004161
RAB1A	hsa-miR-140-3p	81.0547	NM_004161
RAB1A	hsa-miR-634	80.9784	NM_004161
RAB1A	hsa-miR-4774-5p	80.827	NM_004161
RAB1A	hsa-miR-6508-5p	80.6344	NM_004161
RAB1A	hsa-miR-221-3p	80.2377	NM_004161
RAB1A	hsa-miR-222-3p	80.2377	NM_004161

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Motifs and transcription factors (TFs) regulating RAB1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB1A	metacluster_182.10	ZFX (directAnnotation).
RAB1A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
RAB1A	hdpi__TIMELESS	TIMELESS (directAnnotation).
RAB1A	transfac_pro__M02913	SP140 (inferredBy_Orthology).
RAB1A	swissregulon__hs__ELK1	ELK1 (directAnnotation).
RAB1A	transfac_pro__M00492	STAT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."