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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MDM4

Summary for MDM4

Gene information	Gene symbol	MDM4
	Ensembl ID	ENSG00000198625
	Entrez ID	4194
	Gene name	MDM4 regulator of p53
	Synonyms	HDMX\|MDMX
	Gene type	protein_coding
	UniProtAcc	O15151

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Dataset with differentially expressed gene: MDM4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.333164	4.00e-25
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.271319	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.25775	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.49324	3.03e-25
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.287913	3.60e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.416481	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	0.470375	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.410245	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.528258	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.391986	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.0474	7.36e-06
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.381122	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	B cells	0.273966	2.29e-03

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Expression of MDM4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MDM4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MDM4	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating MDM4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MDM4	hsa-miR-4795-3p	99.9982	NM_001204172
MDM4	hsa-miR-34a-5p	99.9886	NM_001278516
MDM4	hsa-miR-449a	99.9842	NM_001278516
MDM4	hsa-miR-126-5p	99.9805	NM_001204172
MDM4	hsa-miR-3613-3p	99.9681	NM_001204172
MDM4	hsa-miR-34c-5p	99.9678	NM_001278516
MDM4	hsa-miR-449b-5p	99.9678	NM_001278516
MDM4	hsa-miR-616-5p	99.8169	NM_001204172
MDM4	hsa-miR-373-5p	99.8169	NM_001204172
MDM4	hsa-miR-371b-5p	99.8169	NM_001204172
MDM4	hsa-miR-454-3p	99.5189	NM_001278516
MDM4	hsa-miR-130a-3p	99.4873	NM_001278516
MDM4	hsa-miR-3666	99.4217	NM_001278516
MDM4	hsa-miR-301a-3p	99.4217	NM_001278516
MDM4	hsa-miR-301b-3p	99.4217	NM_001278516
MDM4	hsa-miR-130b-3p	99.4217	NM_001278516
MDM4	hsa-miR-4295	99.4217	NM_001278516
MDM4	hsa-miR-150-5p	98.8159	NM_001278518
MDM4	hsa-miR-19b-3p	98.7057	NM_001278516
MDM4	hsa-miR-19a-3p	98.7057	NM_001278516
MDM4	hsa-miR-3682-5p	98.61	NM_001278516
MDM4	hsa-miR-548e-5p	98.4327	NM_001204172
MDM4	hsa-miR-651-3p	98.2263	NM_001204172
MDM4	hsa-miR-6720-5p	98.1152	NM_001278516
MDM4	hsa-miR-6512-3p	98.1152	NM_001278516
MDM4	hsa-miR-548au-3p	97.9911	NM_001278516
MDM4	hsa-miR-6849-3p	96.6866	NM_001278516
MDM4	hsa-miR-6835-3p	95.1994	NM_001204172
MDM4	hsa-miR-6805-3p	95.1989	NM_001278516
MDM4	hsa-miR-5691	95.1989	NM_001278516
MDM4	hsa-miR-4500	94.7904	NM_001278516
MDM4	hsa-miR-6830-5p	93.9169	NM_001278516
MDM4	hsa-miR-1273h-5p	93.87	NM_001204172
MDM4	hsa-miR-12136	93.256	NM_001278518
MDM4	hsa-miR-4478	93.1592	NM_001204172
MDM4	hsa-miR-6780a-5p	93.0135	NM_001204172
MDM4	hsa-miR-3156-3p	92.5906	NM_001278516
MDM4	hsa-miR-513a-3p	92.4801	NM_001278516
MDM4	hsa-miR-513c-3p	92.4801	NM_001278516
MDM4	hsa-miR-3942-3p	92.1005	NM_001204172
MDM4	hsa-miR-9983-3p	91.9273	NM_001204172
MDM4	hsa-let-7a-5p	91.8101	NM_001278516
MDM4	hsa-let-7g-5p	91.8101	NM_001278516
MDM4	hsa-let-7f-5p	91.8101	NM_001278516
MDM4	hsa-let-7c-5p	91.8101	NM_001278516
MDM4	hsa-let-7b-5p	91.8101	NM_001278516
MDM4	hsa-miR-98-5p	91.8101	NM_001278516
MDM4	hsa-let-7i-5p	91.8101	NM_001278516
MDM4	hsa-let-7e-5p	91.8101	NM_001278516
MDM4	hsa-miR-5690	91.4996	NM_001204172

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Motifs and transcription factors (TFs) regulating MDM4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MDM4	metacluster_141.4	GLIS2 (directAnnotation).
MDM4	metacluster_141.2	E2F2; E2F3 (directAnnotation).
MDM4	hdpi__TP73	TP73 (directAnnotation).
MDM4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MDM4	jaspar__MA1483.2	ELF2 (directAnnotation).
MDM4	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MDM4	metacluster_172.6	CHD2; E2F1 (directAnnotation).
MDM4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MDM4	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
MDM4	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
MDM4	hdpi__FLI1	FLI1 (directAnnotation).
MDM4	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
MDM4	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
MDM4	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
MDM4	cisbp__M02645	ETS1 (directAnnotation).
MDM4	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
MDM4	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
MDM4	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
MDM4	transfac_pro__M00492	STAT1 (directAnnotation).
MDM4	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
MDM4	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
MDM4	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
MDM4	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
MDM4	hdpi__ETV4	ETV4 (directAnnotation).
MDM4	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
MDM4	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
MDM4	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
MDM4	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
MDM4	metacluster_183.3	EHF; ELF3; FLI1; SPIB (directAnnotation). EHF; EHF; ELF2; ELF3; ELF4; ELF5; ERG; ERG; ETV3; ETV6; FLI1; SPI1; SPI1 (inferredBy_Orthology).
MDM4	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
MDM4	metacluster_183.4	ETS1 (inferredBy_Orthology).
MDM4	transfac_pro__M06173	ZNF85 (directAnnotation).
MDM4	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
MDM4	dbtfbs__TBX3_HepG2_ENCSR238QRG_merged_N2	TBX3 (directAnnotation).
MDM4	hocomoco__TBX3_MOUSE.H11MO.0.B	TBX3 (inferredBy_Orthology).
MDM4	metacluster_155.11	SPZ1 (directAnnotation).
MDM4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
MDM4	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
MDM4	transfac_pro__M07329	SP7 (directAnnotation).
MDM4	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
MDM4	transfac_pro__M01837	KLF11 (directAnnotation).
MDM4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MDM4	transfac_pro__M07310	SP5 (directAnnotation).
MDM4	metacluster_163.2	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."

1	Mir-1307 regulates cisplatin resistance by targeting Mdm4 in breast cancer expressing wild type P53