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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: FOXP1

Summary for FOXP1

Gene information	Gene symbol	FOXP1
	Ensembl ID	ENSG00000114861
	Entrez ID	27086
	Gene name	forkhead box P1
	Synonyms	12CC4\|hFKH1B\|HSPC215\|QRF1
	Gene type	protein_coding
	UniProtAcc	Q9H334

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Dataset with differentially expressed gene: FOXP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.376361	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.380205	7.57e-44
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.405503	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.275956	1.20e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.363171	6.34e-06
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.30422	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.351962	9.58e-24
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mast cells	-0.817886	3.15e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	B cells	-0.309989	1.92e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.424218	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.271593	4.10e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.2927	1.03e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.407626	4.26e-13
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.254054	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.388428	2.58e-16
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.357768	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.811732	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.478919	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.280662	0.00e+00

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Expression of FOXP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FOXP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FOXP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FOXP1	hsa-miR-3148	97.9767	NM_001244813
FOXP1	hsa-miR-3944-5p	97.6899	NM_001244813
FOXP1	hsa-miR-206	96.1822	NM_001244813
FOXP1	hsa-miR-1-3p	96.1822	NM_001244813
FOXP1	hsa-miR-548c-3p	95.8485	NM_001244813
FOXP1	hsa-miR-107	95.17	NM_001244813
FOXP1	hsa-miR-103a-3p	95.17	NM_001244813
FOXP1	hsa-miR-8485	95.063	NM_001244813
FOXP1	hsa-miR-613	95.0577	NM_001244813
FOXP1	hsa-miR-9-5p	94.9202	NM_001244813
FOXP1	hsa-miR-3529-3p	94.8451	NM_001244813
FOXP1	hsa-miR-449a	94.5167	NM_001244813
FOXP1	hsa-miR-34a-5p	94.5167	NM_001244813
FOXP1	hsa-miR-449b-5p	94.5167	NM_001244813
FOXP1	hsa-miR-34c-5p	94.5167	NM_001244813
FOXP1	hsa-miR-1184	94.3874	NM_001244813
FOXP1	hsa-miR-548p	94.3713	NM_001244813
FOXP1	hsa-miR-582-5p	94.2202	NM_001244813
FOXP1	hsa-miR-548e-5p	94.079	NM_001244813
FOXP1	hsa-miR-6124	94.0002	NM_001244813
FOXP1	hsa-miR-1236-5p	93.3001	NM_001244813
FOXP1	hsa-miR-7159-5p	93.2101	NM_032682
FOXP1	hsa-miR-1305	92.7352	NM_001244813
FOXP1	hsa-miR-218-1-3p	92.5624	NM_001244813
FOXP1	hsa-miR-4262	92.2157	NM_001244813
FOXP1	hsa-miR-3613-3p	91.7578	NM_001244813
FOXP1	hsa-miR-6513-5p	91.5966	NM_001244813
FOXP1	hsa-miR-10527-5p	91.5499	NM_001244813
FOXP1	hsa-miR-1252-5p	90.5044	NM_001244813
FOXP1	hsa-miR-12136	90.4904	NM_001244813
FOXP1	hsa-miR-6882-3p	90.1016	NM_001244813
FOXP1	hsa-miR-6828-5p	89.9294	NM_001244813
FOXP1	hsa-miR-181a-5p	89.5239	NM_001244813
FOXP1	hsa-miR-181c-5p	89.5239	NM_001244813
FOXP1	hsa-miR-181b-5p	89.5239	NM_001244813
FOXP1	hsa-miR-181d-5p	89.5239	NM_001244813
FOXP1	hsa-miR-7162-3p	89.287	NM_001244813
FOXP1	hsa-miR-1468-3p	88.4347	NM_001244813
FOXP1	hsa-miR-532-5p	88.1447	NM_001244813
FOXP1	hsa-miR-3065-5p	87.5858	NM_032682
FOXP1	hsa-miR-4765	87.1792	NM_001244813
FOXP1	hsa-miR-659-3p	86.5858	NM_001244813
FOXP1	hsa-miR-3688-3p	84.848	NM_032682
FOXP1	hsa-miR-302a-5p	84.8062	NM_032682
FOXP1	hsa-miR-223-3p	84.5619	NM_001244813
FOXP1	hsa-miR-4697-3p	84.5619	NM_001244813
FOXP1	hsa-miR-486-5p	84.2423	NM_001244813
FOXP1	hsa-miR-612	84.0891	NM_001244813
FOXP1	hsa-miR-5189-5p	84.0253	NM_001244813
FOXP1	hsa-miR-1285-3p	84.0253	NM_001244813

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Motifs and transcription factors (TFs) regulating FOXP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FOXP1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
FOXP1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
FOXP1	hdpi__RARA	RARA (directAnnotation).
FOXP1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
FOXP1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
FOXP1	jaspar__MA1583.1	ZFP57 (directAnnotation).
FOXP1	jaspar__MA1721.1	ZNF93 (directAnnotation).
FOXP1	transfac_pro__M04916	TAF1 (directAnnotation).
FOXP1	jaspar__MA1122.1	TFDP1 (directAnnotation).
FOXP1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
FOXP1	transfac_pro__M07310	SP5 (directAnnotation).
FOXP1	metacluster_141.4	GLIS2 (directAnnotation).
FOXP1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
FOXP1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
FOXP1	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
FOXP1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
FOXP1	metacluster_172.6	CHD2; E2F1 (directAnnotation).
FOXP1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
FOXP1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
FOXP1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
FOXP1	hdpi__FLI1	FLI1 (directAnnotation).
FOXP1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
FOXP1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
FOXP1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
FOXP1	cisbp__M02645	ETS1 (directAnnotation).
FOXP1	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
FOXP1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
FOXP1	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
FOXP1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
FOXP1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
FOXP1	transfac_pro__M00492	STAT1 (directAnnotation).
FOXP1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
FOXP1	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
FOXP1	transfac_pro__M04944	GABPA (directAnnotation).
FOXP1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
FOXP1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
FOXP1	hdpi__ETV4	ETV4 (directAnnotation).
FOXP1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
FOXP1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
FOXP1	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
FOXP1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
FOXP1	transfac_pro__M06249	ZNF616 (directAnnotation).
FOXP1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
FOXP1	metacluster_183.4	ETS1 (inferredBy_Orthology).
FOXP1	transfac_pro__M06173	ZNF85 (directAnnotation).
FOXP1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
FOXP1	transfac_pro__M01122	ZNF219 (directAnnotation).
FOXP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FOXP1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
FOXP1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
FOXP1	metacluster_134.4	down	B cells	GSE189460	pre
FOXP1	hocomoco__FOXP1_HUMAN.H11MO.0.A	down	Mast cells	GSE207422_Sin	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."