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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LDLRAD4

Summary for LDLRAD4

Gene information	Gene symbol	LDLRAD4
	Ensembl ID	ENSG00000168675
	Entrez ID	753
	Gene name	low density lipoprotein receptor class A domain containing 4
	Synonyms	C18orf1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LDLRAD4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.689596	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.315224	2.23e-11
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.277253	4.01e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	0.454966	4.52e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.354198	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.257943	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.332429	2.60e-19

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Expression of LDLRAD4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LDLRAD4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LDLRAD4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LDLRAD4	hsa-miR-5003-5p	98.798	NM_001003675
LDLRAD4	hsa-miR-374a-5p	96.9417	NM_001003675
LDLRAD4	hsa-miR-374b-5p	95.9737	NM_001003675
LDLRAD4	hsa-miR-1305	94.1258	NM_001276251
LDLRAD4	hsa-miR-134-3p	93.0815	NM_001276251
LDLRAD4	hsa-miR-4722-5p	92.6411	NM_001276251
LDLRAD4	hsa-miR-1827	91.8075	NM_001003675
LDLRAD4	hsa-miR-4310	91.6494	NM_001276251
LDLRAD4	hsa-miR-5692c	91.4344	NM_001003675
LDLRAD4	hsa-miR-5692b	91.4344	NM_001003675
LDLRAD4	hsa-miR-580-5p	91.0335	NM_001003675
LDLRAD4	hsa-miR-493-5p	90.995	NM_001276251
LDLRAD4	hsa-miR-6780b-3p	90.8256	NM_001003675
LDLRAD4	hsa-miR-3606-5p	90.8115	NM_001003675
LDLRAD4	hsa-miR-93-3p	90.4168	NM_001003675
LDLRAD4	hsa-miR-1277-5p	89.8181	NM_001276251
LDLRAD4	hsa-miR-891b	89.3783	NM_001003675
LDLRAD4	hsa-miR-454-3p	89.0645	NM_001003675
LDLRAD4	hsa-miR-301a-3p	88.8438	NM_001003675
LDLRAD4	hsa-miR-130b-3p	88.8438	NM_001003675
LDLRAD4	hsa-miR-301b-3p	88.8438	NM_001003675
LDLRAD4	hsa-miR-4295	88.8438	NM_001003675
LDLRAD4	hsa-miR-3666	88.8438	NM_001003675
LDLRAD4	hsa-miR-6868-3p	88.4442	NM_001003675
LDLRAD4	hsa-miR-130a-3p	88.1686	NM_001003675
LDLRAD4	hsa-miR-498-3p	87.904	NM_001003675
LDLRAD4	hsa-miR-1976	87.5606	NM_001003675
LDLRAD4	hsa-miR-7157-5p	87.3021	NM_001276251
LDLRAD4	hsa-miR-421	86.0287	NM_001003675
LDLRAD4	hsa-miR-767-5p	85.6919	NM_001003675
LDLRAD4	hsa-miR-623	85.2553	NM_001003675
LDLRAD4	hsa-miR-8068	85.1097	NM_001276251
LDLRAD4	hsa-miR-7844-5p	83.8349	NM_001276251
LDLRAD4	hsa-miR-1284	83.7583	NM_001003675
LDLRAD4	hsa-miR-144-3p	82.959	NM_001003675
LDLRAD4	hsa-miR-532-3p	82.9134	NM_001003675
LDLRAD4	hsa-miR-3662	82.791	NM_001276251
LDLRAD4	hsa-miR-4772-3p	82.7433	NM_001003675
LDLRAD4	hsa-miR-124-5p	81.8374	NM_001003675
LDLRAD4	hsa-miR-212-5p	81.4046	NM_001003675
LDLRAD4	hsa-miR-33a-5p	80.9702	NM_001003675
LDLRAD4	hsa-miR-33b-5p	80.9702	NM_001003675
LDLRAD4	hsa-miR-340-5p	80.689	NM_001003675
LDLRAD4	hsa-miR-298	80.6111	NM_001276251
LDLRAD4	hsa-miR-578	80.6105	NM_001276251
LDLRAD4	hsa-miR-5011-5p	80.575	NM_001276251
LDLRAD4	hsa-miR-6071	80.5117	NM_001003675
LDLRAD4	hsa-miR-383-3p	80.2543	NM_001003675
LDLRAD4	hsa-miR-7114-5p	80.2041	NM_001276251
LDLRAD4	hsa-miR-4677-5p	80.0213	NM_001003675

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Motifs and transcription factors (TFs) regulating LDLRAD4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LDLRAD4	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
LDLRAD4	transfac_public__M00446	SPZ1 (directAnnotation).
LDLRAD4	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
LDLRAD4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
LDLRAD4	transfac_pro__M01199	TRIM28 (directAnnotation).
LDLRAD4	transfac_pro__M03876	ZBTB33 (directAnnotation).
LDLRAD4	transfac_pro__M01837	KLF11 (directAnnotation).
LDLRAD4	transfac_pro__M01858	TFAP2B (directAnnotation).
LDLRAD4	transfac_pro__M07310	SP5 (directAnnotation).
LDLRAD4	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
LDLRAD4	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
LDLRAD4	transfac_pro__M07329	SP7 (directAnnotation).
LDLRAD4	transfac_pro__M03806	ZBTB7C (directAnnotation).
LDLRAD4	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
LDLRAD4	transfac_pro__M12694	ZFP14 (directAnnotation).
LDLRAD4	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
LDLRAD4	hdpi__VPS4B	VPS4B (directAnnotation).
LDLRAD4	cisbp__M00343	PAX6 (directAnnotation).
LDLRAD4	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LDLRAD4	transfac_pro__M01118	WT1 (directAnnotation).
LDLRAD4	hdpi__OTUD4	OTUD4 (directAnnotation).
LDLRAD4	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
LDLRAD4	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
LDLRAD4	transfac_public__M00039	CREB1 (directAnnotation).
LDLRAD4	transfac_public__M00040	ATF2 (directAnnotation).
LDLRAD4	transfac_pro__M08803	CREM (directAnnotation).
LDLRAD4	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
LDLRAD4	transfac_pro__M01864	ATF4 (directAnnotation).
LDLRAD4	transfac_pro__M07981	ATF3 (inferredBy_Orthology).
LDLRAD4	transfac_public__M00041	ATF2; JUN (directAnnotation).
LDLRAD4	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
LDLRAD4	transfac_pro__M07436	WT1 (directAnnotation).
LDLRAD4	transfac_pro__M04746	E2F1 (directAnnotation).
LDLRAD4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
LDLRAD4	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
LDLRAD4	metacluster_3.14	WT1; WT1 (directAnnotation).
LDLRAD4	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
LDLRAD4	cisbp__M07938	E2F1 (directAnnotation).
LDLRAD4	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
LDLRAD4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LDLRAD4	transfac_pro__M05402	BCL6B (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."