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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IRF2BP2

Summary for IRF2BP2

Gene information	Gene symbol	IRF2BP2
	Ensembl ID	ENSG00000168264
	Entrez ID	359948
	Gene name	interferon regulatory factor 2 binding protein 2
	Synonyms	IRF-2BP2
	Gene type	protein_coding
	UniProtAcc	Q7Z5L9

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Dataset with differentially expressed gene: IRF2BP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.566197	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.401466	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.272033	4.17e-20
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.341367	1.17e-11
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.472437	5.22e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.929459	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.295844	9.81e-45
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	Mono/Macro	-0.274846	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.415962	1.40e-45
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.830731	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	0.259317	3.33e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.268351	2.62e-43
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.634916	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.475416	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.834686	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.564054	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.366341	5.74e-09
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.461309	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.277055	1.16e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.272945	2.51e-10
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.431675	3.33e-20
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.867271	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.279635	0.00e+00

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Expression of IRF2BP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IRF2BP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IRF2BP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IRF2BP2	hsa-miR-5011-5p	99.9992	NM_001077397
IRF2BP2	hsa-miR-190a-3p	99.9921	NM_001077397
IRF2BP2	hsa-miR-3613-3p	99.6732	NM_001077397
IRF2BP2	hsa-miR-12136	97.7533	NM_001077397
IRF2BP2	hsa-miR-511-5p	97.6692	NM_182972
IRF2BP2	hsa-miR-4742-3p	96.963	NM_182972
IRF2BP2	hsa-miR-155-5p	96.9326	NM_001077397
IRF2BP2	hsa-miR-302e	96.4808	NM_001077397
IRF2BP2	hsa-miR-607	95.9314	NM_001077397
IRF2BP2	hsa-miR-4733-3p	95.8985	NM_001077397
IRF2BP2	hsa-miR-6835-3p	95.7818	NM_001077397
IRF2BP2	hsa-miR-302c-3p	95.6336	NM_001077397
IRF2BP2	hsa-miR-302d-3p	95.6336	NM_001077397
IRF2BP2	hsa-miR-302a-3p	95.6336	NM_001077397
IRF2BP2	hsa-miR-302b-3p	95.6336	NM_001077397
IRF2BP2	hsa-miR-548c-3p	95.3138	NM_001077397
IRF2BP2	hsa-miR-4717-5p	94.8219	NM_001077397
IRF2BP2	hsa-miR-10395-3p	94.5303	NM_182972
IRF2BP2	hsa-miR-4422	94.2674	NM_001077397
IRF2BP2	hsa-miR-4698	94.2631	NM_001077397
IRF2BP2	hsa-miR-8063	94.1386	NM_001077397
IRF2BP2	hsa-miR-520d-3p	94.0829	NM_001077397
IRF2BP2	hsa-miR-372-3p	94.0829	NM_001077397
IRF2BP2	hsa-miR-373-3p	94.0829	NM_001077397
IRF2BP2	hsa-miR-520b-3p	94.0829	NM_001077397
IRF2BP2	hsa-miR-520e-3p	94.0829	NM_001077397
IRF2BP2	hsa-miR-520a-3p	94.0829	NM_001077397
IRF2BP2	hsa-miR-520c-3p	94.0829	NM_001077397
IRF2BP2	hsa-miR-519b-3p	91.6449	NM_001077397
IRF2BP2	hsa-miR-519c-3p	91.6449	NM_001077397
IRF2BP2	hsa-miR-519a-3p	91.6449	NM_001077397
IRF2BP2	hsa-miR-6780b-3p	91.39	NM_182972
IRF2BP2	hsa-miR-6773-3p	90.7015	NM_001077397
IRF2BP2	hsa-miR-548n	90.6948	NM_001077397
IRF2BP2	hsa-miR-8055	90.5533	NM_182972
IRF2BP2	hsa-miR-548e-5p	90.2681	NM_182972
IRF2BP2	hsa-miR-548as-3p	90.231	NM_182972
IRF2BP2	hsa-miR-548p	89.6097	NM_001077397
IRF2BP2	hsa-miR-620	89.4721	NM_182972
IRF2BP2	hsa-miR-3119	89.1597	NM_001077397
IRF2BP2	hsa-miR-4753-5p	89.1573	NM_182972
IRF2BP2	hsa-miR-1324	88.8451	NM_001077397
IRF2BP2	hsa-miR-1261	88.4464	NM_001077397
IRF2BP2	hsa-miR-4328	88.3101	NM_001077397
IRF2BP2	hsa-miR-12135	88.0654	NM_182972
IRF2BP2	hsa-miR-1270	87.8014	NM_182972
IRF2BP2	hsa-miR-1468-3p	87.7825	NM_001077397
IRF2BP2	hsa-miR-548m	87.6988	NM_182972
IRF2BP2	hsa-miR-6730-5p	87.4306	NM_182972
IRF2BP2	hsa-miR-3692-3p	86.4654	NM_001077397

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Motifs and transcription factors (TFs) regulating IRF2BP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IRF2BP2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
IRF2BP2	transfac_pro__M04893	TAF1 (directAnnotation).
IRF2BP2	transfac_pro__M01199	TRIM28 (directAnnotation).
IRF2BP2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
IRF2BP2	hdpi__HIP2	UBE2K (directAnnotation).
IRF2BP2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
IRF2BP2	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
IRF2BP2	transfac_pro__M00938	E2F1 (directAnnotation).
IRF2BP2	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
IRF2BP2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
IRF2BP2	hdpi__RARA	RARA (directAnnotation).
IRF2BP2	jaspar__MA1583.1	ZFP57 (directAnnotation).
IRF2BP2	cisbp__M00968	MTF2 (directAnnotation).
IRF2BP2	transfac_pro__M02898	SMAD3 (directAnnotation).
IRF2BP2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
IRF2BP2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
IRF2BP2	jaspar__MA1721.1	ZNF93 (directAnnotation).
IRF2BP2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
IRF2BP2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
IRF2BP2	metacluster_151.2	ZNF23 (directAnnotation).
IRF2BP2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
IRF2BP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
IRF2BP2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
IRF2BP2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
IRF2BP2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
IRF2BP2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
IRF2BP2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
IRF2BP2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
IRF2BP2	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
IRF2BP2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
IRF2BP2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
IRF2BP2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
IRF2BP2	transfac_pro__M04817	ZBTB33 (directAnnotation).
IRF2BP2	metacluster_175.1	ZNF283 (directAnnotation).
IRF2BP2	tfdimers__MD00364	WT1 (directAnnotation).
IRF2BP2	hdpi__ZNF304	ZNF304 (directAnnotation).
IRF2BP2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
IRF2BP2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
IRF2BP2	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
IRF2BP2	transfac_pro__M01973	PLAG1 (directAnnotation).
IRF2BP2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
IRF2BP2	metacluster_198.3	ZFP64 (directAnnotation).
IRF2BP2	metacluster_143.13	ZBTB7A (directAnnotation).
IRF2BP2	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
IRF2BP2	transfac_pro__M07387	ZBTB7A (directAnnotation).
IRF2BP2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
IRF2BP2	metacluster_144.13	HIC1; HIC1 (directAnnotation).
IRF2BP2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
IRF2BP2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
IRF2BP2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."