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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PLEKHO1

Summary for PLEKHO1

Gene information	Gene symbol	PLEKHO1
	Ensembl ID	ENSG00000023902
	Entrez ID	51177
	Gene name	pleckstrin homology domain containing O1
	Synonyms	CKIP-1\|OC120
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PLEKHO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.369873	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.353452	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.260456	2.65e-02
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.270765	4.66e-33
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.427416	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.383997	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.286651	1.11e-20
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.508741	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.304905	0.00e+00

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Expression of PLEKHO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLEKHO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLEKHO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLEKHO1	hsa-miR-423-5p	91.5722	NM_016274
PLEKHO1	hsa-miR-3184-5p	91.5722	NM_016274
PLEKHO1	hsa-miR-4505	91.0776	NM_016274
PLEKHO1	hsa-miR-5787	89.8018	NM_016274
PLEKHO1	hsa-miR-6865-3p	86.2633	NM_001304722
PLEKHO1	hsa-let-7e-5p	84.0076	NM_016274
PLEKHO1	hsa-miR-4500	84.0076	NM_016274
PLEKHO1	hsa-miR-98-5p	84.0076	NM_016274
PLEKHO1	hsa-let-7f-5p	84.0076	NM_016274
PLEKHO1	hsa-let-7c-5p	84.0076	NM_016274
PLEKHO1	hsa-let-7i-5p	84.0076	NM_016274
PLEKHO1	hsa-let-7b-5p	84.0076	NM_016274
PLEKHO1	hsa-let-7g-5p	84.0076	NM_016274
PLEKHO1	hsa-let-7a-5p	84.0076	NM_016274
PLEKHO1	hsa-miR-4458	83.9195	NM_016274
PLEKHO1	hsa-miR-202-3p	83.9195	NM_016274
PLEKHO1	hsa-let-7d-5p	83.9195	NM_016274

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Motifs and transcription factors (TFs) regulating PLEKHO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLEKHO1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PLEKHO1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PLEKHO1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
PLEKHO1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PLEKHO1	jaspar__MA1721.1	ZNF93 (directAnnotation).
PLEKHO1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PLEKHO1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
PLEKHO1	transfac_pro__M01303	SP1 (directAnnotation).
PLEKHO1	transfac_public__M00491	PATZ1 (directAnnotation).
PLEKHO1	transfac_pro__M07397	ZNF148 (directAnnotation).
PLEKHO1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
PLEKHO1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
PLEKHO1	jaspar__MA1708.1	ETV7 (directAnnotation).
PLEKHO1	metacluster_168.17	ZNF417; ZNF587 (directAnnotation).
PLEKHO1	jaspar__MA1154.1	ZNF282 (directAnnotation).
PLEKHO1	taipale_tf_pairs__FLI1_ETV7_NSMGGACGGAYNTCCKSN_CAP	ETV7; FLI1 (directAnnotation).
PLEKHO1	taipale_tf_pairs__CUX1_SOX15_NATCRATNNNNNNNAACAATRS_CAP_repr	CUX1; SOX15 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."