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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GOLGA4

Summary for GOLGA4

Gene information	Gene symbol	GOLGA4
	Ensembl ID	ENSG00000144674
	Entrez ID	2803
	Gene name	golgin A4
	Synonyms	GCP2\|GOLG\|golgin-240\|p230
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GOLGA4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.470215	2.93e-43
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.274343	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.252437	2.17e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.258907	1.06e-09
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.347726	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.256382	1.01e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.428897	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.422471	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.285478	2.80e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.37957	6.52e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.397202	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.252443	9.64e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.289663	5.91e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.896337	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.680126	0.00e+00

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Expression of GOLGA4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GOLGA4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GOLGA4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GOLGA4	hsa-miR-6780a-3p	94.8282	NM_001172713
GOLGA4	hsa-miR-302a-5p	94.7912	NM_001172713
GOLGA4	hsa-miR-1306-5p	93.9428	NM_002078
GOLGA4	hsa-miR-3121-3p	92.0359	NM_002078
GOLGA4	hsa-miR-4735-5p	91.5604	NM_002078
GOLGA4	hsa-miR-374a-3p	91.425	NM_001172713
GOLGA4	hsa-miR-32-5p	91.3421	NM_002078
GOLGA4	hsa-miR-92b-3p	91.3421	NM_002078
GOLGA4	hsa-miR-92a-3p	91.3421	NM_002078
GOLGA4	hsa-miR-4778-3p	90.9596	NM_002078
GOLGA4	hsa-miR-548c-3p	90.3575	NM_002078
GOLGA4	hsa-miR-361-5p	90.3181	NM_001172713
GOLGA4	hsa-miR-4640-5p	89.7795	NM_002078
GOLGA4	hsa-miR-25-3p	89.7304	NM_002078
GOLGA4	hsa-miR-363-3p	89.7304	NM_002078
GOLGA4	hsa-miR-367-3p	89.7304	NM_002078
GOLGA4	hsa-miR-2115-3p	89.016	NM_001172713
GOLGA4	hsa-miR-30c-5p	88.4339	NM_001172713
GOLGA4	hsa-miR-30e-5p	88.4339	NM_001172713
GOLGA4	hsa-miR-30a-5p	88.4339	NM_001172713
GOLGA4	hsa-miR-30d-5p	88.4339	NM_001172713
GOLGA4	hsa-miR-30b-5p	88.4339	NM_001172713
GOLGA4	hsa-miR-3059-5p	86.1826	NM_001172713
GOLGA4	hsa-miR-6513-5p	86.0927	NM_001172713
GOLGA4	hsa-miR-4726-5p	85.8419	NM_002078
GOLGA4	hsa-miR-642a-3p	84.9945	NM_002078
GOLGA4	hsa-miR-642b-3p	84.9945	NM_002078
GOLGA4	hsa-miR-3140-5p	84.3889	NM_002078
GOLGA4	hsa-miR-3133	83.5152	NM_002078
GOLGA4	hsa-miR-6074	83.3128	NM_002078
GOLGA4	hsa-miR-4310	81.2795	NM_001172713
GOLGA4	hsa-miR-7157-5p	80.0752	NM_001172713

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Motifs and transcription factors (TFs) regulating GOLGA4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GOLGA4	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
GOLGA4	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
GOLGA4	hdpi__NRL	NRL (directAnnotation).
GOLGA4	transfac_pro__M07317	CTBP1 (directAnnotation).
GOLGA4	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
GOLGA4	cisbp__M08228	PAX5 (directAnnotation).
GOLGA4	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
GOLGA4	transfac_pro__M03846	SMAD5 (directAnnotation).
GOLGA4	hdpi__FEZF2	FEZF2 (directAnnotation).
GOLGA4	cisbp__M00343	PAX6 (directAnnotation).
GOLGA4	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
GOLGA4	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
GOLGA4	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
GOLGA4	transfac_pro__M04646	FOXN4 (directAnnotation).
GOLGA4	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
GOLGA4	transfac_pro__M04617	ZBTB7A (directAnnotation).
GOLGA4	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
GOLGA4	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
GOLGA4	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."