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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FNIP1

Summary for FNIP1

Gene information	Gene symbol	FNIP1
	Ensembl ID	ENSG00000217128
	Entrez ID	96459
	Gene name	folliculin interacting protein 1
	Synonyms	KIAA1961
	Gene type	protein_coding
	UniProtAcc	Q8TF40

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Dataset with differentially expressed gene: FNIP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.52677	4.40e-40
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.33693	1.39e-12
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.339252	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.314274	0.00e+00

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Expression of FNIP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FNIP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FNIP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FNIP1	hsa-miR-92b-3p	99.591	NM_001008738
FNIP1	hsa-miR-32-5p	99.591	NM_001008738
FNIP1	hsa-miR-92a-3p	99.591	NM_001008738
FNIP1	hsa-miR-3617-5p	99.5653	NM_001008738
FNIP1	hsa-miR-641	99.5653	NM_001008738
FNIP1	hsa-miR-363-3p	99.5621	NM_001008738
FNIP1	hsa-miR-25-3p	99.4913	NM_001008738
FNIP1	hsa-miR-367-3p	99.4798	NM_001008738
FNIP1	hsa-miR-4495	98.6319	NM_001008738
FNIP1	hsa-miR-12129	97.6686	NM_001008738
FNIP1	hsa-miR-1272	96.9934	NM_133372
FNIP1	hsa-miR-186-5p	96.821	NM_133372
FNIP1	hsa-miR-190a-3p	96.2565	NM_001008738
FNIP1	hsa-miR-4773	96.2478	NM_001008738
FNIP1	hsa-miR-5680	96.1962	NM_133372
FNIP1	hsa-miR-6799-5p	96.055	NM_133372
FNIP1	hsa-miR-4325	95.0163	NM_001008738
FNIP1	hsa-miR-374a-5p	94.0883	NM_133372
FNIP1	hsa-miR-539-5p	93.8076	NM_001008738
FNIP1	hsa-miR-374b-5p	93.6846	NM_133372
FNIP1	hsa-miR-300	93.6836	NM_001008738
FNIP1	hsa-miR-369-3p	93.3511	NM_133372
FNIP1	hsa-miR-6751-3p	93.2086	NM_133372
FNIP1	hsa-miR-1199-5p	93.2086	NM_133372
FNIP1	hsa-miR-7-2-3p	93.122	NM_001008738
FNIP1	hsa-miR-7-1-3p	93.122	NM_001008738
FNIP1	hsa-miR-4500	93.0442	NM_001008738
FNIP1	hsa-miR-580-3p	92.7522	NM_001008738
FNIP1	hsa-miR-4303	92.4404	NM_133372
FNIP1	hsa-miR-218-1-3p	92.373	NM_001008738
FNIP1	hsa-miR-381-3p	92.2853	NM_001008738
FNIP1	hsa-miR-6832-3p	91.7523	NM_001008738
FNIP1	hsa-let-7a-5p	91.0739	NM_001008738
FNIP1	hsa-let-7f-5p	91.0739	NM_001008738
FNIP1	hsa-miR-98-5p	91.0739	NM_001008738
FNIP1	hsa-let-7b-5p	91.0739	NM_001008738
FNIP1	hsa-let-7g-5p	91.0739	NM_001008738
FNIP1	hsa-let-7i-5p	91.0739	NM_001008738
FNIP1	hsa-let-7e-5p	91.0739	NM_001008738
FNIP1	hsa-let-7c-5p	91.0739	NM_001008738
FNIP1	hsa-miR-510-5p	90.7889	NM_001008738
FNIP1	hsa-miR-95-5p	90.429	NM_001008738
FNIP1	hsa-miR-6715a-3p	89.8288	NM_133372
FNIP1	hsa-miR-6719-3p	89.7279	NM_133372
FNIP1	hsa-miR-3133	89.6268	NM_133372
FNIP1	hsa-miR-590-3p	89.6182	NM_133372
FNIP1	hsa-miR-4458	89.5071	NM_001008738
FNIP1	hsa-let-7d-5p	89.5071	NM_001008738
FNIP1	hsa-miR-4310	89.4788	NM_133372
FNIP1	hsa-miR-323a-3p	89.3299	NM_001008738

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Motifs and transcription factors (TFs) regulating FNIP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FNIP1	metacluster_175.1	ZNF283 (directAnnotation).
FNIP1	cisbp__M00788	ZFY (inferredBy_Orthology).
FNIP1	tfdimers__MD00364	WT1 (directAnnotation).
FNIP1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
FNIP1	hdpi__ZNF304	ZNF304 (directAnnotation).
FNIP1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FNIP1	transfac_pro__M04916	TAF1 (directAnnotation).
FNIP1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
FNIP1	tfdimers__MD00483	ZBTB14 (directAnnotation).
FNIP1	metacluster_198.3	ZFP64 (directAnnotation).
FNIP1	transfac_pro__M01303	SP1 (directAnnotation).
FNIP1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
FNIP1	metacluster_143.13	ZBTB7A (directAnnotation).
FNIP1	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
FNIP1	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
FNIP1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
FNIP1	transfac_pro__M00514	ATF4 (directAnnotation).
FNIP1	transfac_pro__M00665	SP3 (directAnnotation).
FNIP1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FNIP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FNIP1	transfac_pro__M02898	SMAD3 (directAnnotation).
FNIP1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
FNIP1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
FNIP1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
FNIP1	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
FNIP1	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
FNIP1	transfac_pro__M07329	SP7 (directAnnotation).
FNIP1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
FNIP1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FNIP1	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
FNIP1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
FNIP1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
FNIP1	hdpi__HIP2	UBE2K (directAnnotation).
FNIP1	hdpi__NRL	NRL (directAnnotation).
FNIP1	transfac_pro__M00430	E2F1 (directAnnotation).
FNIP1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
FNIP1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
FNIP1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
FNIP1	transfac_pro__M07397	ZNF148 (directAnnotation).
FNIP1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
FNIP1	cisbp__M07938	E2F1 (directAnnotation).
FNIP1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
FNIP1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
FNIP1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
FNIP1	transfac_pro__M07436	WT1 (directAnnotation).
FNIP1	transfac_pro__M01837	KLF11 (directAnnotation).
FNIP1	hdpi__TP73	TP73 (directAnnotation).
FNIP1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FNIP1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
FNIP1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."