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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HNRNPD

Summary for HNRNPD

Gene information	Gene symbol	HNRNPD
	Ensembl ID	ENSG00000138668
	Entrez ID	3184
	Gene name	heterogeneous nuclear ribonucleoprotein D
	Synonyms	AUF1\|HNRPD
	Gene type	protein_coding
	UniProtAcc	Q14103

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Dataset with differentially expressed gene: HNRNPD

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.55018	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.270961	7.06e-09
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.420954	1.14e-17
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.559642	6.72e-26
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.478922	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.279058	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.260819	2.99e-33
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.269954	3.22e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.281548	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.536336	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.415495	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.388865	1.10e-04
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.623319	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.524675	2.52e-30
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.829649	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.564135	4.56e-37
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.326494	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.576663	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.37972	0.00e+00

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Expression of HNRNPD in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HNRNPD

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HNRNPD

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HNRNPD	hsa-miR-4482-3p	96.5283	NM_031369
HNRNPD	hsa-miR-495-5p	96.0613	NM_001003810
HNRNPD	hsa-miR-3658	94.3599	NM_031369
HNRNPD	hsa-miR-4684-3p	94.3458	NM_031369
HNRNPD	hsa-miR-382-5p	93.6681	NM_001003810
HNRNPD	hsa-let-7f-1-3p	92.9331	NM_001003810
HNRNPD	hsa-miR-98-3p	92.9331	NM_001003810
HNRNPD	hsa-let-7b-3p	92.9331	NM_001003810
HNRNPD	hsa-let-7a-3p	92.9331	NM_001003810
HNRNPD	hsa-miR-203b-3p	91.3232	NM_001003810
HNRNPD	hsa-miR-146b-5p	89.4512	NM_031369
HNRNPD	hsa-miR-146a-5p	89.4512	NM_031369
HNRNPD	hsa-miR-7153-5p	89.4512	NM_031369
HNRNPD	hsa-miR-12123	89.1993	NM_001003810
HNRNPD	hsa-miR-6857-5p	89.1703	NM_031369
HNRNPD	hsa-miR-6079	88.8022	NM_031369
HNRNPD	hsa-miR-10527-5p	88.0157	NM_001003810
HNRNPD	hsa-miR-4703-5p	86.8562	NM_001003810
HNRNPD	hsa-miR-6739-3p	85.0245	NM_031369
HNRNPD	hsa-miR-4766-3p	84.5341	NM_031369
HNRNPD	hsa-miR-507	84.4335	NM_031369
HNRNPD	hsa-miR-3942-5p	84.3808	NM_001003810
HNRNPD	hsa-miR-3908	84.3808	NM_001003810
HNRNPD	hsa-miR-6828-5p	83.7868	NM_031369
HNRNPD	hsa-miR-4477a	83.0824	NM_001003810
HNRNPD	hsa-miR-4452	82.7504	NM_031369
HNRNPD	hsa-miR-4719	82.3203	NM_001003810
HNRNPD	hsa-miR-200c-3p	80.714	NM_001003810
HNRNPD	hsa-miR-200b-3p	80.714	NM_001003810
HNRNPD	hsa-miR-429	80.714	NM_001003810
HNRNPD	hsa-miR-3147	80.5965	NM_031369
HNRNPD	hsa-miR-211-3p	80.3353	NM_031369

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Motifs and transcription factors (TFs) regulating HNRNPD

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HNRNPD	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
HNRNPD	transfac_pro__M01303	SP1 (directAnnotation).
HNRNPD	transfac_public__M00491	PATZ1 (directAnnotation).
HNRNPD	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
HNRNPD	transfac_pro__M07397	ZNF148 (directAnnotation).
HNRNPD	jaspar__MA1708.1	ETV7 (directAnnotation).
HNRNPD	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
HNRNPD	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
HNRNPD	jaspar__MA1932.1	HOXB13 (directAnnotation).
HNRNPD	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
HNRNPD	metacluster_81.7	CREB1 (directAnnotation).
HNRNPD	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
HNRNPD	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
HNRNPD	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
HNRNPD	transfac_pro__M01182	HINFP (directAnnotation).
HNRNPD	transfac_pro__M06660	ZNF670 (directAnnotation).
HNRNPD	transfac_pro__M06991	MAFF (directAnnotation).
HNRNPD	hocomoco__E2F8_HUMAN.H11MO.0.D	E2F8 (directAnnotation).
HNRNPD	homer__TACGTGCV_HIF-1a	HIF1A (directAnnotation).
HNRNPD	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
HNRNPD	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
HNRNPD	transfac_pro__M02090	E2F4 (directAnnotation).
HNRNPD	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
HNRNPD	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
HNRNPD	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
HNRNPD	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
HNRNPD	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
HNRNPD	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
HNRNPD	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
HNRNPD	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
HNRNPD	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
HNRNPD	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
HNRNPD	transfac_pro__M04817	ZBTB33 (directAnnotation).
HNRNPD	transfac_pro__M02089	E2F3 (directAnnotation).
HNRNPD	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
HNRNPD	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
HNRNPD	hdpi__NRL	NRL (directAnnotation).
HNRNPD	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
HNRNPD	transfac_pro__M07329	SP7 (directAnnotation).
HNRNPD	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
HNRNPD	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
HNRNPD	transfac_pro__M07436	WT1 (directAnnotation).
HNRNPD	transfac_pro__M01837	KLF11 (directAnnotation).
HNRNPD	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
HNRNPD	transfac_pro__M07310	SP5 (directAnnotation).
HNRNPD	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
HNRNPD	swissregulon__hs__KLF6	KLF6 (directAnnotation).
HNRNPD	transfac_pro__M00716	ZBTB14 (directAnnotation).
HNRNPD	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
HNRNPD	transfac_pro__M04916	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HNRNPD	"Artenimol"	DB11638	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."