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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GSPT1

Summary for GSPT1

Gene information	Gene symbol	GSPT1
	Ensembl ID	ENSG00000103342
	Entrez ID	2935
	Gene name	G1 to S phase transition 1
	Synonyms	eRF3a\|ETF3A\|GST1
	Gene type	protein_coding
	UniProtAcc	P15170

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Dataset with differentially expressed gene: GSPT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.549583	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.33257	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.2837	1.08e-14
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	0.475311	2.92e-21
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.516123	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.628982	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	CD4+ T cells	0.2839	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.290982	2.22e-09
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.259851	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.338793	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.264979	1.40e-44
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.444117	8.11e-40
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.533686	7.32e-37
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.595857	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.472043	2.46e-28
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.371741	0.00e+00

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Expression of GSPT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GSPT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GSPT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GSPT1	hsa-miR-607	99.7837	NM_001130006
GSPT1	hsa-miR-4668-5p	99.4239	NM_001130006
GSPT1	hsa-miR-6828-5p	99.3131	NM_001130006
GSPT1	hsa-miR-5693	98.1777	NM_001130006
GSPT1	hsa-miR-6721-5p	97.6722	NM_001130006
GSPT1	hsa-miR-670-3p	97.5425	NM_002094
GSPT1	hsa-miR-4729	97.0127	NM_001130006
GSPT1	hsa-miR-12126	97.0112	NM_001130006
GSPT1	hsa-miR-3671	96.9881	NM_002094
GSPT1	hsa-miR-3646	96.9425	NM_001130006
GSPT1	hsa-miR-6739-5p	96.8051	NM_001130006
GSPT1	hsa-miR-6733-5p	96.8051	NM_001130006
GSPT1	hsa-miR-1468-3p	96.5153	NM_001130006
GSPT1	hsa-miR-3153	95.9246	NM_001130006
GSPT1	hsa-miR-5006-3p	95.5085	NM_001130006
GSPT1	hsa-miR-561-5p	95.4522	NM_001130006
GSPT1	hsa-miR-27b-3p	94.8832	NM_002094
GSPT1	hsa-miR-27a-3p	94.8832	NM_002094
GSPT1	hsa-miR-9985	94.8832	NM_002094
GSPT1	hsa-miR-548x-3p	94.5862	NM_001130006
GSPT1	hsa-miR-548aj-3p	94.5862	NM_001130006
GSPT1	hsa-miR-4755-5p	94.1703	NM_001130006
GSPT1	hsa-miR-8066	93.7961	NM_002094
GSPT1	hsa-miR-7847-3p	93.2169	NM_002094
GSPT1	hsa-miR-1273h-3p	93.162	NM_002094
GSPT1	hsa-miR-520d-5p	93.136	NM_001130006
GSPT1	hsa-miR-524-5p	93.136	NM_001130006
GSPT1	hsa-miR-548aw	92.7599	NM_001130006
GSPT1	hsa-miR-548ah-3p	92.685	NM_001130006
GSPT1	hsa-miR-548aq-3p	92.685	NM_001130006
GSPT1	hsa-miR-548am-3p	92.685	NM_001130006
GSPT1	hsa-miR-548ae-3p	92.685	NM_001130006
GSPT1	hsa-miR-548j-3p	92.685	NM_001130006
GSPT1	hsa-miR-3691-3p	91.7037	NM_001130006
GSPT1	hsa-miR-6830-5p	91.4175	NM_001130006
GSPT1	hsa-miR-4275	91.3352	NM_002094
GSPT1	hsa-miR-4531	91.333	NM_001130006
GSPT1	hsa-miR-320b	90.9925	NM_001130006
GSPT1	hsa-miR-4429	90.9925	NM_001130006
GSPT1	hsa-miR-320a-3p	90.9925	NM_001130006
GSPT1	hsa-miR-320d	90.9925	NM_001130006
GSPT1	hsa-miR-320c	90.9925	NM_001130006
GSPT1	hsa-miR-5696	90.8656	NM_001130006
GSPT1	hsa-miR-9500	90.8416	NM_001130006
GSPT1	hsa-miR-182-5p	90.6497	NM_001130006
GSPT1	hsa-miR-3059-5p	90.4054	NM_002094
GSPT1	hsa-miR-4477a	90.2766	NM_001130006
GSPT1	hsa-miR-450b-5p	90.0569	NM_001130006
GSPT1	hsa-miR-6507-3p	89.5251	NM_001130006
GSPT1	hsa-miR-532-3p	89.2828	NM_002094

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Motifs and transcription factors (TFs) regulating GSPT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GSPT1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
GSPT1	hdpi__ELF2	ELF2 (directAnnotation).
GSPT1	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
GSPT1	cisbp__M00968	MTF2 (directAnnotation).
GSPT1	transfac_pro__M02898	SMAD3 (directAnnotation).
GSPT1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GSPT1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
GSPT1	jaspar__MA1721.1	ZNF93 (directAnnotation).
GSPT1	jaspar__MA1122.1	TFDP1 (directAnnotation).
GSPT1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
GSPT1	transfac_pro__M07310	SP5 (directAnnotation).
GSPT1	hdpi__FLI1	FLI1 (directAnnotation).
GSPT1	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
GSPT1	transfac_pro__M04748	GABPA (directAnnotation).
GSPT1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
GSPT1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
GSPT1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
GSPT1	metacluster_183.4	ETS1 (inferredBy_Orthology).
GSPT1	metacluster_81.7	CREB1 (directAnnotation).
GSPT1	transfac_pro__M00492	STAT1 (directAnnotation).
GSPT1	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
GSPT1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
GSPT1	transfac_pro__M05427	ZNF516 (directAnnotation).
GSPT1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
GSPT1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
GSPT1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
GSPT1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
GSPT1	cisbp__M04023	CREB1 (directAnnotation).
GSPT1	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_HT	HOXB13; ONECUT2 (directAnnotation).
GSPT1	transfac_pro__M06277	ZNF404 (directAnnotation).
GSPT1	transfac_pro__M06408	ZSCAN30 (directAnnotation).
GSPT1	transfac_pro__M06805	ZNF280D (inferredBy_Orthology).
GSPT1	metacluster_168.18	ZNF214; ZNF239; ZNF45; ZNF696 (directAnnotation).
GSPT1	transfac_pro__M06730	ZNF624 (directAnnotation).
GSPT1	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
GSPT1	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
GSPT1	transfac_public__M00039	CREB1 (directAnnotation).
GSPT1	transfac_public__M00040	ATF2 (directAnnotation).
GSPT1	transfac_pro__M08803	CREM (directAnnotation).
GSPT1	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
GSPT1	transfac_pro__M01864	ATF4 (directAnnotation).
GSPT1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
GSPT1	hdpi__NRL	NRL (directAnnotation).
GSPT1	transfac_pro__M04817	ZBTB33 (directAnnotation).
GSPT1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
GSPT1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
GSPT1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GSPT1	transfac_pro__M07329	SP7 (directAnnotation).
GSPT1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
GSPT1	transfac_pro__M00716	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GSPT1	"Guanosine-5'-Diphosphate"	DB04315	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."