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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HPRT1

Summary for HPRT1

Gene information	Gene symbol	HPRT1
	Ensembl ID	ENSG00000165704
	Entrez ID	3251
	Gene name	hypoxanthine phosphoribosyltransferase 1
	Synonyms	HGPRT\|HPRT
	Gene type	protein_coding
	UniProtAcc	P00492

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Dataset with differentially expressed gene: HPRT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.304738	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.45834	5.03e-34
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.443301	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.431929	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.336689	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.262317	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.562358	5.61e-45
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.626772	7.32e-35
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.654701	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.432889	2.45e-16
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.304412	0.00e+00

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Expression of HPRT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HPRT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HPRT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HPRT1	hsa-miR-454-3p	97.0046	NM_000194
HPRT1	hsa-miR-130b-3p	96.2413	NM_000194
HPRT1	hsa-miR-3666	96.2413	NM_000194
HPRT1	hsa-miR-130a-3p	96.2413	NM_000194
HPRT1	hsa-miR-301b-3p	96.2413	NM_000194
HPRT1	hsa-miR-4295	96.2413	NM_000194
HPRT1	hsa-miR-301a-3p	96.2413	NM_000194
HPRT1	hsa-miR-600	96.1533	NM_000194
HPRT1	hsa-miR-4671-3p	96.0216	NM_000194
HPRT1	hsa-miR-19b-3p	94.1671	NM_000194
HPRT1	hsa-miR-19a-3p	94.1671	NM_000194
HPRT1	hsa-miR-3074-5p	92.695	NM_000194
HPRT1	hsa-miR-4753-3p	91.7811	NM_000194
HPRT1	hsa-miR-576-5p	89.7866	NM_000194
HPRT1	hsa-miR-4263	89.7866	NM_000194
HPRT1	hsa-miR-3163	87.8511	NM_000194
HPRT1	hsa-miR-450a-1-3p	85.4489	NM_000194
HPRT1	hsa-miR-653-3p	84.9494	NM_000194
HPRT1	hsa-miR-942-5p	81.8287	NM_000194
HPRT1	hsa-miR-4799-5p	81.1593	NM_000194
HPRT1	hsa-miR-4705	80.3729	NM_000194
HPRT1	hsa-miR-512-3p	80.3384	NM_000194

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Motifs and transcription factors (TFs) regulating HPRT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HPRT1	transfac_pro__M04817	ZBTB33 (directAnnotation).
HPRT1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
HPRT1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
HPRT1	transfac_pro__M00716	ZBTB14 (directAnnotation).
HPRT1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
HPRT1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
HPRT1	metacluster_163.2	ZNF682 (directAnnotation).
HPRT1	transfac_pro__M04916	TAF1 (directAnnotation).
HPRT1	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
HPRT1	transfac_pro__M00938	E2F1 (directAnnotation).
HPRT1	transfac_pro__M02090	E2F4 (directAnnotation).
HPRT1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
HPRT1	swissregulon__hs__CHD1	CHD1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HPRT1	"3H-pyrazolo[4,3-d]pyrimidin-7-ol"	DB03153	small molecule
HPRT1	"5-monophosphate-9-beta-D-ribofuranosyl xanthine"	DB02309	small molecule
HPRT1	"5-O-phosphono-alpha-D-ribofuranosyl diphosphate"	DB01632	small molecule
HPRT1	"9-Deazaguanine"	DB04356	small molecule
HPRT1	"Mercaptopurine"	DB01033	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."