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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM204A

Summary for FAM204A

Gene information	Gene symbol	FAM204A
	Ensembl ID	ENSG00000165669
	Entrez ID	63877
	Gene name	family with sequence similarity 204 member A
	Synonyms	bA319I23.1\|C10orf84\|FLJ13188
	Gene type	protein_coding
	UniProtAcc	Q9H8W3

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Dataset with differentially expressed gene: FAM204A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.370348	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.251881	1.98e-25
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.255489	6.59e-13
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.384724	6.82e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.298696	9.74e-13
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.254974	9.71e-07

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Expression of FAM204A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM204A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM204A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM204A	hsa-miR-3613-3p	96.6037	NM_001134672
FAM204A	hsa-miR-4680-3p	95.7986	NM_001134672
FAM204A	hsa-miR-6719-3p	92.3005	NM_001134672
FAM204A	hsa-miR-224-5p	91.9548	NM_001134672
FAM204A	hsa-miR-3074-3p	89.2376	NM_001134672
FAM204A	hsa-miR-6828-3p	88.5769	NM_001134672
FAM204A	hsa-miR-374b-3p	87.0432	NM_001134672
FAM204A	hsa-miR-4797-3p	86.7274	NM_001134672
FAM204A	hsa-miR-425-5p	85.951	NM_001134672
FAM204A	hsa-miR-767-3p	84.8783	NM_001134672
FAM204A	hsa-miR-3646	84.5816	NM_001134672
FAM204A	hsa-let-7f-1-3p	81.8381	NM_001134672
FAM204A	hsa-let-7b-3p	81.8381	NM_001134672
FAM204A	hsa-miR-98-3p	81.8381	NM_001134672
FAM204A	hsa-let-7a-3p	81.8381	NM_001134672
FAM204A	hsa-miR-656-3p	81.1344	NM_001134672
FAM204A	hsa-miR-371b-5p	80.813	NM_001134672
FAM204A	hsa-miR-616-5p	80.813	NM_001134672
FAM204A	hsa-miR-373-5p	80.813	NM_001134672
FAM204A	hsa-miR-203a-3p	80.7881	NM_001134672

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Motifs and transcription factors (TFs) regulating FAM204A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM204A	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
FAM204A	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
FAM204A	jaspar__MA0502.2	NFYB (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."