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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: JARID2

Summary for JARID2

Gene information	Gene symbol	JARID2
	Ensembl ID	ENSG00000008083
	Entrez ID	3720
	Gene name	jumonji and AT-rich interaction domain containing 2
	Synonyms	JMJ
	Gene type	protein_coding
	UniProtAcc	Q92833

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Dataset with differentially expressed gene: JARID2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.653792	8.34e-43
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.409273	1.13e-39
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.298036	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.337677	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.332535	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.18761	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.275095	1.00e-36
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.254851	0.00e+00

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Expression of JARID2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to JARID2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating JARID2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JARID2	hsa-miR-3613-3p	99.9977	NM_001267040
JARID2	hsa-miR-6867-5p	99.9669	NM_001267040
JARID2	hsa-miR-155-5p	99.3516	NM_001267040
JARID2	hsa-miR-3065-3p	98.1367	NM_001267040
JARID2	hsa-miR-4795-3p	97.7242	NM_001267040
JARID2	hsa-miR-520d-5p	97.1465	NM_001267040
JARID2	hsa-miR-524-5p	97.1465	NM_001267040
JARID2	hsa-miR-708-3p	96.9396	NM_001267040
JARID2	hsa-miR-3145-5p	96.8779	NM_001267040
JARID2	hsa-miR-8060	96.0627	NM_001267040
JARID2	hsa-miR-454-3p	95.6934	NM_001267040
JARID2	hsa-miR-767-3p	94.6939	NM_001267040
JARID2	hsa-miR-130a-3p	94.2148	NM_001267040
JARID2	hsa-miR-130b-3p	94.2148	NM_001267040
JARID2	hsa-miR-3666	94.2148	NM_001267040
JARID2	hsa-miR-301a-3p	94.2148	NM_001267040
JARID2	hsa-miR-301b-3p	94.2148	NM_001267040
JARID2	hsa-miR-4295	94.2148	NM_001267040
JARID2	hsa-miR-383-3p	94.0219	NM_001267040
JARID2	hsa-miR-519d-5p	94.0196	NM_001267040
JARID2	hsa-let-7c-3p	94.0097	NM_001267040
JARID2	hsa-miR-4709-5p	93.7836	NM_004973
JARID2	hsa-miR-3167	93.6379	NM_001267040
JARID2	hsa-miR-876-5p	93.257	NM_001267040
JARID2	hsa-miR-126-5p	93.1796	NM_001267040
JARID2	hsa-miR-23a-3p	93.1093	NM_001267040
JARID2	hsa-miR-23c	93.1093	NM_001267040
JARID2	hsa-miR-23b-3p	93.1093	NM_001267040
JARID2	hsa-miR-508-5p	92.9926	NM_001267040
JARID2	hsa-miR-5088-3p	92.7579	NM_001267040
JARID2	hsa-miR-3922-5p	92.6821	NM_001267040
JARID2	hsa-miR-148b-3p	92.4866	NM_001267040
JARID2	hsa-miR-148a-3p	92.4866	NM_001267040
JARID2	hsa-miR-152-3p	92.4866	NM_001267040
JARID2	hsa-miR-7151-3p	92.2024	NM_004973
JARID2	hsa-miR-4446-5p	92.0441	NM_001267040
JARID2	hsa-miR-4692	92.0187	NM_001267040
JARID2	hsa-miR-4469	91.9927	NM_004973
JARID2	hsa-miR-6887-3p	91.9867	NM_001267040
JARID2	hsa-miR-6832-3p	91.8076	NM_001267040
JARID2	hsa-miR-497-3p	91.1696	NM_001267040
JARID2	hsa-miR-1297	91.084	NM_001267040
JARID2	hsa-miR-211-5p	91.083	NM_001267040
JARID2	hsa-miR-204-5p	91.083	NM_001267040
JARID2	hsa-miR-4418	90.7161	NM_001267040
JARID2	hsa-miR-509-3-5p	90.7161	NM_001267040
JARID2	hsa-miR-509-5p	90.7161	NM_001267040
JARID2	hsa-miR-136-5p	90.2943	NM_001267040
JARID2	hsa-miR-424-5p	90.0384	NM_001267040
JARID2	hsa-miR-497-5p	90.0384	NM_001267040

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Motifs and transcription factors (TFs) regulating JARID2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JARID2	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
JARID2	transfac_pro__M07387	ZBTB7A (directAnnotation).
JARID2	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
JARID2	metacluster_144.13	HIC1; HIC1 (directAnnotation).
JARID2	transfac_pro__M00514	ATF4 (directAnnotation).
JARID2	transfac_pro__M00665	SP3 (directAnnotation).
JARID2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
JARID2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
JARID2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
JARID2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
JARID2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
JARID2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
JARID2	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
JARID2	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
JARID2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
JARID2	transfac_pro__M07329	SP7 (directAnnotation).
JARID2	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
JARID2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
JARID2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
JARID2	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
JARID2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
JARID2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
JARID2	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
JARID2	transfac_pro__M01861	ATF1 (directAnnotation).
JARID2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
JARID2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
JARID2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
JARID2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
JARID2	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
JARID2	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
JARID2	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
JARID2	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
JARID2	jaspar__MA1951.1	FOS (directAnnotation).
JARID2	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
JARID2	transfac_pro__M04746	E2F1 (directAnnotation).
JARID2	transfac_public__M00039	CREB1 (directAnnotation).
JARID2	transfac_pro__M06141	ZNF708 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."