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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: KLF4

Summary for KLF4

Gene information	Gene symbol	KLF4
	Ensembl ID	ENSG00000136826
	Entrez ID	9314
	Gene name	KLF transcription factor 4
	Synonyms	EZF\|GKLF
	Gene type	protein_coding
	UniProtAcc	O43474

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Dataset with differentially expressed gene: KLF4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.34619	1.46e-03
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.467882	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.371504	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.358481	9.07e-09
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.632338	2.35e-19
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	0.540283	5.10e-07
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.678758	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.85198	7.18e-21
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.696926	6.25e-18
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.380617	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	-0.462498	1.30e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.97673	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.27985	2.04e-07

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Expression of KLF4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLF4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
KLF4	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating KLF4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLF4	hsa-miR-7-5p	98.6899	NM_001314052
KLF4	hsa-miR-656-3p	98.645	NM_001314052
KLF4	hsa-miR-92b-3p	98.6439	NM_001314052
KLF4	hsa-miR-32-5p	98.6439	NM_001314052
KLF4	hsa-miR-92a-3p	98.6439	NM_001314052
KLF4	hsa-miR-381-3p	98.4283	NM_001314052
KLF4	hsa-miR-300	98.4283	NM_001314052
KLF4	hsa-miR-25-3p	98.3656	NM_001314052
KLF4	hsa-miR-363-3p	98.3656	NM_001314052
KLF4	hsa-miR-367-3p	98.3656	NM_001314052
KLF4	hsa-miR-4302	98.1707	NM_001314052
KLF4	hsa-miR-6505-5p	97.457	NM_001314052
KLF4	hsa-miR-3119	96.059	NM_001314052
KLF4	hsa-miR-1229-3p	95.5452	NM_001314052
KLF4	hsa-miR-6504-3p	94.9749	NM_001314052
KLF4	hsa-miR-10399-5p	94.9749	NM_001314052
KLF4	hsa-miR-135b-5p	94.8471	NM_001314052
KLF4	hsa-miR-135a-5p	94.8471	NM_001314052
KLF4	hsa-miR-370-5p	94.0066	NM_001314052
KLF4	hsa-let-7b-3p	93.8392	NM_001314052
KLF4	hsa-let-7f-1-3p	93.8392	NM_001314052
KLF4	hsa-miR-98-3p	93.8392	NM_001314052
KLF4	hsa-let-7a-3p	93.8392	NM_001314052
KLF4	hsa-miR-591	93.0654	NM_001314052
KLF4	hsa-miR-4680-3p	92.6098	NM_001314052
KLF4	hsa-miR-1263	92.4817	NM_001314052
KLF4	hsa-miR-4666a-3p	92.3494	NM_001314052
KLF4	hsa-miR-5582-3p	92.1882	NM_001314052
KLF4	hsa-miR-5197-5p	92.0242	NM_001314052
KLF4	hsa-miR-4471	91.9714	NM_001314052
KLF4	hsa-miR-103a-3p	91.7984	NM_001314052
KLF4	hsa-miR-107	91.7984	NM_001314052
KLF4	hsa-let-7c-3p	91.7926	NM_001314052
KLF4	hsa-miR-524-5p	91.6578	NM_001314052
KLF4	hsa-miR-520d-5p	91.6578	NM_001314052
KLF4	hsa-miR-4288	91.1462	NM_001314052
KLF4	hsa-miR-4761-5p	90.8146	NM_001314052
KLF4	hsa-miR-26b-3p	90.7083	NM_001314052
KLF4	hsa-miR-450a-1-3p	90.3755	NM_001314052
KLF4	hsa-miR-632	89.9177	NM_001314052
KLF4	hsa-miR-5580-3p	88.6634	NM_001314052
KLF4	hsa-miR-508-3p	88.6173	NM_001314052
KLF4	hsa-miR-497-3p	88.4734	NM_001314052
KLF4	hsa-miR-8059	88.3168	NM_001314052
KLF4	hsa-miR-153-5p	88.071	NM_001314052
KLF4	hsa-miR-3140-5p	87.9896	NM_001314052
KLF4	hsa-miR-4311	87.6395	NM_001314052
KLF4	hsa-miR-346	87.632	NM_001314052
KLF4	hsa-miR-3910	87.5875	NM_001314052
KLF4	hsa-miR-449a	86.377	NM_001314052

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Motifs and transcription factors (TFs) regulating KLF4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLF4	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
KLF4	metacluster_143.13	ZBTB7A (directAnnotation).
KLF4	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
KLF4	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
KLF4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KLF4	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
KLF4	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
KLF4	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
KLF4	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
KLF4	transfac_pro__M07329	SP7 (directAnnotation).
KLF4	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
KLF4	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
KLF4	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
KLF4	hdpi__TP73	TP73 (directAnnotation).
KLF4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
KLF4	metacluster_167.7	IRF8 (inferredBy_Orthology).
KLF4	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
KLF4	transfac_pro__M05706	ZNF20 (directAnnotation).
KLF4	taipale_tf_pairs__GCM1_MAX_CACGTGNNNGCGGGY_CAP	GCM1; MAX (directAnnotation).
KLF4	taipale_tf_pairs__GCM1_MAX_NNCACGTGNNNGCGGGYN_CAP_repr	GCM1; MAX (directAnnotation).
KLF4	transfac_pro__M06573	ZNF419 (directAnnotation).
KLF4	hdpi__ZNF695	ZNF695 (directAnnotation).
KLF4	metacluster_103.2	ZNF136; ZNF680 (directAnnotation).
KLF4	metacluster_21.4	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
KLF4	transfac_pro__M06410	ZNF497 (directAnnotation).
KLF4	metacluster_134.1	ZFP69 (directAnnotation).
KLF4	hdpi__GTF3C2	GTF3C2 (directAnnotation).
KLF4	transfac_pro__M03806	ZBTB7C (directAnnotation).
KLF4	hdpi__NRL	NRL (directAnnotation).
KLF4	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
KLF4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
KLF4	transfac_pro__M05418	ZNF521 (directAnnotation).
KLF4	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
KLF4	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
KLF4	metacluster_22.29	NFE2 (directAnnotation).
KLF4	cisbp__M00341	PAX6 (directAnnotation).
KLF4	jaspar__MA1650.1	ZBTB14 (directAnnotation).
KLF4	taipale_tf_pairs__ERF_SREBF2_NNCACGTGACMGGAARNN_CAP_repr	ERF; SREBF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
KLF4	transfac_pro__M07461	up	Malignant cells	GSE138267	NA
KLF4	metacluster_195.2	up	Malignant cells	GSE140440	NA
KLF4	transfac_pro__M07461	up	Malignant cells	GSE140440	NA
KLF4	tfdimers__MD00391	down	Mono/Macro	GSE164551	NA
KLF4	metacluster_3.10	down	Mono/Macro	GSE164551	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."