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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KTN1

Summary for KTN1

Gene information	Gene symbol	KTN1
	Ensembl ID	ENSG00000126777
	Entrez ID	3895
	Gene name	kinectin 1
	Synonyms	CG1\|KIAA0004\|KNT
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KTN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.276541	2.04e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.529152	7.17e-23
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.434529	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.323377	3.64e-21
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.935877	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.335552	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.35068	4.54e-25
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.296234	8.19e-16
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.373122	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.91242	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.451916	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.585535	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.30977	0.00e+00

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Expression of KTN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KTN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KTN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KTN1	hsa-miR-1468-3p	95.555	NM_001271014
KTN1	hsa-miR-9903	94.5297	NM_004986
KTN1	hsa-miR-182-5p	93.7554	NM_001271014
KTN1	hsa-miR-613	91.7923	NM_001271014
KTN1	hsa-miR-1-3p	91.7923	NM_001271014
KTN1	hsa-miR-206	91.7923	NM_001271014
KTN1	hsa-miR-6868-3p	91.0798	NM_004986
KTN1	hsa-miR-16-1-3p	89.6859	NM_004986
KTN1	hsa-miR-4766-3p	84.7642	NM_001271014
KTN1	hsa-miR-1248	83.0791	NM_004986
KTN1	hsa-miR-526b-5p	82.7616	NM_004986

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Motifs and transcription factors (TFs) regulating KTN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KTN1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
KTN1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
KTN1	flyfactorsurvey__Sug_F3-5-2_SOLEXA_5	GLIS2 (inferredBy_Orthology).
KTN1	metacluster_7.11	PRDM4 (directAnnotation).
KTN1	taipale_tf_pairs__GCM1_FOXI1_RTMAACATRNGGGN_CAP_repr	FOXI1; GCM1 (directAnnotation).
KTN1	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
KTN1	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
KTN1	metacluster_80.6	ZIC4 (directAnnotation).
KTN1	hdpi__EBF1	EBF1 (directAnnotation).
KTN1	metacluster_183.4	ETS1 (inferredBy_Orthology).
KTN1	transfac_pro__M02898	SMAD3 (directAnnotation).
KTN1	hdpi__HIP2	UBE2K (directAnnotation).
KTN1	hdpi__NRL	NRL (directAnnotation).
KTN1	transfac_pro__M00430	E2F1 (directAnnotation).
KTN1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
KTN1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
KTN1	transfac_pro__M07329	SP7 (directAnnotation).
KTN1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
KTN1	transfac_pro__M07397	ZNF148 (directAnnotation).
KTN1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
KTN1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
KTN1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
KTN1	transfac_pro__M07436	WT1 (directAnnotation).
KTN1	metacluster_3.14	WT1; WT1 (directAnnotation).
KTN1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
KTN1	transfac_pro__M01837	KLF11 (directAnnotation).
KTN1	transfac_pro__M07310	SP5 (directAnnotation).
KTN1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
KTN1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
KTN1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
KTN1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
KTN1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
KTN1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
KTN1	transfac_pro__M01175	ZBTB7B (directAnnotation).
KTN1	transfac_pro__M00716	ZBTB14 (directAnnotation).
KTN1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
KTN1	transfac_pro__M07297	MAZ (directAnnotation).
KTN1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
KTN1	metacluster_163.2	ZNF682 (directAnnotation).
KTN1	transfac_pro__M04916	TAF1 (directAnnotation).
KTN1	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
KTN1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
KTN1	transfac_pro__M00938	E2F1 (directAnnotation).
KTN1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KTN1	transfac_pro__M02090	E2F4 (directAnnotation).
KTN1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
KTN1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
KTN1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
KTN1	transfac_pro__M01303	SP1 (directAnnotation).
KTN1	metacluster_102.2	ZBED1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."