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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HMGXB4

Summary for HMGXB4

Gene information	Gene symbol	HMGXB4
	Ensembl ID	ENSG00000100281
	Entrez ID	10042
	Gene name	HMG-box containing 4
	Synonyms	HMG2L1\|P53N\|THC211630
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HMGXB4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.329984	1.84e-19
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.326186	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.290214	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.570074	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.313345	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.383808	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.390858	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.276415	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.337909	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.298047	2.10e-23
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.310938	0.00e+00

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Expression of HMGXB4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HMGXB4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HMGXB4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HMGXB4	hsa-miR-190a-3p	99.9805	NM_001003681
HMGXB4	hsa-miR-5011-5p	99.9644	NM_001003681
HMGXB4	hsa-miR-3924	99.7028	NM_001003681
HMGXB4	hsa-miR-3059-5p	99.5658	NM_001003681
HMGXB4	hsa-let-7a-3p	99.5258	NM_001003681
HMGXB4	hsa-let-7f-1-3p	99.5258	NM_001003681
HMGXB4	hsa-miR-98-3p	99.5258	NM_001003681
HMGXB4	hsa-let-7b-3p	99.5258	NM_001003681
HMGXB4	hsa-miR-1185-2-3p	99.2744	NM_001003681
HMGXB4	hsa-miR-1185-1-3p	99.2744	NM_001003681
HMGXB4	hsa-miR-4789-5p	99.2106	NM_001003681
HMGXB4	hsa-let-7f-2-3p	99.1941	NM_001003681
HMGXB4	hsa-miR-6715a-3p	98.0322	NM_001003681
HMGXB4	hsa-miR-3163	97.1506	NM_001003681
HMGXB4	hsa-miR-3191-5p	95.7651	NM_001003681
HMGXB4	hsa-miR-634	95.5111	NM_001003681
HMGXB4	hsa-miR-3714	95.3192	NM_001003681
HMGXB4	hsa-miR-4476	95.1746	NM_001003681
HMGXB4	hsa-miR-4789-3p	93.715	NM_001003681
HMGXB4	hsa-miR-6780a-3p	93.2344	NM_001003681
HMGXB4	hsa-miR-7111-3p	93.2344	NM_001003681
HMGXB4	hsa-miR-6881-3p	92.6372	NM_001003681
HMGXB4	hsa-miR-548x-3p	91.9905	NM_001003681
HMGXB4	hsa-miR-548aj-3p	91.9905	NM_001003681
HMGXB4	hsa-miR-3177-5p	91.5257	NM_001003681
HMGXB4	hsa-miR-624-5p	91.0364	NM_001003681
HMGXB4	hsa-miR-4282	90.6823	NM_001003681
HMGXB4	hsa-miR-518c-5p	90.3476	NM_001003681
HMGXB4	hsa-miR-6876-5p	89.9606	NM_001003681
HMGXB4	hsa-miR-597-3p	89.753	NM_001003681
HMGXB4	hsa-miR-548aq-3p	88.8446	NM_001003681
HMGXB4	hsa-miR-548am-3p	88.8446	NM_001003681
HMGXB4	hsa-miR-548j-3p	88.8446	NM_001003681
HMGXB4	hsa-miR-548ah-3p	88.8446	NM_001003681
HMGXB4	hsa-miR-548ae-3p	88.8446	NM_001003681
HMGXB4	hsa-miR-9500	87.712	NM_001003681
HMGXB4	hsa-miR-10524-5p	87.5272	NM_001003681
HMGXB4	hsa-let-7c-3p	87.2106	NM_001003681
HMGXB4	hsa-miR-495-3p	86.9325	NM_001003681
HMGXB4	hsa-miR-5688	86.9325	NM_001003681
HMGXB4	hsa-miR-297	86.6428	NM_001003681
HMGXB4	hsa-miR-381-3p	86.3324	NM_001003681
HMGXB4	hsa-miR-300	86.3324	NM_001003681
HMGXB4	hsa-miR-670-3p	85.6056	NM_001003681
HMGXB4	hsa-miR-7856-5p	85.3054	NM_001003681
HMGXB4	hsa-miR-548e-5p	85.1331	NM_001003681
HMGXB4	hsa-miR-4666a-3p	84.9747	NM_001003681
HMGXB4	hsa-miR-4533	84.8751	NM_001003681
HMGXB4	hsa-miR-6511a-5p	84.1255	NM_001003681
HMGXB4	hsa-miR-1910-3p	84.1255	NM_001003681

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Motifs and transcription factors (TFs) regulating HMGXB4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HMGXB4	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
HMGXB4	metacluster_182.10	ZFX (directAnnotation).
HMGXB4	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
HMGXB4	transfac_public__M00024	E2F1 (directAnnotation).
HMGXB4	transfac_pro__M07483	CXXC1 (directAnnotation).
HMGXB4	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
HMGXB4	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
HMGXB4	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
HMGXB4	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
HMGXB4	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
HMGXB4	transfac_pro__M01253	CNOT3 (directAnnotation).
HMGXB4	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
HMGXB4	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
HMGXB4	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
HMGXB4	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
HMGXB4	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
HMGXB4	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
HMGXB4	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
HMGXB4	transfac_pro__M04817	ZBTB33 (directAnnotation).
HMGXB4	transfac_pro__M12697	ZNF142 (directAnnotation).
HMGXB4	tfdimers__MD00364	WT1 (directAnnotation).
HMGXB4	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
HMGXB4	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
HMGXB4	transfac_pro__M01973	PLAG1 (directAnnotation).
HMGXB4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
HMGXB4	tfdimers__MD00483	ZBTB14 (directAnnotation).
HMGXB4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
HMGXB4	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
HMGXB4	metacluster_143.13	ZBTB7A (directAnnotation).
HMGXB4	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
HMGXB4	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
HMGXB4	transfac_pro__M07387	ZBTB7A (directAnnotation).
HMGXB4	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
HMGXB4	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
HMGXB4	metacluster_144.13	HIC1; HIC1 (directAnnotation).
HMGXB4	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
HMGXB4	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
HMGXB4	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
HMGXB4	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
HMGXB4	transfac_pro__M07329	SP7 (directAnnotation).
HMGXB4	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
HMGXB4	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
HMGXB4	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
HMGXB4	hdpi__ELF2	ELF2 (directAnnotation).
HMGXB4	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
HMGXB4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
HMGXB4	hdpi__NRL	NRL (directAnnotation).
HMGXB4	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
HMGXB4	transfac_pro__M01837	KLF11 (directAnnotation).
HMGXB4	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."