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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EIF4G1

Summary for EIF4G1

Gene information	Gene symbol	EIF4G1
	Ensembl ID	ENSG00000114867
	Entrez ID	1981
	Gene name	eukaryotic translation initiation factor 4 gamma 1
	Synonyms	EIF4F\|EIF4G\|p220\|PARK18
	Gene type	protein_coding
	UniProtAcc	Q04637

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Dataset with differentially expressed gene: EIF4G1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.311863	3.31e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.255212	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.451765	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.280018	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.380253	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Progenitors	-0.33801	3.87e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.462523	4.03e-40

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Expression of EIF4G1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EIF4G1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
EIF4G1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating EIF4G1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EIF4G1	hsa-miR-4452	97.316	NM_001194946
EIF4G1	hsa-miR-183-3p	93.882	NM_001194946
EIF4G1	hsa-miR-5011-5p	92.9111	NM_001194946
EIF4G1	hsa-miR-362-3p	90.5203	NM_001194946
EIF4G1	hsa-miR-4691-3p	89.6191	NM_001291157
EIF4G1	hsa-miR-190a-3p	89.5817	NM_001194946
EIF4G1	hsa-miR-329-3p	88.8242	NM_001194946
EIF4G1	hsa-miR-4760-3p	87.9779	NM_001194946
EIF4G1	hsa-miR-6747-3p	84.522	NM_001194946
EIF4G1	hsa-miR-7151-3p	83.2525	NM_001291157
EIF4G1	hsa-miR-6516-3p	80.2952	NM_001291157

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Motifs and transcription factors (TFs) regulating EIF4G1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EIF4G1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
EIF4G1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
EIF4G1	metacluster_58.2	SOX10; SOX9; SOX9 (directAnnotation).
EIF4G1	transfac_pro__M06267	ZNF805 (directAnnotation).
EIF4G1	metacluster_164.2	HMBOX1 (directAnnotation).
EIF4G1	transfac_pro__M02089	E2F3 (directAnnotation).
EIF4G1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
EIF4G1	hdpi__HIP2	UBE2K (directAnnotation).
EIF4G1	transfac_pro__M07329	SP7 (directAnnotation).
EIF4G1	cisbp__M07938	E2F1 (directAnnotation).
EIF4G1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
EIF4G1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
EIF4G1	transfac_pro__M07436	WT1 (directAnnotation).
EIF4G1	transfac_pro__M01837	KLF11 (directAnnotation).
EIF4G1	transfac_pro__M07310	SP5 (directAnnotation).
EIF4G1	transfac_pro__M04817	ZBTB33 (directAnnotation).
EIF4G1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
EIF4G1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
EIF4G1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
EIF4G1	transfac_pro__M04916	TAF1 (directAnnotation).
EIF4G1	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."