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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PPP3R1

Summary for PPP3R1

Gene information	Gene symbol	PPP3R1
	Ensembl ID	ENSG00000221823
	Entrez ID	5534
	Gene name	protein phosphatase 3 regulatory subunit B, alpha
	Synonyms	CALNB1\|CNB\|CNB1
	Gene type	protein_coding
	UniProtAcc	P63098

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Dataset with differentially expressed gene: PPP3R1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.34878	6.23e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.281825	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.25563	0.00e+00

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Expression of PPP3R1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP3R1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP3R1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP3R1	hsa-miR-5011-5p	99.613	NM_000945
PPP3R1	hsa-miR-3924	99.3115	NM_000945
PPP3R1	hsa-miR-4719	97.407	NM_000945
PPP3R1	hsa-miR-30a-5p	96.8355	NM_000945
PPP3R1	hsa-miR-30b-5p	96.8355	NM_000945
PPP3R1	hsa-miR-30e-5p	96.8355	NM_000945
PPP3R1	hsa-miR-30d-5p	96.8355	NM_000945
PPP3R1	hsa-miR-30c-5p	96.8355	NM_000945
PPP3R1	hsa-miR-548ba	96.6752	NM_000945
PPP3R1	hsa-miR-548ai	96.6752	NM_000945
PPP3R1	hsa-miR-548ag	96.6752	NM_000945
PPP3R1	hsa-miR-570-5p	96.6752	NM_000945
PPP3R1	hsa-miR-3944-5p	96.6711	NM_000945
PPP3R1	hsa-miR-5580-3p	96.5502	NM_000945
PPP3R1	hsa-miR-298	96.5332	NM_000945
PPP3R1	hsa-miR-651-3p	96.5142	NM_000945
PPP3R1	hsa-miR-12124	96.3113	NM_000945
PPP3R1	hsa-let-7c-3p	96.1759	NM_000945
PPP3R1	hsa-miR-12125	96.0079	NM_000945
PPP3R1	hsa-miR-3163	95.9752	NM_000945
PPP3R1	hsa-miR-4505	95.5093	NM_000945
PPP3R1	hsa-miR-5787	95.5093	NM_000945
PPP3R1	hsa-miR-4666a-5p	95.348	NM_000945
PPP3R1	hsa-miR-543	94.7628	NM_000945
PPP3R1	hsa-miR-7-1-3p	94.5271	NM_000945
PPP3R1	hsa-miR-7-2-3p	94.5271	NM_000945
PPP3R1	hsa-miR-181c-5p	94.2642	NM_000945
PPP3R1	hsa-miR-181a-5p	94.2642	NM_000945
PPP3R1	hsa-miR-4262	94.2642	NM_000945
PPP3R1	hsa-miR-181d-5p	94.2642	NM_000945
PPP3R1	hsa-miR-181b-5p	94.2642	NM_000945
PPP3R1	hsa-miR-491-3p	93.8651	NM_000945
PPP3R1	hsa-miR-548ar-3p	93.6769	NM_000945
PPP3R1	hsa-miR-190a-3p	93.3748	NM_000945
PPP3R1	hsa-miR-520d-5p	93.23	NM_000945
PPP3R1	hsa-miR-524-5p	93.23	NM_000945
PPP3R1	hsa-miR-96-5p	92.7543	NM_000945
PPP3R1	hsa-miR-105-5p	92.5787	NM_000945
PPP3R1	hsa-miR-7853-5p	92.5787	NM_000945
PPP3R1	hsa-miR-377-3p	92.4841	NM_000945
PPP3R1	hsa-miR-12120	92.4752	NM_000945
PPP3R1	hsa-miR-3126-5p	92.3371	NM_000945
PPP3R1	hsa-miR-6875-5p	92.3371	NM_000945
PPP3R1	hsa-miR-4516	92.2839	NM_000945
PPP3R1	hsa-miR-6866-3p	92.1493	NM_000945
PPP3R1	hsa-miR-188-5p	92.1493	NM_000945
PPP3R1	hsa-miR-12123	92.0338	NM_000945
PPP3R1	hsa-miR-222-3p	91.8766	NM_000945
PPP3R1	hsa-miR-221-3p	91.8766	NM_000945
PPP3R1	hsa-miR-2467-5p	91.8174	NM_000945

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Motifs and transcription factors (TFs) regulating PPP3R1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP3R1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
PPP3R1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
PPP3R1	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
PPP3R1	metacluster_84.2	RARA (directAnnotation).
PPP3R1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
PPP3R1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
PPP3R1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
PPP3R1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PPP3R1	transfac_pro__M05479	ZNF580 (directAnnotation).
PPP3R1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PPP3R1	cisbp__M00341	PAX6 (directAnnotation).
PPP3R1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
PPP3R1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PPP3R1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
PPP3R1	tfdimers__MD00151	CHURC1 (directAnnotation).
PPP3R1	tfdimers__MD00391	KLF4 (directAnnotation).
PPP3R1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
PPP3R1	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
PPP3R1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
PPP3R1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
PPP3R1	metacluster_3.14	WT1; WT1 (directAnnotation).
PPP3R1	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
PPP3R1	transfac_public__M00491	PATZ1 (directAnnotation).
PPP3R1	transfac_pro__M07397	ZNF148 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PPP3R1	"Myristic acid"	DB08231	small molecule
PPP3R1	"Voclosporin"	DB11693	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."