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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NFIL3

Summary for NFIL3

Gene information	Gene symbol	NFIL3
	Ensembl ID	ENSG00000165030
	Entrez ID	4783
	Gene name	nuclear factor, interleukin 3 regulated
	Synonyms	E4BP4\|IL3BP1\|NF-IL3A\|NFIL3A
	Gene type	protein_coding
	UniProtAcc	Q16649

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Dataset with differentially expressed gene: NFIL3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.21122	9.15e-03
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.495793	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.455469	9.71e-31
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.303148	1.83e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.306959	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.265918	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.430136	8.69e-42

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Expression of NFIL3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NFIL3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NFIL3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NFIL3	hsa-miR-603	96.7026	NM_001289999
NFIL3	hsa-miR-128-3p	95.9257	NM_001289999
NFIL3	hsa-miR-216a-3p	95.9257	NM_001289999
NFIL3	hsa-miR-3681-3p	95.1353	NM_001289999
NFIL3	hsa-miR-4514	92.3781	NM_001289999
NFIL3	hsa-miR-4692	92.3781	NM_001289999
NFIL3	hsa-miR-1825	91.4372	NM_001289999
NFIL3	hsa-miR-501-5p	91.2916	NM_001289999
NFIL3	hsa-miR-199a-5p	90.6214	NM_001289999
NFIL3	hsa-miR-199b-5p	90.6214	NM_001289999
NFIL3	hsa-miR-3913-3p	88.2121	NM_001289999
NFIL3	hsa-miR-3065-5p	87.2797	NM_001289999
NFIL3	hsa-miR-759	86.7251	NM_001289999
NFIL3	hsa-miR-655-3p	86.4098	NM_001289999
NFIL3	hsa-miR-374c-5p	86.4098	NM_001289999
NFIL3	hsa-miR-9900	84.4169	NM_001289999
NFIL3	hsa-miR-4738-3p	83.9192	NM_001289999
NFIL3	hsa-miR-203a-3p	83.2562	NM_001289999

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Motifs and transcription factors (TFs) regulating NFIL3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NFIL3	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
NFIL3	cisbp__M01863	ZNF711 (inferredBy_Orthology).
NFIL3	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
NFIL3	transfac_pro__M00938	E2F1 (directAnnotation).
NFIL3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
NFIL3	transfac_pro__M04817	ZBTB33 (directAnnotation).
NFIL3	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
NFIL3	metacluster_175.1	ZNF283 (directAnnotation).
NFIL3	cisbp__M00788	ZFY (inferredBy_Orthology).
NFIL3	tfdimers__MD00364	WT1 (directAnnotation).
NFIL3	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NFIL3	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
NFIL3	hdpi__ZNF304	ZNF304 (directAnnotation).
NFIL3	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
NFIL3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
NFIL3	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
NFIL3	transfac_pro__M01973	PLAG1 (directAnnotation).
NFIL3	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
NFIL3	metacluster_198.3	ZFP64 (directAnnotation).
NFIL3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
NFIL3	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
NFIL3	metacluster_143.13	ZBTB7A (directAnnotation).
NFIL3	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
NFIL3	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
NFIL3	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
NFIL3	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
NFIL3	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
NFIL3	metacluster_144.13	HIC1; HIC1 (directAnnotation).
NFIL3	transfac_pro__M00514	ATF4 (directAnnotation).
NFIL3	transfac_pro__M00665	SP3 (directAnnotation).
NFIL3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NFIL3	transfac_pro__M02898	SMAD3 (directAnnotation).
NFIL3	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
NFIL3	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
NFIL3	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
NFIL3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NFIL3	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
NFIL3	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
NFIL3	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
NFIL3	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
NFIL3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
NFIL3	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
NFIL3	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
NFIL3	taipale_tf_pairs__ELK1_PAX5_RSCGGAACYACGCWYSANTG_CAP_repr	ELK1; PAX5 (directAnnotation).
NFIL3	transfac_pro__M04855	IRF4 (directAnnotation).
NFIL3	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
NFIL3	metacluster_162.5	NR1D1; NR1D1; RORA; RORA; RORA; RORA; RORA; RORC; RORC (directAnnotation). NR1D1; PPARG; RORA; RORC (inferredBy_Orthology).
NFIL3	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	CEBPB; GCM1 (directAnnotation).
NFIL3	transfac_pro__M06104	ZNF16 (directAnnotation).
NFIL3	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."