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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MTSS1

Summary for MTSS1

Gene information	Gene symbol	MTSS1
	Ensembl ID	ENSG00000170873
	Entrez ID	9788
	Gene name	MTSS I-BAR domain containing 1
	Synonyms	KIAA0429\|MIM\|MIMA\|MIMB
	Gene type	protein_coding
	UniProtAcc	O43312

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Dataset with differentially expressed gene: MTSS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.279613	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.250555	8.67e-22
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.284511	4.18e-14
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.456807	4.51e-31
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-0.57414	5.36e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.491741	1.37e-32
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	B cells	0.256499	2.52e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.282293	1.59e-29
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.508981	0.00e+00

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Expression of MTSS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MTSS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MTSS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MTSS1	hsa-miR-1283	99.1928	NM_001282971
MTSS1	hsa-miR-182-5p	98.9204	NM_001282971
MTSS1	hsa-miR-520d-5p	98.9191	NM_001282971
MTSS1	hsa-miR-524-5p	98.9191	NM_001282971
MTSS1	hsa-miR-935	98.818	NM_001282971
MTSS1	hsa-miR-96-5p	98.593	NM_001282971
MTSS1	hsa-miR-12133	98.0465	NM_001282971
MTSS1	hsa-miR-1271-5p	98.0465	NM_001282971
MTSS1	hsa-miR-4699-3p	95.7508	NM_001282971
MTSS1	hsa-miR-6835-3p	95.6069	NM_001282971
MTSS1	hsa-miR-4422	95.2732	NM_001282971
MTSS1	hsa-miR-576-5p	93.8044	NM_001282971
MTSS1	hsa-miR-5690	93.7994	NM_001282971
MTSS1	hsa-miR-9-3p	93.5481	NM_001282971
MTSS1	hsa-miR-541-3p	93.052	NM_001282971
MTSS1	hsa-miR-654-5p	93.052	NM_001282971
MTSS1	hsa-miR-4778-5p	93.0347	NM_001282971
MTSS1	hsa-miR-4803	92.9358	NM_001282971
MTSS1	hsa-miR-520e-5p	92.5252	NM_001282971
MTSS1	hsa-miR-329-5p	92.4953	NM_001282971
MTSS1	hsa-miR-135a-5p	92.3594	NM_001282971
MTSS1	hsa-miR-135b-5p	92.3594	NM_001282971
MTSS1	hsa-miR-548av-3p	91.4553	NM_001282971
MTSS1	hsa-miR-548x-3p	91.4101	NM_001282971
MTSS1	hsa-miR-548aj-3p	91.4101	NM_001282971
MTSS1	hsa-miR-586	91.3056	NM_001282971
MTSS1	hsa-miR-493-5p	90.7684	NM_001282971
MTSS1	hsa-miR-300	90.4683	NM_001282971
MTSS1	hsa-miR-381-3p	90.4683	NM_001282971
MTSS1	hsa-miR-4282	90.2864	NM_001282971
MTSS1	hsa-miR-548j-3p	89.7241	NM_001282971
MTSS1	hsa-miR-548ah-3p	89.7241	NM_001282971
MTSS1	hsa-miR-548am-3p	89.7241	NM_001282971
MTSS1	hsa-miR-548aq-3p	89.7241	NM_001282971
MTSS1	hsa-miR-548ae-3p	89.7241	NM_001282971
MTSS1	hsa-miR-6718-5p	89.6049	NM_001282971
MTSS1	hsa-miR-203b-5p	89.6049	NM_001282971
MTSS1	hsa-miR-3943	89.1051	NM_001282971
MTSS1	hsa-miR-127-5p	88.8456	NM_001282971
MTSS1	hsa-miR-196a-3p	88.5986	NM_001282971
MTSS1	hsa-miR-607	88.5732	NM_001282971
MTSS1	hsa-miR-4711-5p	88.5198	NM_001282971
MTSS1	hsa-miR-4694-3p	88.416	NM_001282971
MTSS1	hsa-miR-549a-5p	88.0681	NM_001282971
MTSS1	hsa-miR-892c-5p	88.003	NM_001282971
MTSS1	hsa-miR-6499-3p	87.3399	NM_001282971
MTSS1	hsa-miR-9851-3p	87.2969	NM_001282971
MTSS1	hsa-miR-8063	87.2861	NM_001282971
MTSS1	hsa-miR-6796-5p	86.6957	NM_001282971
MTSS1	hsa-miR-4263	86.3804	NM_001282971

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Motifs and transcription factors (TFs) regulating MTSS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MTSS1	hdpi__SSX3	SSX3 (directAnnotation).
MTSS1	metacluster_74.10	HNF1B (directAnnotation).
MTSS1	kznf__ZNF77_Imbeault2017_OM_MEME	ZNF77 (directAnnotation).
MTSS1	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
MTSS1	tfdimers__MD00342	IRF1; YY1 (directAnnotation).
MTSS1	transfac_pro__M06485	ZNF808 (directAnnotation).
MTSS1	transfac_pro__M01081	ZNF628 (directAnnotation).
MTSS1	transfac_pro__M06943	PBX3 (directAnnotation).
MTSS1	tfdimers__MD00349	GABPA; YY2 (directAnnotation).
MTSS1	transfac_pro__M05387	ZNF653 (inferredBy_Orthology).
MTSS1	transfac_pro__M06077	ZNF716 (directAnnotation).
MTSS1	tfdimers__MD00291	FOXO1; YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."