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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NAP1L1

Summary for NAP1L1

Gene information	Gene symbol	NAP1L1
	Ensembl ID	ENSG00000187109
	Entrez ID	4673
	Gene name	nucleosome assembly protein 1 like 1
	Synonyms	MGC23410\|MGC8688\|NAP1\|NAP1L\|NRP
	Gene type	protein_coding
	UniProtAcc	P55209

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Dataset with differentially expressed gene: NAP1L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.264013	3.88e-09
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.325306	5.58e-28
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.331718	2.16e-13
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.439707	3.17e-09
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.286775	7.92e-06
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.682208	2.43e-15
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.49106	1.86e-19
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	1.00851	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD8+ T cells	-0.274173	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Mono/Macro	-0.257305	2.64e-10
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.526227	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	post	Malignant cells	0.34998	1.61e-43
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.351643	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.773584	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	0.427541	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.397467	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.23144	6.39e-08
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.250726	1.96e-09
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.258627	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.481202	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.535418	1.07e-37
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.493169	0.00e+00

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Expression of NAP1L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NAP1L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NAP1L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NAP1L1	hsa-miR-4500	98.7453	NM_004537
NAP1L1	hsa-miR-3613-3p	98.149	NM_004537
NAP1L1	hsa-let-7e-5p	98.1208	NM_004537
NAP1L1	hsa-let-7g-5p	98.1208	NM_004537
NAP1L1	hsa-let-7c-5p	98.1208	NM_004537
NAP1L1	hsa-miR-98-5p	98.1208	NM_004537
NAP1L1	hsa-let-7i-5p	98.1208	NM_004537
NAP1L1	hsa-let-7a-5p	98.1208	NM_004537
NAP1L1	hsa-let-7f-5p	98.1208	NM_004537
NAP1L1	hsa-let-7b-5p	98.1208	NM_004537
NAP1L1	hsa-miR-4458	97.8957	NM_004537
NAP1L1	hsa-let-7d-5p	97.8957	NM_004537
NAP1L1	hsa-miR-541-5p	97.2037	NM_004537
NAP1L1	hsa-miR-548b-3p	96.8276	NM_004537
NAP1L1	hsa-miR-3180-5p	96.6341	NM_004537
NAP1L1	hsa-miR-5584-5p	95.4793	NM_001307924
NAP1L1	hsa-miR-6831-5p	95.3324	NM_004537
NAP1L1	hsa-miR-875-3p	95.1093	NM_004537
NAP1L1	hsa-miR-3927-3p	94.3999	NM_004537
NAP1L1	hsa-miR-511-5p	94.122	NM_004537
NAP1L1	hsa-miR-6830-5p	93.9338	NM_004537
NAP1L1	hsa-miR-202-3p	93.3614	NM_004537
NAP1L1	hsa-miR-676-5p	93.0679	NM_139207
NAP1L1	hsa-miR-3148	92.7929	NM_004537
NAP1L1	hsa-miR-590-3p	90.9227	NM_004537
NAP1L1	hsa-miR-8055	90.4313	NM_139207
NAP1L1	hsa-miR-7-1-3p	90.2694	NM_004537
NAP1L1	hsa-miR-7-2-3p	90.2694	NM_004537
NAP1L1	hsa-miR-582-5p	90.1734	NM_004537
NAP1L1	hsa-miR-4773	89.7963	NM_004537
NAP1L1	hsa-miR-4477a	89.2003	NM_004537
NAP1L1	hsa-miR-335-3p	88.7009	NM_004537
NAP1L1	hsa-miR-3682-3p	88.6602	NM_001307924
NAP1L1	hsa-miR-3922-5p	88.6171	NM_004537
NAP1L1	hsa-miR-4503	88.3521	NM_139207
NAP1L1	hsa-miR-181a-2-3p	87.7606	NM_001307924
NAP1L1	hsa-miR-149-5p	87.7445	NM_001307924
NAP1L1	hsa-miR-216a-5p	87.6332	NM_139207
NAP1L1	hsa-miR-196b-5p	87.0741	NM_004537
NAP1L1	hsa-miR-196a-5p	87.0741	NM_004537
NAP1L1	hsa-miR-6515-3p	87.0428	NM_139207
NAP1L1	hsa-miR-135b-3p	86.0534	NM_001307924
NAP1L1	hsa-miR-135a-2-3p	86.0534	NM_001307924
NAP1L1	hsa-miR-4712-5p	85.9886	NM_004537
NAP1L1	hsa-miR-770-5p	85.9886	NM_004537
NAP1L1	hsa-miR-4511	85.5415	NM_139207
NAP1L1	hsa-miR-5195-3p	85.4465	NM_004537
NAP1L1	hsa-miR-145-5p	85.4465	NM_004537
NAP1L1	hsa-miR-6748-3p	85.1236	NM_004537
NAP1L1	hsa-miR-548x-3p	85.1148	NM_004537

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Motifs and transcription factors (TFs) regulating NAP1L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NAP1L1	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
NAP1L1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
NAP1L1	jaspar__MA1122.1	TFDP1 (directAnnotation).
NAP1L1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
NAP1L1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NAP1L1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
NAP1L1	tfdimers__MD00151	CHURC1 (directAnnotation).
NAP1L1	tfdimers__MD00391	KLF4 (directAnnotation).
NAP1L1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
NAP1L1	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
NAP1L1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
NAP1L1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NAP1L1	transfac_pro__M01973	PLAG1 (directAnnotation).
NAP1L1	transfac_pro__M12697	ZNF142 (directAnnotation).
NAP1L1	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
NAP1L1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NAP1L1	jaspar__MA0748.2	YY2 (directAnnotation).
NAP1L1	transfac_pro__M01303	SP1 (directAnnotation).
NAP1L1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
NAP1L1	metacluster_3.14	WT1; WT1 (directAnnotation).
NAP1L1	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
NAP1L1	transfac_public__M00491	PATZ1 (directAnnotation).
NAP1L1	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
NAP1L1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
NAP1L1	transfac_pro__M07397	ZNF148 (directAnnotation).
NAP1L1	transfac_pro__M06259	ZNF91 (directAnnotation).
NAP1L1	hdpi__ZNF76	ZNF76 (directAnnotation).
NAP1L1	taipale_tf_pairs__ETV2_HOXB13_NCCGGAAGTYRTAAAN_CAP	ETV2; HOXB13 (directAnnotation).
NAP1L1	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
NAP1L1	transfac_pro__M05474	ZNF639 (directAnnotation).
NAP1L1	cisbp__M00808	MYPOP (inferredBy_Orthology).
NAP1L1	transfac_pro__M05529	ZBTB5 (inferredBy_Orthology).
NAP1L1	metacluster_113.3	MYBL1; MYBL1; MYBL2; MYBL2; OVOL1; OVOL2 (directAnnotation). MYB; MYBL1; MYBL1; MYBL1; MYBL1; MYBL2; OVOL1 (inferredBy_Orthology).
NAP1L1	hdpi__MLX	MLX (directAnnotation).
NAP1L1	taipale_tf_pairs__MYBL1_EOMES_NNSYGNCNAACNNNNNNCACRCNN_CAP_repr	EOMES; MYBL1 (directAnnotation).
NAP1L1	hocomoco__E2F8_HUMAN.H11MO.0.D	E2F8 (directAnnotation).
NAP1L1	transfac_pro__M06096	ZNF682 (directAnnotation).
NAP1L1	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
NAP1L1	taipale_cyt_meth__NKX2-3_NTCGTTGAN_eDBD_meth	NKX2-3 (directAnnotation).
NAP1L1	metacluster_144.9	SP2 (directAnnotation).
NAP1L1	jaspar__MA0863.1	MTF1 (directAnnotation).
NAP1L1	transfac_pro__M07362	NANOG (directAnnotation). NANOGP8 (inferredBy_Orthology).
NAP1L1	transfac_pro__M06473	ZNF440 (directAnnotation).
NAP1L1	metacluster_140.1	BCL11B; BCL11B (directAnnotation).
NAP1L1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
NAP1L1	transfac_pro__M06863	ZNF789 (directAnnotation).
NAP1L1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
NAP1L1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
NAP1L1	transfac_pro__M02089	E2F3 (directAnnotation).
NAP1L1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."