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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CHMP2B

Summary for CHMP2B

Gene information	Gene symbol	CHMP2B
	Ensembl ID	ENSG00000083937
	Entrez ID	25978
	Gene name	charged multivesicular body protein 2B
	Synonyms	CHMP2.5\|DKFZP564O123\|VPS2B
	Gene type	protein_coding
	UniProtAcc	Q9UQN3

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Dataset with differentially expressed gene: CHMP2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.255779	6.32e-36
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.258367	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.475196	1.51e-35
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.424465	1.11e-17
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.436703	1.78e-22
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.341765	6.82e-10
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.06194	0.00e+00

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Expression of CHMP2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHMP2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHMP2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHMP2B	hsa-miR-153-5p	99.8665	NM_001244644
CHMP2B	hsa-miR-9983-3p	97.4602	NM_014043
CHMP2B	hsa-miR-129-5p	97.1701	NM_014043
CHMP2B	hsa-miR-6844	96.6979	NM_001244644
CHMP2B	hsa-miR-5692a	95.7978	NM_001244644
CHMP2B	hsa-miR-4490	95.2381	NM_001244644
CHMP2B	hsa-miR-3680-3p	95.1586	NM_014043
CHMP2B	hsa-miR-450b-5p	95.0628	NM_014043
CHMP2B	hsa-miR-7157-3p	94.5381	NM_014043
CHMP2B	hsa-miR-6737-3p	94.5381	NM_014043
CHMP2B	hsa-miR-548aj-5p	94.1962	NM_014043
CHMP2B	hsa-miR-548f-5p	94.1962	NM_014043
CHMP2B	hsa-miR-548g-5p	94.1962	NM_014043
CHMP2B	hsa-miR-548x-5p	94.1962	NM_014043
CHMP2B	hsa-miR-5008-3p	94.1228	NM_014043
CHMP2B	hsa-miR-10527-5p	92.8199	NM_014043
CHMP2B	hsa-miR-1276	92.2769	NM_014043
CHMP2B	hsa-miR-4328	90.8391	NM_014043
CHMP2B	hsa-miR-182-5p	89.7515	NM_014043
CHMP2B	hsa-miR-4760-3p	89.4705	NM_014043
CHMP2B	hsa-miR-1256	88.9982	NM_014043
CHMP2B	hsa-miR-9-5p	88.8707	NM_001244644
CHMP2B	hsa-miR-1250-3p	88.1031	NM_001244644
CHMP2B	hsa-miR-30c-5p	86.6574	NM_014043
CHMP2B	hsa-miR-30e-5p	86.6574	NM_014043
CHMP2B	hsa-miR-30a-5p	86.6574	NM_014043
CHMP2B	hsa-miR-30d-5p	86.6574	NM_014043
CHMP2B	hsa-miR-30b-5p	86.6574	NM_014043
CHMP2B	hsa-miR-5197-5p	86.5341	NM_014043
CHMP2B	hsa-miR-205-3p	85.9025	NM_001244644
CHMP2B	hsa-miR-5680	85.7025	NM_001244644
CHMP2B	hsa-miR-548p	85.3688	NM_014043
CHMP2B	hsa-miR-466	84.9069	NM_014043
CHMP2B	hsa-miR-4262	83.9572	NM_014043
CHMP2B	hsa-miR-4282	83.6746	NM_014043
CHMP2B	hsa-miR-4276	83.616	NM_014043
CHMP2B	hsa-miR-1468-3p	83.3953	NM_014043
CHMP2B	hsa-miR-3926	83.3564	NM_014043
CHMP2B	hsa-miR-507	83.142	NM_014043
CHMP2B	hsa-miR-548m	82.3233	NM_014043
CHMP2B	hsa-miR-4793-3p	81.1858	NM_014043
CHMP2B	hsa-miR-6776-3p	80.9088	NM_014043
CHMP2B	hsa-miR-181a-5p	80.7143	NM_014043
CHMP2B	hsa-miR-181b-5p	80.7143	NM_014043
CHMP2B	hsa-miR-181c-5p	80.7143	NM_014043
CHMP2B	hsa-miR-181d-5p	80.7143	NM_014043
CHMP2B	hsa-miR-1208	80.5636	NM_014043

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Motifs and transcription factors (TFs) regulating CHMP2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHMP2B	metacluster_81.7	CREB1 (directAnnotation).
CHMP2B	transfac_pro__M00492	STAT1 (directAnnotation).
CHMP2B	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
CHMP2B	transfac_pro__M04748	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."