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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: QKI

Summary for QKI

Gene information	Gene symbol	QKI
	Ensembl ID	ENSG00000112531
	Entrez ID	9444
	Gene name	QKI, KH domain containing RNA binding
	Synonyms	QK3
	Gene type	protein_coding
	UniProtAcc	Q96PU8

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Dataset with differentially expressed gene: QKI

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.884928	3.12e-09
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.527092	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.250091	4.03e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.315184	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.523209	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.303771	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.350074	6.04e-19

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Expression of QKI in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to QKI

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
QKI	Regulation by the Disease Microenvironment

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MicroRNAs (miRNA) regulating QKI

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
QKI	hsa-miR-10523-5p	99.9079	NM_206854
QKI	hsa-miR-590-3p	99.6205	NM_206853
QKI	hsa-miR-5011-5p	99.5788	NM_206855
QKI	hsa-miR-5692a	99.2531	NM_206855
QKI	hsa-miR-551b-5p	99.1865	NM_206855
QKI	hsa-let-7b-3p	98.8442	NM_206855
QKI	hsa-miR-98-3p	98.8442	NM_206855
QKI	hsa-let-7a-3p	98.8442	NM_206855
QKI	hsa-let-7f-1-3p	98.8442	NM_206855
QKI	hsa-miR-429	98.789	NM_206855
QKI	hsa-miR-200c-3p	98.789	NM_206855
QKI	hsa-miR-200b-3p	98.789	NM_206855
QKI	hsa-miR-3148	98.7842	NM_206854
QKI	hsa-miR-607	98.535	NM_206854
QKI	hsa-miR-124-3p	98.3697	NM_206855
QKI	hsa-miR-506-3p	98.3697	NM_206855
QKI	hsa-miR-4701-3p	98.1658	NM_001301085
QKI	hsa-miR-6736-5p	98.1658	NM_001301085
QKI	hsa-miR-1262	98.1658	NM_001301085
QKI	hsa-miR-548az-3p	98.1168	NM_206855
QKI	hsa-miR-4735-5p	98.0632	NM_206853
QKI	hsa-miR-548ar-3p	98.0191	NM_206855
QKI	hsa-miR-4666a-3p	98.0044	NM_206854
QKI	hsa-miR-5582-3p	97.5726	NM_206855
QKI	hsa-miR-3613-3p	97.5497	NM_206855
QKI	hsa-miR-548e-3p	97.4216	NM_206855
QKI	hsa-miR-548bc	97.4216	NM_206855
QKI	hsa-miR-548f-3p	97.4216	NM_206855
QKI	hsa-miR-548a-3p	97.2482	NM_206855
QKI	hsa-miR-3910	97.2273	NM_206855
QKI	hsa-miR-3163	97.0584	NM_206855
QKI	hsa-miR-4422	97.0508	NM_206855
QKI	hsa-miR-190a-3p	96.6633	NM_206855
QKI	hsa-miR-152-3p	96.6191	NM_206855
QKI	hsa-miR-148b-3p	96.6191	NM_206855
QKI	hsa-miR-148a-3p	96.6191	NM_206855
QKI	hsa-miR-545-5p	96.5529	NM_206855
QKI	hsa-miR-548c-3p	96.4877	NM_206855
QKI	hsa-miR-4724-3p	96.4651	NM_206855
QKI	hsa-miR-513b-3p	95.9885	NM_206855
QKI	hsa-miR-4775	95.8796	NM_206855
QKI	hsa-miR-4274	95.865	NM_206855
QKI	hsa-miR-1252-5p	95.8345	NM_206853
QKI	hsa-miR-548x-3p	95.8082	NM_206853
QKI	hsa-miR-548aj-3p	95.8082	NM_206853
QKI	hsa-miR-340-5p	95.6303	NM_206855
QKI	hsa-miR-10527-5p	95.5079	NM_206853
QKI	hsa-miR-4666a-5p	95.4044	NM_206854
QKI	hsa-miR-32-3p	95.2522	NM_206855
QKI	hsa-miR-4517	95.0131	NM_206855

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Motifs and transcription factors (TFs) regulating QKI

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
QKI	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
QKI	cisbp__M00968	MTF2 (directAnnotation).
QKI	metacluster_160.20	JUND; PRDM15 (directAnnotation).
QKI	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
QKI	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
QKI	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
QKI	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
QKI	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
QKI	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
QKI	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
QKI	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
QKI	transfac_pro__M00938	E2F1 (directAnnotation).
QKI	transfac_pro__M04817	ZBTB33 (directAnnotation).
QKI	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
QKI	transfac_pro__M12697	ZNF142 (directAnnotation).
QKI	metacluster_175.1	ZNF283 (directAnnotation).
QKI	cisbp__M00788	ZFY (inferredBy_Orthology).
QKI	tfdimers__MD00364	WT1 (directAnnotation).
QKI	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
QKI	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
QKI	hdpi__ZNF304	ZNF304 (directAnnotation).
QKI	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
QKI	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
QKI	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
QKI	transfac_pro__M01973	PLAG1 (directAnnotation).
QKI	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
QKI	metacluster_198.3	ZFP64 (directAnnotation).
QKI	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
QKI	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
QKI	metacluster_143.13	ZBTB7A (directAnnotation).
QKI	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
QKI	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
QKI	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
QKI	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
QKI	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
QKI	metacluster_144.13	HIC1; HIC1 (directAnnotation).
QKI	transfac_pro__M00514	ATF4 (directAnnotation).
QKI	transfac_pro__M00665	SP3 (directAnnotation).
QKI	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
QKI	transfac_pro__M02898	SMAD3 (directAnnotation).
QKI	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
QKI	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
QKI	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
QKI	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
QKI	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
QKI	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
QKI	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
QKI	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
QKI	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
QKI	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."