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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NCOR1

Summary for NCOR1

Gene information	Gene symbol	NCOR1
	Ensembl ID	ENSG00000141027
	Entrez ID	9611
	Gene name	nuclear receptor corepressor 1
	Synonyms	hCIT529I10\|hN-CoR\|KIAA1047\|MGC104216\|N-CoR\|PPP1R109\|TRAC1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: NCOR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.662706	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.66391	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.273444	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.259014	8.97e-35
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.312133	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.271079	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.263554	4.62e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.842551	8.82e-04
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.312823	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.291366	9.83e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.520821	3.86e-38
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.354388	1.10e-13
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.29212	1.85e-21
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.341527	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.257363	0.00e+00

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Expression of NCOR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NCOR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NCOR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NCOR1	hsa-miR-548aj-3p	97.5709	NM_001190440
NCOR1	hsa-miR-548x-3p	97.5709	NM_001190440
NCOR1	hsa-miR-8068	96.9449	NM_001190440
NCOR1	hsa-miR-548ae-3p	96.9399	NM_001190440
NCOR1	hsa-miR-548j-3p	96.9399	NM_001190440
NCOR1	hsa-miR-548am-3p	96.9399	NM_001190440
NCOR1	hsa-miR-548ah-3p	96.9399	NM_001190440
NCOR1	hsa-miR-548aq-3p	96.9399	NM_001190440
NCOR1	hsa-miR-4741	96.6369	NM_001190440
NCOR1	hsa-miR-4675	96.6369	NM_001190440
NCOR1	hsa-miR-6829-5p	96.5026	NM_001190440
NCOR1	hsa-miR-618	96.0192	NM_001190440
NCOR1	hsa-miR-513b-5p	95.5707	NM_001190440
NCOR1	hsa-miR-1587	95.2454	NM_001190440
NCOR1	hsa-miR-642b-3p	94.1818	NM_001190440
NCOR1	hsa-miR-642a-3p	94.1818	NM_001190440
NCOR1	hsa-miR-4699-3p	94.1374	NM_001190440
NCOR1	hsa-miR-497-3p	94.0615	NM_001190440
NCOR1	hsa-miR-3974	94.026	NM_001190438
NCOR1	hsa-miR-548c-3p	93.3294	NM_001190440
NCOR1	hsa-miR-4722-5p	93.0295	NM_001190440
NCOR1	hsa-miR-3620-5p	92.8028	NM_001190440
NCOR1	hsa-miR-4492	92.7142	NM_001190440
NCOR1	hsa-miR-1266-5p	91.6341	NM_001190440
NCOR1	hsa-miR-6086	91.4238	NM_001190440
NCOR1	hsa-miR-3184-3p	90.6966	NM_001190440
NCOR1	hsa-miR-377-5p	90.51	NM_001190440
NCOR1	hsa-miR-4518	90.1583	NM_001190440
NCOR1	hsa-miR-1244	89.2746	NM_001190438
NCOR1	hsa-miR-5089-3p	88.8319	NM_001190440
NCOR1	hsa-miR-584-5p	88.8119	NM_001190440
NCOR1	hsa-miR-449c-5p	88.6784	NM_001190440
NCOR1	hsa-miR-34b-5p	88.6784	NM_001190440
NCOR1	hsa-miR-2682-5p	88.6784	NM_001190440
NCOR1	hsa-miR-3617-5p	88.5277	NM_001190440
NCOR1	hsa-miR-641	88.5277	NM_001190440
NCOR1	hsa-miR-4498	88.4668	NM_001190440
NCOR1	hsa-miR-12117	86.1668	NM_001190440
NCOR1	hsa-miR-548n	85.9849	NM_001190440
NCOR1	hsa-miR-762	85.3557	NM_001190440
NCOR1	hsa-miR-5001-5p	85.3557	NM_001190440
NCOR1	hsa-miR-6789-5p	84.5433	NM_001190440
NCOR1	hsa-miR-8054	83.4971	NM_001190440
NCOR1	hsa-miR-548k	83.4971	NM_001190440
NCOR1	hsa-miR-548av-5p	83.4971	NM_001190440
NCOR1	hsa-miR-6077	83.3324	NM_001190440
NCOR1	hsa-miR-548aw	82.3655	NM_001190440
NCOR1	hsa-miR-5683	81.7293	NM_001190440
NCOR1	hsa-miR-624-5p	81.6752	NM_001190440
NCOR1	hsa-miR-7161-5p	81.6235	NM_001190440

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Motifs and transcription factors (TFs) regulating NCOR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NCOR1	metacluster_81.7	CREB1 (directAnnotation).
NCOR1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NCOR1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
NCOR1	transfac_pro__M04748	GABPA (directAnnotation).
NCOR1	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
NCOR1	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
NCOR1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
NCOR1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
NCOR1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
NCOR1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
NCOR1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
NCOR1	transfac_pro__M04817	ZBTB33 (directAnnotation).
NCOR1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
NCOR1	tfdimers__MD00483	ZBTB14 (directAnnotation).
NCOR1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
NCOR1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NCOR1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
NCOR1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
NCOR1	hdpi__FEZF2	FEZF2 (directAnnotation).
NCOR1	transfac_pro__M07310	SP5 (directAnnotation).
NCOR1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
NCOR1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
NCOR1	metacluster_155.11	SPZ1 (directAnnotation).
NCOR1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
NCOR1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
NCOR1	hdpi__HIP2	UBE2K (directAnnotation).
NCOR1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
NCOR1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
NCOR1	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
NCOR1	transfac_pro__M07317	CTBP1 (directAnnotation).
NCOR1	transfac_pro__M12697	ZNF142 (directAnnotation).
NCOR1	transfac_pro__M00716	ZBTB14 (directAnnotation).
NCOR1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
NCOR1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
NCOR1	transfac_pro__M04893	TAF1 (directAnnotation).
NCOR1	transfac_pro__M01253	CNOT3 (directAnnotation).
NCOR1	transfac_pro__M01783	SP2 (directAnnotation).
NCOR1	hdpi__RARA	RARA (directAnnotation).
NCOR1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
NCOR1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NCOR1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
NCOR1	cisbp__M08228	PAX5 (directAnnotation).
NCOR1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
NCOR1	transfac_pro__M00938	E2F1 (directAnnotation).
NCOR1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
NCOR1	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
NCOR1	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NCOR1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
NCOR1	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
NCOR1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."